ISMARA results: plag1+plagx

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PRJNA195909:zebrafish embryo and larva development

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Results for plag1+plagx

Z-value: 1.81

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Transcription factors associated with plag1+plagx

Gene Symbol	Gene ID	Gene Info
plagx NCBI UniProt	ENSDARG00000036855	pleiomorphic adenoma gene X
plag1 NCBI UniProt	ENSDARG00000051926	pleiomorphic adenoma gene 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
plag1	dr11_v1_chr7_+_58736889_58736889	0.88	1.6e-03	Click!
plagx	dr11_v1_chr23_+_32011768_32011768	0.77	1.5e-02	Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_22310919 Show fit	8.07	ENSDART00000108719	crygm2d10 NCBI UniProt Show fit	crystallin, gamma M2d10
chr2_+_2470687 Show fit	5.52	ENSDART00000184024 ENSDART00000061955	myl13 NCBI UniProt Show fit	myosin, light chain 13
chr7_+_39399747 Show fit	4.05	ENSDART00000147037	tnni2b.1 NCBI UniProt Show fit	troponin I type 2b (skeletal, fast), tandem duplicate 1
chr12_-_25916530 Show fit	3.63	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr23_+_44732863 Show fit	3.48	ENSDART00000160044 ENSDART00000172268	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr24_+_35564668 Show fit	3.24	ENSDART00000122734	cebpd NCBI UniProt Show fit	CCAAT/enhancer binding protein (C/EBP), delta
chr19_-_4010263 Show fit	3.19	ENSDART00000159605 ENSDART00000165541	map7d1b NCBI UniProt Show fit	MAP7 domain containing 1b
chr1_+_49568335 Show fit	2.71	ENSDART00000142957	col17a1a NCBI UniProt Show fit	collagen, type XVII, alpha 1a
chr5_-_14326959 Show fit	2.67	ENSDART00000137355	tet3 NCBI UniProt Show fit	tet methylcytosine dioxygenase 3
chr4_+_21741228 Show fit	2.37	ENSDART00000112035 ENSDART00000127664	myf5 NCBI UniProt Show fit	myogenic factor 5

Showing 1 to 10 of 55 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0002088	lens development in camera-type eye(GO:0002088)
0.1	4.1	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	3.6	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.2	3.5	GO:0071436	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.5	2.7	GO:0032656	interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.0	2.7	GO:0008544	epidermis development(GO:0008544)
0.8	2.4	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	2.3	GO:0010669	epithelial structure maintenance(GO:0010669)
0.7	2.2	GO:0090278	negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.6	2.2	GO:1900271	regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)

Showing 1 to 10 of 19 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	GO:0043679	axon terminus(GO:0043679)
0.1	4.1	GO:0005861	troponin complex(GO:0005861)
0.3	3.5	GO:0090533	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2	2.1	GO:0005922	connexon complex(GO:0005922)
0.1	2.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	1.9	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	1.8	GO:0005604	basement membrane(GO:0005604)
0.0	0.8	GO:0001917	photoreceptor inner segment(GO:0001917)
0.1	0.7	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)

Showing 1 to 10 of 10 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.6	GO:0005509	calcium ion binding(GO:0005509)
0.1	8.1	GO:0005212	structural constituent of eye lens(GO:0005212)
1.2	3.6	GO:1903136	cuprous ion binding(GO:1903136)
0.2	3.5	GO:0001671	ATPase activator activity(GO:0001671)
0.0	3.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.4	2.7	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.7	2.2	GO:0005499	vitamin D binding(GO:0005499)
0.1	2.2	GO:0017046	peptide hormone binding(GO:0017046)
0.4	2.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	1.9	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	2.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	2.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.4	PID NOTCH PATHWAY	Notch signaling pathway
0.1	0.8	PID CONE PATHWAY	Visual signal transduction: Cones

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	1.4	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.8	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation

Showing 1 to 4 of 4 entries

Results for plag1+plagx

Z-value: 1.81

Motif logo

Transcription factors associated with plag1+plagx

Activity-expression correlation:

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: