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PRJNA195909:zebrafish embryo and larva development
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Results for pparaa+pparda+ppardb
Z-value: 1.45
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Transcription factors associated with pparaa+pparda+ppardb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ppardb | dr11_v1_chr8_+_23711842_23711842 | 0.83 | 5.4e-03 | Click! |
| pparda | dr11_v1_chr22_+_997838_997838 | -0.83 | 5.9e-03 | Click! |
| pparaa | dr11_v1_chr4_-_18635005_18635005 | -0.49 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_999421 Show fit | 8.43 |
ENSDART00000149528
|
fatty acid binding protein 1b, tandem duplicate 1 |
|
| chr10_-_44027391 Show fit | 5.52 |
ENSDART00000145404
|
crystallin, beta B1 |
|
| chr25_+_21829777 Show fit | 4.70 |
ENSDART00000027393
|
creatine kinase, mitochondrial 1 |
|
| chr13_-_37127970 Show fit | 3.77 |
ENSDART00000135510
|
spectrin repeat containing, nuclear envelope 2b |
|
| chr19_+_40861853 Show fit | 3.07 |
ENSDART00000126470
|
zgc:85777 |
|
| chr11_-_6974022 Show fit | 3.06 |
ENSDART00000172851
|
si:ch211-43f4.1 |
|
| chr13_+_28819768 Show fit | 2.89 |
ENSDART00000191401
ENSDART00000188895 ENSDART00000101653 |
|
|
| chr12_-_5120339 Show fit | 2.88 |
ENSDART00000168759
|
retinol binding protein 4, plasma |
|
| chr14_-_48103207 Show fit | 2.75 |
ENSDART00000056712
|
electron-transferring-flavoprotein dehydrogenase |
|
| chr12_-_5120175 Show fit | 2.75 |
ENSDART00000160729
|
retinol binding protein 4, plasma |
Network of associatons between targets according to the STRING database.
First level regulatory network of pparaa+pparda+ppardb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0033993 | response to lipid(GO:0033993) |
| 0.8 | 5.6 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) |
| 0.0 | 4.9 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.4 | 4.7 | GO:0006603 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.1 | 3.9 | GO:0006949 | syncytium formation by plasma membrane fusion(GO:0000768) syncytium formation(GO:0006949) |
| 1.2 | 3.6 | GO:0009750 | response to fructose(GO:0009750) |
| 0.3 | 2.9 | GO:0061615 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 2.7 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 0.0 | 2.7 | GO:0048048 | embryonic eye morphogenesis(GO:0048048) |
| 0.0 | 2.7 | GO:0006936 | muscle contraction(GO:0006936) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 2.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.7 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 2.7 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 2.7 | GO:0044420 | extracellular matrix component(GO:0044420) |
| 0.2 | 2.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.6 | 1.9 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.1 | 1.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.2 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.8 | 5.6 | GO:0034632 | retinol transporter activity(GO:0034632) |
| 0.1 | 5.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 4.7 | GO:0016775 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.1 | 3.6 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.3 | 2.9 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.9 | 2.7 | GO:0016649 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.2 | 2.6 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.5 | 2.5 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) |
| 0.1 | 2.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 3.6 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.1 | 2.6 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 2.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 2.1 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.0 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |