ISMARA results: pou3f2a+pou3f2b+pou3f3a+pou3f3b

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PRJNA195909:zebrafish embryo and larva development

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Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.97

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Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Gene Symbol	Gene ID	Gene Info
pou3f3a NCBI UniProt	ENSDARG00000042032	POU class 3 homeobox 3a
pou3f2a NCBI UniProt	ENSDARG00000070220	POU class 3 homeobox 2a
pou3f2b NCBI UniProt	ENSDARG00000076262	POU class 3 homeobox 2b
pou3f3b NCBI UniProt	ENSDARG00000095896	POU class 3 homeobox 3b
pou3f2b NCBI UniProt	ENSDARG00000112713	POU class 3 homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pou3f2a	dr11_v1_chr4_+_5741733_5741733	-0.86	3.0e-03	Click!
pou3f3b	dr11_v1_chr6_+_14949950_14949950	-0.84	5.0e-03	Click!
pou3f2b	dr11_v1_chr16_+_32559821_32559821	-0.59	9.5e-02	Click!
pou3f3a	dr11_v1_chr9_-_6661657_6661666	-0.02	9.5e-01	Click!

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_38258053 Show fit	6.27	ENSDART00000132516	elavl2 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 2
chr17_-_4245902 Show fit	5.54	ENSDART00000151851	gdf3 NCBI UniProt Show fit	growth differentiation factor 3
chr15_+_37936458 Show fit	2.18	ENSDART00000154491	si:ch73-380l3.2 NCBI UniProt Show fit	si:ch73-380l3.2
chr2_-_38284648 Show fit	2.13	ENSDART00000148281 ENSDART00000132621	si:ch211-14a17.7 NCBI UniProt Show fit	si:ch211-14a17.7
chr11_+_30253968 Show fit	2.12	ENSDART00000157272 ENSDART00000003475	ppef1 NCBI UniProt Show fit	protein phosphatase, EF-hand calcium binding domain 1
chr6_+_28208973 Show fit	2.12	ENSDART00000171216 ENSDART00000171377 ENSDART00000167389 ENSDART00000166988	LSM2 (1 of many) NCBI UniProt Show fit	si:ch73-14h10.2
chr24_+_34069675 Show fit	2.04	ENSDART00000143995	si:ch211-190p8.2 NCBI UniProt Show fit	si:ch211-190p8.2
chr2_-_1486023 Show fit	2.03	ENSDART00000113774	si:ch211-188c16.1 NCBI UniProt Show fit	si:ch211-188c16.1
chr11_+_35171406 Show fit	2.03	ENSDART00000110839	mon1a NCBI UniProt Show fit	MON1 secretory trafficking family member A
chr16_-_46578523 Show fit	1.99	ENSDART00000131061	si:dkey-152b24.6 NCBI UniProt Show fit	si:dkey-152b24.6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	5.5	GO:0038107	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0	4.1	GO:0006325	chromatin organization(GO:0006325)
0.1	3.3	GO:0006623	protein targeting to vacuole(GO:0006623)
0.5	3.0	GO:0002143	tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1	2.7	GO:0001522	pseudouridine synthesis(GO:0001522)
0.1	2.6	GO:0051639	actin filament network formation(GO:0051639)
0.1	2.6	GO:0050906	detection of stimulus involved in sensory perception(GO:0050906)
0.0	2.6	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
0.0	2.6	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.0	2.5	GO:0050657	nucleic acid transport(GO:0050657) RNA transport(GO:0050658) establishment of RNA localization(GO:0051236)

Showing 1 to 10 of 289 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.6	GO:0005794	Golgi apparatus(GO:0005794)
0.0	3.4	GO:0000786	nucleosome(GO:0000786)
0.0	3.2	GO:0005802	trans-Golgi network(GO:0005802)
0.1	2.6	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	2.6	GO:0031901	early endosome membrane(GO:0031901)
0.0	2.4	GO:0005871	kinesin complex(GO:0005871)
0.0	2.4	GO:0036064	ciliary basal body(GO:0036064)
0.0	2.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	2.3	GO:0043025	neuronal cell body(GO:0043025)
0.0	2.0	GO:0035097	histone methyltransferase complex(GO:0035097)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.5	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	6.6	GO:0005125	cytokine activity(GO:0005125)
0.0	5.8	GO:0042393	histone binding(GO:0042393)
0.0	4.7	GO:0005096	GTPase activator activity(GO:0005096)
0.1	3.9	GO:0030145	manganese ion binding(GO:0030145)
0.0	3.9	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	3.8	GO:0000049	tRNA binding(GO:0000049)
0.0	3.6	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.7	3.4	GO:0009374	biotin binding(GO:0009374)
0.2	3.3	GO:0033691	sialic acid binding(GO:0033691)

Showing 1 to 10 of 195 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.2	1.7	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	1.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	1.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	1.6	PID FOXO PATHWAY	FoxO family signaling
0.1	1.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	1.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.4	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	2.0	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	2.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	1.9	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	1.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	1.8	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.3	1.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	1.5	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	1.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	1.4	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER

Showing 1 to 10 of 72 entries

Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.97

Motif logo

Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Activity-expression correlation:

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: