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PRJNA195909:zebrafish embryo and larva development

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Results for plag1+plagx

Z-value: 1.81

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Transcription factors associated with plag1+plagx

Gene Symbol Gene ID Gene Info
plagx
ENSDARG00000036855 pleiomorphic adenoma gene X
plag1
ENSDARG00000051926 pleiomorphic adenoma gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
plag1dr11_v1_chr7_+_58736889_587368890.881.6e-03Click!
plagxdr11_v1_chr23_+_32011768_320117680.771.5e-02Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22310919 8.07 ENSDART00000108719
crygm2d10
crystallin, gamma M2d10
chr2_+_2470687 5.52 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr7_+_39399747 4.05 ENSDART00000147037
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr12_-_25916530 3.63 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr23_+_44732863 3.48 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr24_+_35564668 3.24 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta
chr19_-_4010263 3.19 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr1_+_49568335 2.71 ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr5_-_14326959 2.67 ENSDART00000137355
tet3
tet methylcytosine dioxygenase 3
chr4_+_21741228 2.37 ENSDART00000112035
ENSDART00000127664
myf5
myogenic factor 5
chr21_+_7823146 2.25 ENSDART00000030579
crhbp
corticotropin releasing hormone binding protein
chr16_-_36798783 2.23 ENSDART00000145697
calb1
calbindin 1
chr1_+_47446032 2.13 ENSDART00000126904
ENSDART00000007262
gja8b
gap junction protein alpha 8 paralog b
chr4_+_19534833 2.13 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr22_-_15957041 2.10 ENSDART00000149236
ENSDART00000187500
ENSDART00000176304
ENSDART00000080047
ENSDART00000190068
eps15l1a
epidermal growth factor receptor pathway substrate 15-like 1a
chr21_+_5801105 1.85 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr11_+_13630107 1.85 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr12_-_30345444 1.76 ENSDART00000152985
vwa2
von Willebrand factor A domain containing 2
chr7_+_44608224 1.75 ENSDART00000005033
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr7_+_44608478 1.68 ENSDART00000149981
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr12_+_16440708 1.47 ENSDART00000113810
ankrd1b
ankyrin repeat domain 1b (cardiac muscle)
chr6_-_35401282 1.46 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr16_+_11834516 1.45 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr20_+_28245164 1.42 ENSDART00000103320
dll4
delta-like 4 (Drosophila)
chr23_+_43954809 1.34 ENSDART00000164080
corin
corin, serine peptidase
chr14_-_1958994 1.31 ENSDART00000161783
pcdh2g5
protocadherin 2 gamma 5
chr4_+_9400012 1.14 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr3_+_18795570 1.10 ENSDART00000042368
fahd1
fumarylacetoacetate hydrolase domain containing 1
chr19_-_3193912 1.02 ENSDART00000133159
si:ch211-133n4.6
si:ch211-133n4.6
chr8_-_25247284 0.80 ENSDART00000132697
gnat2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr19_+_37620342 0.76 ENSDART00000158960
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr2_+_13069168 0.67 ENSDART00000192832
prkag2b
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr24_-_26383978 0.66 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr12_+_22657925 0.57 ENSDART00000153048
si:dkey-219e21.4
si:dkey-219e21.4
chr4_+_6572364 0.55 ENSDART00000122574
ppp1r3aa
protein phosphatase 1, regulatory subunit 3Aa
chr5_+_38886499 0.53 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr6_-_29105727 0.52 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr12_-_46112892 0.50 ENSDART00000187128
ENSDART00000114268
zgc:153932
zgc:153932
chr23_+_30859086 0.45 ENSDART00000053661
zgc:198371
zgc:198371
chr20_-_21910043 0.42 ENSDART00000152290
ENSDART00000109084
daam1b
dishevelled associated activator of morphogenesis 1b
chr2_+_51783120 0.37 ENSDART00000177559
crygn1
crystallin, gamma N1
chr7_-_41403022 0.36 ENSDART00000174285
BX322787.1

chr24_-_35534273 0.36 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr16_-_35586401 0.34 ENSDART00000169868
ENSDART00000166606
ENSDART00000162562
scmh1
Scm polycomb group protein homolog 1
chr7_+_568819 0.28 ENSDART00000173716
nrxn2b
neurexin 2b
chr19_-_20093341 0.27 ENSDART00000129917
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr14_-_2209742 0.26 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr22_+_8551813 0.16 ENSDART00000129690
zmp:0000000984
zmp:0000000984
chr22_-_4798738 0.12 ENSDART00000114465
zgc:195170
zgc:195170
chr20_-_14665002 0.11 ENSDART00000152816
scrn2
secernin 2
chr24_-_21490628 0.10 ENSDART00000181546
atp8a2
ATPase phospholipid transporting 8A2
chr19_+_11260143 0.02 ENSDART00000187771
si:ch73-171o20.1
si:ch73-171o20.1
chr10_-_167782 0.01 ENSDART00000108780
erg
v-ets avian erythroblastosis virus E26 oncogene homolog
chr10_-_36240806 0.01 ENSDART00000171468
or109-2
odorant receptor, family D, subfamily 109, member 2
chr19_-_32944050 0.01 ENSDART00000137611
azin1b
antizyme inhibitor 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.7 2.2 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.6 2.2 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.5 2.7 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.5 1.4 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.2 3.5 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 3.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 4.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.8 GO:0050909 sensory perception of taste(GO:0050909)
0.1 2.3 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 6.4 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.9 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.6 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.7 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.8 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 2.7 GO:0008544 epidermis development(GO:0008544)
0.0 0.4 GO:0006301 postreplication repair(GO:0006301)
0.0 1.4 GO:0019722 calcium-mediated signaling(GO:0019722)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 2.1 GO:0005922 connexon complex(GO:0005922)
0.1 5.9 GO:0043679 axon terminus(GO:0043679)
0.1 2.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 4.1 GO:0005861 troponin complex(GO:0005861)
0.1 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:1903136 cuprous ion binding(GO:1903136)
0.7 2.2 GO:0005499 vitamin D binding(GO:0005499)
0.4 2.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.4 2.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.4 1.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.1 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 3.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 8.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 2.2 GO:0017046 peptide hormone binding(GO:0017046)
0.1 1.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:2001069 glycogen binding(GO:2001069)
0.0 1.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 10.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.7 GO:0046332 SMAD binding(GO:0046332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation