ISMARA results: pitx2

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PRJNA195909:zebrafish embryo and larva development

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Results for pitx2

Z-value: 1.55

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Transcription factors associated with pitx2

Gene Symbol	Gene ID	Gene Info
pitx2 NCBI UniProt	ENSDARG00000036194	paired-like homeodomain 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pitx2	dr11_v1_chr14_+_36218072_36218072	0.87	2.5e-03	Click!

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_45282858 Show fit	7.64	ENSDART00000162353	CABZ01073265.1 NCBI UniProt Show fit
chr19_-_5345930 Show fit	3.46	ENSDART00000066620 ENSDART00000151398	krtt1c19e NCBI UniProt Show fit	keratin type 1 c19e
chr13_+_24280380 Show fit	2.94	ENSDART00000184115	acta1b NCBI UniProt Show fit	actin, alpha 1b, skeletal muscle
chr2_-_31767827 Show fit	2.65	ENSDART00000114928	and2 NCBI UniProt Show fit	actinodin2
chr1_+_7546259 Show fit	2.50	ENSDART00000015732	mylz3 NCBI UniProt Show fit	myosin, light polypeptide 3, skeletal muscle
chr16_-_45910050 Show fit	2.35	ENSDART00000133213	afp4 NCBI UniProt Show fit	antifreeze protein type IV
chr25_+_21833287 Show fit	2.29	ENSDART00000187606	ckmt1 NCBI UniProt Show fit	creatine kinase, mitochondrial 1
chr4_+_6643421 Show fit	2.28	ENSDART00000099462	gpr85 NCBI UniProt Show fit	G protein-coupled receptor 85
chr22_-_23625351 Show fit	2.26	ENSDART00000192588 ENSDART00000163423	cfhl4 NCBI UniProt Show fit	complement factor H like 4
chr7_+_20505311 Show fit	2.22	ENSDART00000187335	si:dkey-19b23.12 NCBI UniProt Show fit	si:dkey-19b23.12

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.1	GO:0007160	cell-matrix adhesion(GO:0007160)
0.3	3.6	GO:0042396	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0	2.9	GO:0048741	myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.1	2.4	GO:0048570	notochord morphogenesis(GO:0048570)
0.1	2.3	GO:0018149	peptide cross-linking(GO:0018149)
0.1	2.3	GO:0060030	dorsal convergence(GO:0060030)
0.2	2.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.4	2.1	GO:0010873	regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1	2.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4	2.0	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)

Showing 1 to 10 of 103 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.0	GO:0005869	dynactin complex(GO:0005869)
0.0	3.5	GO:0005882	intermediate filament(GO:0005882)
0.2	2.7	GO:0030315	T-tubule(GO:0030315)
0.1	2.3	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	2.2	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	2.1	GO:0042627	chylomicron(GO:0042627)
0.0	1.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.2	1.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1	1.8	GO:0031430	M band(GO:0031430)
0.1	1.6	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	3.8	GO:0030414	peptidase inhibitor activity(GO:0030414)
0.3	3.6	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3	2.5	GO:0001972	retinoic acid binding(GO:0001972)
0.1	2.3	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1	2.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.4	2.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	2.0	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1	1.8	GO:0001671	ATPase activator activity(GO:0001671)
0.4	1.7	GO:0003884	D-amino-acid oxidase activity(GO:0003884)

Showing 1 to 10 of 74 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.8	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.6	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.4	PID RAS PATHWAY	Regulation of Ras family activation
0.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	ST ADRENERGIC	Adrenergic Pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	2.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	1.4	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	1.3	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	0.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.5	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 19 entries

Results for pitx2

Z-value: 1.55

Motif logo

Transcription factors associated with pitx2

Activity-expression correlation:

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: