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PRJNA195909:zebrafish embryo and larva development
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Results for pou3f1
Z-value: 2.08
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Transcription factors associated with pou3f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pou3f1 | dr11_v1_chr16_+_33593116_33593116 | 0.94 | 1.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_31372639 Show fit | 6.48 |
ENSDART00000179908
ENSDART00000135620 ENSDART00000053367 |
high mobility group nucleosomal binding domain 3 |
|
| chr6_+_4539953 Show fit | 4.97 |
ENSDART00000025031
|
POU class 4 homeobox 1 |
|
| chr3_-_32817274 Show fit | 4.78 |
ENSDART00000142582
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr21_+_30563115 Show fit | 3.98 |
ENSDART00000028566
|
si:ch211-200p22.4 |
|
| chr21_+_26390549 Show fit | 3.74 |
ENSDART00000185643
|
thymosin, beta |
|
| chr9_+_54178475 Show fit | 3.34 |
ENSDART00000104475
|
thymosin, beta 4 x |
|
| chr23_+_21473103 Show fit | 3.22 |
ENSDART00000142921
|
si:ch73-21g5.7 |
|
| chr2_+_55982940 Show fit | 3.20 |
ENSDART00000097753
ENSDART00000097751 |
nicotinamide riboside kinase 2 |
|
| chr4_-_16406737 Show fit | 3.02 |
ENSDART00000013085
|
decorin |
|
| chr8_+_13503377 Show fit | 2.98 |
ENSDART00000034740
ENSDART00000167187 |
fucosyltransferase 9d |
Network of associatons between targets according to the STRING database.
First level regulatory network of pou3f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 2.2 | 6.5 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.4 | 5.8 | GO:0036065 | fucosylation(GO:0036065) |
| 0.2 | 5.6 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.5 | 5.2 | GO:0034672 | anterior/posterior pattern specification involved in pronephros development(GO:0034672) anterior/posterior pattern specification involved in kidney development(GO:0072098) |
| 0.9 | 4.4 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.5 | 3.9 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 3.9 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.9 | 3.7 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.9 | 3.7 | GO:0021742 | abducens nucleus development(GO:0021742) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 4.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.4 | 4.0 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894) |
| 0.0 | 3.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 3.5 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 3.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.8 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 2.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 2.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 2.1 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 15.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 7.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.3 | 7.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.3 | 5.8 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.2 | 4.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 4.0 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 3.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.5 | 3.2 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.0 | 2.7 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 1.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 3.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 2.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.7 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |