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PRJNA195909:zebrafish embryo and larva development

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Results for pou6f1

Z-value: 0.86

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Transcription factors associated with pou6f1

Gene Symbol Gene ID Gene Info
pou6f1
ENSDARG00000011570 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou6f1dr11_v1_chr23_-_33702900_33702900-0.694.0e-02Click!

Activity profile of pou6f1 motif

Sorted Z-values of pou6f1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_44715224 2.61 ENSDART00000184630
si:dkey-56m19.5
si:dkey-56m19.5
chr9_-_22339582 2.29 ENSDART00000134805
crygm2d1
crystallin, gamma M2d1
chr4_+_12615836 2.05 ENSDART00000003583
lmo3
LIM domain only 3
chr11_+_41981959 1.87 ENSDART00000055707
her15.1
hairy and enhancer of split-related 15, tandem duplicate 1
chr9_-_14504834 1.84 ENSDART00000056103
nrp2b
neuropilin 2b
chr16_-_24044664 1.73 ENSDART00000136982
bcam
basal cell adhesion molecule (Lutheran blood group)
chr15_+_46356879 1.65 ENSDART00000154388
wu:fb18f06
wu:fb18f06
chr14_+_50770537 1.58 ENSDART00000158723
sncb
synuclein, beta
chr20_-_26491567 1.50 ENSDART00000147154
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr2_-_21349425 1.49 ENSDART00000171699
hhatla
hedgehog acyltransferase like, a
chr22_+_16535575 1.33 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr22_-_13350240 1.21 ENSDART00000154095
ENSDART00000155118
si:ch211-227m13.1
si:ch211-227m13.1
chr24_-_32408404 1.13 ENSDART00000144157
si:ch211-56a11.2
si:ch211-56a11.2
chr12_+_20352400 1.13 ENSDART00000066383
hbae5
hemoglobin, alpha embryonic 5
chr13_+_502230 1.12 ENSDART00000013007
degs1
delta(4)-desaturase, sphingolipid 1
chr12_+_27141140 1.11 ENSDART00000136415
hoxb1b
homeobox B1b
chr11_-_45138857 1.11 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr19_+_10847118 1.08 ENSDART00000189784
apoa4a
apolipoprotein A-IV a
chr19_+_30662529 1.06 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr15_-_17870090 1.02 ENSDART00000155066
atf5b
activating transcription factor 5b
chr16_-_2414063 1.00 ENSDART00000073621
zgc:152945
zgc:152945
chr17_+_12698532 0.96 ENSDART00000064509
ENSDART00000136830
stmn4l
stathmin-like 4, like
chr2_-_44255537 0.95 ENSDART00000011188
ENSDART00000093298
atp1a2a
ATPase Na+/K+ transporting subunit alpha 2
chr13_+_18533005 0.95 ENSDART00000136024
ftr14l
finTRIM family, member 14-like
chr3_-_28250722 0.91 ENSDART00000165936
rbfox1
RNA binding fox-1 homolog 1
chr25_+_37480285 0.89 ENSDART00000166187
CABZ01095001.1

chr6_+_60055168 0.89 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr5_+_64732270 0.88 ENSDART00000134241
olfm1a
olfactomedin 1a
chr8_+_37168570 0.79 ENSDART00000098636
csf1b
colony stimulating factor 1b (macrophage)
chr25_-_28600433 0.79 ENSDART00000138980
agbl2
ATP/GTP binding protein-like 2
chr19_-_31402429 0.75 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr2_-_50372467 0.73 ENSDART00000108900
cntnap2b
contactin associated protein like 2b
chr13_-_21701323 0.70 ENSDART00000164112
si:dkey-191g9.7
si:dkey-191g9.7
chr12_+_18681477 0.69 ENSDART00000127981
ENSDART00000143979
rgs9b
regulator of G protein signaling 9b
chr23_+_41912151 0.68 ENSDART00000191115
podn
podocan
chr24_+_22485710 0.67 ENSDART00000146058
si:dkey-40h20.1
si:dkey-40h20.1
chr18_-_1185772 0.67 ENSDART00000143245
nptnb
neuroplastin b
chr22_+_34710473 0.65 ENSDART00000155906
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr9_-_38036984 0.65 ENSDART00000134574
hacd2
3-hydroxyacyl-CoA dehydratase 2
chr9_-_21904695 0.65 ENSDART00000134768
lmo7a
LIM domain 7a
chr7_-_22941472 0.64 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr22_+_25672155 0.63 ENSDART00000087769
si:ch211-250e5.2
si:ch211-250e5.2
chr8_+_14158021 0.62 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr1_+_50968908 0.62 ENSDART00000150353
ENSDART00000012842
mdh1aa
malate dehydrogenase 1Aa, NAD (soluble)
chr9_+_41612642 0.62 ENSDART00000138473
spegb
SPEG complex locus b
chr14_+_3287740 0.62 ENSDART00000186290
cdx1a
caudal type homeobox 1a
chr2_+_9552456 0.60 ENSDART00000056896
dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_+_33341640 0.59 ENSDART00000186352
pyya
peptide YYa
chr7_-_9803154 0.59 ENSDART00000055593
aldh1a3
aldehyde dehydrogenase 1 family, member A3
chr13_+_43400443 0.58 ENSDART00000084321
dact2
dishevelled-binding antagonist of beta-catenin 2
chr3_+_57038033 0.58 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr4_+_12612723 0.57 ENSDART00000133767
lmo3
LIM domain only 3
chr25_+_6186823 0.56 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr22_+_34710036 0.56 ENSDART00000025820
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr1_+_45121393 0.56 ENSDART00000142702
muc13a
mucin 13a, cell surface associated
chr16_-_5154024 0.55 ENSDART00000132069
ENSDART00000060635
dctn3
dynactin 3 (p22)
chr15_-_33640890 0.50 ENSDART00000167705
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr4_+_22365061 0.48 ENSDART00000039277
lhfpl3
LHFPL tetraspan subfamily member 3
chr10_+_2715548 0.48 ENSDART00000130793
grk5
G protein-coupled receptor kinase 5
chr25_+_31958911 0.48 ENSDART00000191394
ENSDART00000090727
ENSDART00000185893
duox
dual oxidase
chr1_+_25801648 0.48 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr13_+_22119798 0.47 ENSDART00000173206
ENSDART00000078652
ENSDART00000165842
camk2g2
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2
chr3_-_21288202 0.46 ENSDART00000191766
ENSDART00000187319
fam171a2a
family with sequence similarity 171, member A2a
chr16_+_26017360 0.46 ENSDART00000149466
prss59.2
protease, serine, 59, tandem duplicate 2
chr19_+_42469058 0.45 ENSDART00000076915
si:dkey-166k12.1
si:dkey-166k12.1
chr10_-_27199135 0.43 ENSDART00000189511
ENSDART00000180314
auts2a
autism susceptibility candidate 2a
chr6_+_3004972 0.42 ENSDART00000186750
ENSDART00000183862
ENSDART00000191485
ENSDART00000171014
ptprfa
protein tyrosine phosphatase, receptor type, f, a
chr4_+_14826299 0.42 ENSDART00000067035
shisal1a
shisa like 1a
chr9_-_32672129 0.42 ENSDART00000140581
gzm3.4
granzyme 3, tandem duplicate 4
chr21_+_25231160 0.38 ENSDART00000063089
ENSDART00000139127
gng8
guanine nucleotide binding protein (G protein), gamma 8
chr21_-_26918901 0.37 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr18_-_40773413 0.36 ENSDART00000133797
vaspb
vasodilator stimulated phosphoprotein b
chr13_-_42560662 0.35 ENSDART00000124898
CR792417.1

chr18_-_50524017 0.34 ENSDART00000150013
ENSDART00000149912
cd276
CD276 molecule
chr2_-_12243213 0.33 ENSDART00000113081
gpr158b
G protein-coupled receptor 158b
chr24_+_41931585 0.32 ENSDART00000130310
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr8_-_7474997 0.32 ENSDART00000146555
gata1b
GATA binding protein 1b
chr16_-_11798994 0.31 ENSDART00000135408
cnfn
cornifelin
chr1_-_59139848 0.30 ENSDART00000191863
si:ch1073-110a20.2
si:ch1073-110a20.2
chr19_+_46222428 0.29 ENSDART00000183984
vps28
vacuolar protein sorting 28 (yeast)
chr22_+_11520249 0.28 ENSDART00000063147
sgsh
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr4_-_76370630 0.27 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
si:ch73-158p21.3
chr23_+_45860676 0.27 ENSDART00000012234
syap1
synapse associated protein 1
chr9_-_6624663 0.27 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr18_-_50523399 0.27 ENSDART00000033591
cd276
CD276 molecule
chr19_+_46222918 0.26 ENSDART00000158703
vps28
vacuolar protein sorting 28 (yeast)
chr16_+_26012569 0.26 ENSDART00000148846
prss59.1
protease, serine, 59, tandem duplicate 1
chr24_-_21404367 0.26 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr20_+_15982482 0.25 ENSDART00000020999
angptl1a
angiopoietin-like 1a
chr11_-_26180714 0.25 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr4_-_19028861 0.24 ENSDART00000166374
si:dkey-31f5.11
si:dkey-31f5.11
chr22_+_2830703 0.24 ENSDART00000145463
ENSDART00000144785
si:dkey-20i20.8
si:dkey-20i20.8
chr20_-_51697437 0.23 ENSDART00000145391
si:ch211-14a11.2
si:ch211-14a11.2
chr4_-_76270779 0.23 ENSDART00000183709
ENSDART00000192689
si:ch211-106j21.4
si:ch211-106j21.4
chr21_-_20733615 0.22 ENSDART00000145544
si:ch211-22d5.2
si:ch211-22d5.2
chr4_+_47751483 0.21 ENSDART00000160043
si:ch211-196f19.1
si:ch211-196f19.1
chr6_-_29105727 0.21 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr21_-_30467900 0.20 ENSDART00000078949
ENSDART00000078953
afap1l1b
actin filament associated protein 1-like 1b
chr6_-_54107269 0.20 ENSDART00000190017
hyal2a
hyaluronoglucosaminidase 2a
chr2_+_6243144 0.19 ENSDART00000058258
gng5
guanine nucleotide binding protein (G protein), gamma 5
chr6_+_23712911 0.19 ENSDART00000167795
zgc:158654
zgc:158654
chr4_-_18202291 0.15 ENSDART00000169704
anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr13_+_25434932 0.15 ENSDART00000128562
si:dkey-51a16.9
si:dkey-51a16.9
chr4_-_72609735 0.14 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
si:cabz01054394.6
chr19_-_8600383 0.14 ENSDART00000081546
trim46b
tripartite motif containing 46b
chr11_-_7320211 0.14 ENSDART00000091664
apc2
adenomatosis polyposis coli 2
chr12_-_28983584 0.13 ENSDART00000112374
zgc:171713
zgc:171713
chr10_-_45058886 0.13 ENSDART00000159347
mrps24
mitochondrial ribosomal protein S24
chr2_-_57991041 0.11 ENSDART00000111512
si:dkeyp-68b7.12
si:dkeyp-68b7.12
chr16_-_21038015 0.10 ENSDART00000059239
snx10b
sorting nexin 10b
chr13_+_406635 0.08 ENSDART00000181275
CU570800.4

chr1_-_57280585 0.08 ENSDART00000152220
si:dkey-27j5.5
si:dkey-27j5.5
chr3_+_40796110 0.07 ENSDART00000014729
arpc1a
actin related protein 2/3 complex, subunit 1A
chr11_+_33628104 0.06 ENSDART00000165318
thsd7bb
thrombospondin, type I, domain containing 7Bb
chr13_-_46200240 0.06 ENSDART00000056984
ftr69
finTRIM family, member 69
chr22_-_10019768 0.06 ENSDART00000162077
BX324216.2

chr19_-_23799729 0.06 ENSDART00000151913
pimr88
Pim proto-oncogene, serine/threonine kinase, related 88
chr21_-_22547496 0.05 ENSDART00000166835
ENSDART00000089030
myo5b
myosin VB
chr5_-_35953472 0.04 ENSDART00000143448
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr9_-_44953664 0.03 ENSDART00000188558
ENSDART00000185210
vil1
villin 1
chr1_-_34335752 0.02 ENSDART00000140157
si:dkey-24h22.5
si:dkey-24h22.5
chr25_+_11002640 0.01 ENSDART00000156646
ENSDART00000073383
mhc1lga
major histocompatibility complex class I LGA
chr21_-_7953792 0.00 ENSDART00000124486
si:dkey-163m14.10
si:dkey-163m14.10

Network of associatons between targets according to the STRING database.

First level regulatory network of pou6f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0060254 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.4 1.3 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.3 1.0 GO:0065001 specification of axis polarity(GO:0065001)
0.2 0.9 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.2 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.2 1.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.2 1.8 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.2 1.1 GO:0021570 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.1 0.7 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.5 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 1.5 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.9 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 0.6 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.6 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 1.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.6 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 1.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.8 GO:0032418 lysosome localization(GO:0032418)
0.0 0.3 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.4 GO:0021884 forebrain neuron development(GO:0021884)
0.0 1.1 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.7 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.6 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.6 GO:0006595 polyamine metabolic process(GO:0006595)
0.0 1.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.9 GO:0021761 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.0 0.6 GO:0007631 feeding behavior(GO:0007631)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 2.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0014020 neural tube closure(GO:0001843) primary neural tube formation(GO:0014020)
0.0 1.9 GO:0001756 somitogenesis(GO:0001756)
0.0 0.1 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.1 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1903136 cuprous ion binding(GO:1903136)
0.2 1.5 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.7 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.2 1.8 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.6 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.1 1.0 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 1.1 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 1.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.9 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0051087 chaperone binding(GO:0051087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes