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PRJNA195909:zebrafish embryo and larva development

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Results for pitx2

Z-value: 1.55

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Transcription factors associated with pitx2

Gene Symbol Gene ID Gene Info
ENSDARG00000036194 paired-like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx2dr11_v1_chr14_+_36218072_362180720.872.5e-03Click!

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_45282858 7.64 ENSDART00000162353

chr19_-_5345930 3.46 ENSDART00000066620
ENSDART00000151398
keratin type 1 c19e
chr13_+_24280380 2.94 ENSDART00000184115
actin, alpha 1b, skeletal muscle
chr2_-_31767827 2.65 ENSDART00000114928
actinodin2
chr1_+_7546259 2.50 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr16_-_45910050 2.35 ENSDART00000133213
antifreeze protein type IV
chr25_+_21833287 2.29 ENSDART00000187606
creatine kinase, mitochondrial 1
chr4_+_6643421 2.28 ENSDART00000099462
G protein-coupled receptor 85
chr22_-_23625351 2.26 ENSDART00000192588
ENSDART00000163423
complement factor H like 4
chr7_+_20505311 2.22 ENSDART00000187335
si:dkey-19b23.12
chr12_-_35949936 2.14 ENSDART00000192583

chr5_+_37978501 2.06 ENSDART00000012050
apolipoprotein A-Ia
chr6_-_54126463 2.04 ENSDART00000161059
tumor suppressor candidate 2a
chr21_+_20715020 1.99 ENSDART00000015224
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr7_-_8408014 1.87 ENSDART00000112492
zgc:194686
chr11_+_6116503 1.86 ENSDART00000176170
nuclear receptor subfamily 2, group F, member 6b
chr1_+_31942961 1.79 ENSDART00000007522
anosmin 1a
chr6_+_29217392 1.78 ENSDART00000006386
ATPase Na+/K+ transporting subunit beta 1a
chr23_-_45682136 1.77 ENSDART00000164646
family with sequence similarity 160, member A1b
chr5_-_20205075 1.68 ENSDART00000051611
D-amino-acid oxidase, tandem duplicate 3
chr14_+_6423973 1.66 ENSDART00000051556
ATP-binding cassette, sub-family A (ABC1), member 1B
chr19_+_10339538 1.66 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr18_-_46354269 1.62 ENSDART00000010813
forkhead box A3
chr9_+_307863 1.58 ENSDART00000163474
SH3 and cysteine rich domain 3
chr20_-_29482492 1.58 ENSDART00000178308
actin, alpha, cardiac muscle 1a
chr24_+_36636208 1.58 ENSDART00000139211
si:ch73-334d15.4
chr19_-_15855427 1.57 ENSDART00000133059
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr16_-_28836523 1.53 ENSDART00000108596
ENSDART00000142920
perilipin 6
chr8_-_22964486 1.50 ENSDART00000112381
elastin microfibril interfacer 3a
chr1_+_33322555 1.50 ENSDART00000113486
matrix-remodelling associated 5a
chr12_+_316238 1.50 ENSDART00000187492
recoverin b
chr2_-_2020044 1.49 ENSDART00000024135
tubulin, beta 2A class IIa
chr6_+_2093206 1.42 ENSDART00000114314
transglutaminase 2b
chr7_+_24115082 1.40 ENSDART00000182718
mitochondrial ribosomal protein L52
chr5_-_72125551 1.38 ENSDART00000149412
SET and MYND domain containing 1a
chr23_+_28731379 1.37 ENSDART00000047378
cortistatin
chr15_-_20024205 1.34 ENSDART00000161379
autism susceptibility candidate 2b
chr25_+_21832938 1.30 ENSDART00000148299
creatine kinase, mitochondrial 1
chr5_-_46505691 1.30 ENSDART00000111589
ENSDART00000122966
ENSDART00000166907
hyaluronan and proteoglycan link protein 1a
chr13_-_30028103 1.29 ENSDART00000183889
stearoyl-CoA desaturase b
chr25_+_6306885 1.28 ENSDART00000142705
ENSDART00000067510
cellular retinoic acid binding protein 1a
chr17_+_996509 1.25 ENSDART00000158830
cytochrome P450, family 1, subfamily C, polypeptide 2
chr19_+_19747430 1.25 ENSDART00000166129
homeobox A9a
chr14_-_2270973 1.24 ENSDART00000180729
protocadherin 2 alpha b 9
chr24_+_24461341 1.22 ENSDART00000147658
basic helix-loop-helix family, member e22
chr12_+_9542124 1.21 ENSDART00000127952
prolyl 4-hydroxylase, alpha polypeptide I a
chr19_-_28283844 1.21 ENSDART00000151756
ENSDART00000079104
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr6_-_9581949 1.21 ENSDART00000144335
cytochrome P450, family 27, subfamily C, polypeptide 1
chr17_-_5583345 1.20 ENSDART00000035944
chloride intracellular channel 5a
chr8_-_54304381 1.16 ENSDART00000184177
rhodopsin
chr7_-_57933736 1.15 ENSDART00000142580
ankyrin 2b, neuronal
chr11_+_5926850 1.15 ENSDART00000104364
ribosomal protein S15
chr25_-_28384954 1.15 ENSDART00000073500
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr15_-_21014015 1.15 ENSDART00000144991
si:ch211-212c13.10
chr15_+_35043007 1.13 ENSDART00000086954
sestrin 3
chr13_-_16222388 1.12 ENSDART00000182861
zgc:110045
chr10_-_43771447 1.12 ENSDART00000052307
arrestin domain containing 3b
chr17_-_31659670 1.12 ENSDART00000030448
visual system homeobox 2
chr10_+_10351685 1.09 ENSDART00000109432
cerebral endothelial cell adhesion molecule
chr10_+_21511495 1.07 ENSDART00000178395

chr7_+_24114694 1.05 ENSDART00000127177
mitochondrial ribosomal protein L52
chr21_+_41743493 1.03 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr24_+_20373605 1.02 ENSDART00000112349
phospholipase C, delta 1a
chr25_+_10458990 0.99 ENSDART00000130354
ENSDART00000044738
RIC8 guanine nucleotide exchange factor A
chr15_-_25584888 0.98 ENSDART00000127571
si:dkey-54n8.2
chr11_+_6116096 0.97 ENSDART00000159680
nuclear receptor subfamily 2, group F, member 6b
chr23_-_15330168 0.96 ENSDART00000035865
ENSDART00000143635
sulfatase 2b
chr7_+_15872357 0.96 ENSDART00000165757
paired box 6b
chr20_-_20533865 0.95 ENSDART00000125039
SIX homeobox 6b
chr16_-_46660680 0.95 ENSDART00000159209
ENSDART00000191929
transmembrane protein 176l.4
chr23_+_3607305 0.94 ENSDART00000186190
si:dkey-9l20.3
chr7_-_29021757 0.94 ENSDART00000086905
neuritin 1-like b
chr23_+_3591690 0.94 ENSDART00000180822
si:dkey-9l20.3
chr18_+_6054816 0.94 ENSDART00000113668
si:ch73-386h18.1
chr8_-_22965214 0.92 ENSDART00000148178
elastin microfibril interfacer 3a
chr18_+_507618 0.92 ENSDART00000159464
neural precursor cell expressed, developmentally down-regulated 4a
chr9_+_34127005 0.92 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr23_+_3627379 0.92 ENSDART00000187279
si:dkey-9l20.3
chr6_-_58149165 0.91 ENSDART00000170752
TOX high mobility group box family member 2
chr8_-_18239494 0.91 ENSDART00000079989
ENSDART00000022959
guanylate kinase 1b
chr2_-_17947389 0.91 ENSDART00000190089
ENSDART00000191872
ENSDART00000184039
ENSDART00000179791
protein tyrosine phosphatase, receptor type, f, b
chr23_+_3609535 0.90 ENSDART00000191440
si:dkey-9l20.3
chr15_-_21014270 0.90 ENSDART00000154019
si:ch211-212c13.10
chr1_-_52494122 0.90 ENSDART00000131407
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr20_-_49657134 0.89 ENSDART00000151248
collagen, type XII, alpha 1b
chr13_-_24448278 0.89 ENSDART00000057584
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr23_+_3618454 0.88 ENSDART00000189393
si:dkey-9l20.3
chr12_+_48216662 0.87 ENSDART00000187369
leucine rich repeat containing 20
chr23_+_43255328 0.87 ENSDART00000102712
transglutaminase 2, C polypeptide A
chr18_-_40509006 0.87 ENSDART00000021372
cholinergic receptor, nicotinic, alpha 5
chr9_-_23747264 0.85 ENSDART00000141461
ENSDART00000010311
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10
chr10_-_43294933 0.85 ENSDART00000062631
hyaluronan and proteoglycan link protein 1b
chr20_+_36233873 0.85 ENSDART00000131867
cornichon family AMPA receptor auxiliary protein 3
chr22_+_5687615 0.85 ENSDART00000133241
ENSDART00000019854
ENSDART00000138102
deoxyribonuclease 1 like 4, tandem duplicate 2
chr10_+_15777064 0.84 ENSDART00000114483
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr6_+_21740672 0.83 ENSDART00000193734
lipoma HMGIC fusion partner-like 4a
chr3_-_25119839 0.82 ENSDART00000154724
chondroadherin-like a
chr19_-_9829965 0.82 ENSDART00000136842
ENSDART00000142766
calcium channel, voltage-dependent, gamma subunit 8a
chr15_-_12319065 0.82 ENSDART00000162973
ENSDART00000170543
FXYD domain containing ion transport regulator 6
chr19_-_3193912 0.80 ENSDART00000133159
si:ch211-133n4.6
chr3_+_37574885 0.80 ENSDART00000055225
wingless-type MMTV integration site family, member 9B
chr10_+_15777258 0.79 ENSDART00000140511
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr19_+_12762887 0.79 ENSDART00000139909
melanocortin 5a receptor
chr8_+_17184602 0.78 ENSDART00000050228
ENSDART00000140531
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr16_+_28383758 0.78 ENSDART00000059038
ENSDART00000141061
integrin, alpha 8
chr18_+_507835 0.78 ENSDART00000189701
neural precursor cell expressed, developmentally down-regulated 4a
chr9_-_42989297 0.78 ENSDART00000126871
titin, tandem duplicate 2
chr16_+_42018367 0.78 ENSDART00000058613
Fli-1 proto-oncogene, ETS transcription factor b
chr21_+_19648814 0.78 ENSDART00000048581
fibroblast growth factor 10a
chr23_+_9220436 0.78 ENSDART00000033663
ENSDART00000139870
ribosomal protein S21
chr23_+_3616224 0.76 ENSDART00000190917
si:dkey-9l20.3
chr5_+_52067723 0.76 ENSDART00000166902
SET binding protein 1
chr25_-_13839743 0.75 ENSDART00000158780
mitogen-activated protein kinase 8 interacting protein 1a
chr6_+_37894914 0.75 ENSDART00000148817
oculocutaneous albinism II
chr23_+_3611765 0.75 ENSDART00000181481
si:dkey-9l20.3
chr7_+_57866292 0.75 ENSDART00000138757
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr6_-_54179860 0.74 ENSDART00000164283
ribosomal protein S10
chr9_+_21401189 0.73 ENSDART00000062669
connexin 30.3
chr12_+_47917971 0.73 ENSDART00000185933
thymus, brain and testes associated
chr18_-_17001056 0.73 ENSDART00000112627
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr23_+_37090889 0.72 ENSDART00000074406
UBX domain protein 10
chr3_+_7001608 0.72 ENSDART00000127809
zmp:0000001228
chr23_+_3613994 0.71 ENSDART00000183763
si:dkey-9l20.3
chr23_+_3622920 0.70 ENSDART00000183091
si:dkey-9l20.3
chr19_-_18626515 0.70 ENSDART00000160624
ribosomal protein S18
chr23_+_3620618 0.69 ENSDART00000190126
si:dkey-9l20.3
chr18_-_17000842 0.69 ENSDART00000079832
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr19_+_37701450 0.68 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr9_-_32753535 0.68 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr11_-_44409856 0.68 ENSDART00000162886
interleukin 1 receptor accessory protein-like 1b
chr23_-_28239750 0.68 ENSDART00000003548
zinc finger protein 385A
chr15_+_618081 0.68 ENSDART00000181518
si:ch211-210b2.1
chr13_-_30027730 0.66 ENSDART00000044009
stearoyl-CoA desaturase b
chr5_+_17727310 0.66 ENSDART00000147657
fibrosin-like 1
chr11_-_36051004 0.66 ENSDART00000025033
glutathione peroxidase 1a
chr6_+_39506043 0.65 ENSDART00000086260

chr8_+_45003659 0.65 ENSDART00000132663
si:ch211-163b2.4
chr16_+_46695777 0.65 ENSDART00000169767
RAB25, member RAS oncogene family b
chr9_-_9998087 0.64 ENSDART00000124423
UDP glucuronosyltransferase 1 family a, b
chr19_-_31802296 0.64 ENSDART00000103640
hes-related family bHLH transcription factor with YRPW motif 1
chr12_-_30345444 0.64 ENSDART00000152985
von Willebrand factor A domain containing 2
chr23_+_3587230 0.63 ENSDART00000055103
si:dkey-9l20.3
chr8_+_27807974 0.63 ENSDART00000078509
capping protein (actin filament) muscle Z-line, alpha 1b
chr23_+_3596401 0.63 ENSDART00000185908
si:dkey-9l20.3
chr13_-_40411908 0.62 ENSDART00000057094
ENSDART00000150091
NK2 homeobox 3
chr23_-_13295923 0.62 ENSDART00000189214
ENSDART00000165432
Danio rerio uncharacterized LOC100001444 (LOC100001444), mRNA.
chr23_+_3602779 0.61 ENSDART00000013629
si:dkey-9l20.3
chr8_+_694218 0.61 ENSDART00000147753
ring finger protein 165b
chr1_-_26293203 0.61 ENSDART00000180140
CXXC finger 4
chr11_-_4235811 0.60 ENSDART00000121716
si:ch211-236d3.4
chr9_-_9980704 0.60 ENSDART00000130243
ENSDART00000193475
UDP glucuronosyltransferase 1 family a, b
chr13_+_50151407 0.59 ENSDART00000031858
G protein-coupled receptor 137Ba
chr3_-_28828569 0.57 ENSDART00000167679
si:ch211-76l23.4
chr14_-_32884138 0.57 ENSDART00000105726
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr7_-_22132265 0.57 ENSDART00000125284
ENSDART00000112978
neuroligin 2a
chr23_+_3598320 0.57 ENSDART00000189608
si:dkey-9l20.3
chr14_+_9009600 0.56 ENSDART00000133904
si:ch211-274f20.2
chr3_+_16762483 0.56 ENSDART00000132732
transmembrane protein 86B
chr2_+_36701322 0.56 ENSDART00000002510
golgi integral membrane protein 4b
chr9_-_1986014 0.54 ENSDART00000142842
homeobox D12a
chr21_+_10756154 0.54 ENSDART00000074833
retinal homeobox gene 3
chr25_+_35019693 0.54 ENSDART00000046218
filamin C, gamma a (actin binding protein 280)
chr23_+_3594171 0.53 ENSDART00000159609
si:dkey-9l20.3
chr12_+_30653047 0.53 ENSDART00000148562
thrombospondin 2b
chr15_-_23467750 0.52 ENSDART00000148804
PDZ domain containing 3a
chr3_+_12334509 0.52 ENSDART00000165796
GLIS family zinc finger 2b
chr5_-_38094130 0.52 ENSDART00000131831
si:ch211-284e13.4
chr24_-_27400630 0.52 ENSDART00000165760
chemokine (C-C motif) ligand 34b, duplicate 1
chr12_+_17106117 0.51 ENSDART00000149990
actin, alpha 2, smooth muscle, aorta
chr21_+_22630627 0.51 ENSDART00000193092
si:dkeyp-69c1.7
chr23_+_3589711 0.51 ENSDART00000187435
si:dkey-9l20.3
chr23_+_3600866 0.51 ENSDART00000184376
si:dkey-9l20.3
chr18_+_33725576 0.51 ENSDART00000146816
si:dkey-145c18.5
chr23_+_3625083 0.51 ENSDART00000184958
si:dkey-9l20.3
chr5_+_64840656 0.50 ENSDART00000073953
leucine rich repeat containing 8 VRAC subunit Ab
chr20_-_25369767 0.50 ENSDART00000180278
intersectin 2a
chr22_-_18491813 0.49 ENSDART00000105419
si:ch211-212d10.2
chr23_+_3605325 0.49 ENSDART00000182713
si:dkey-9l20.3
chr25_+_26844028 0.49 ENSDART00000127274
ENSDART00000156179
semaphorin 7A
chr11_+_45422206 0.49 ENSDART00000182548
HRAS-like suppressor
chr6_-_39344259 0.48 ENSDART00000104074
zgc:158846
chr4_-_9764767 0.48 ENSDART00000164328
ENSDART00000147699
microtubule associated monooxygenase, calponin and LIM domain containing 3b
chr1_-_26292897 0.48 ENSDART00000112899
ENSDART00000185410
CXXC finger 4
chr22_+_696931 0.47 ENSDART00000149712
ENSDART00000009756
G protein-coupled receptor 37 like 1a
chr7_+_30970045 0.47 ENSDART00000155974
tight junction protein 1a
chr21_+_22630297 0.46 ENSDART00000147175
si:dkeyp-69c1.7
chr9_-_43142636 0.46 ENSDART00000134349
ENSDART00000181835
coiled-coil domain containing 141
chr23_+_9867483 0.45 ENSDART00000023099
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr11_-_29563437 0.45 ENSDART00000163958
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr5_-_67145505 0.44 ENSDART00000011295
retinal outer segment membrane protein 1a
chr16_+_26863414 0.43 ENSDART00000140673
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr24_-_21258945 0.43 ENSDART00000111025
BOC cell adhesion associated, oncogene regulated
chr23_+_3585251 0.43 ENSDART00000187356
si:dkey-9l20.3
chr23_+_13814978 0.43 ENSDART00000090864
leiomodin 3 (fetal)
chr6_-_36182115 0.42 ENSDART00000154639
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr19_-_40186328 0.42 ENSDART00000087474
EF-hand calcium binding domain 1
chr19_-_25271155 0.41 ENSDART00000104027
regulating synaptic membrane exocytosis 3
chr18_-_40508528 0.41 ENSDART00000185249
cholinergic receptor, nicotinic, alpha 5
chr14_-_2264494 0.41 ENSDART00000191149
protocadherin 2 alpha b 9
chr1_+_50613868 0.41 ENSDART00000111114
si:ch73-190m4.1

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0048785 hatching gland development(GO:0048785)
0.4 1.7 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.4 2.1 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.4 2.0 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.3 1.7 GO:0033700 phospholipid efflux(GO:0033700)
0.3 1.6 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.3 1.5 GO:0043476 pigment accumulation(GO:0043476)
0.3 3.6 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 1.6 GO:0003272 endocardial cushion formation(GO:0003272)
0.3 1.3 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.3 1.8 GO:0098773 skin epidermis development(GO:0098773)
0.2 1.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 2.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.4 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 1.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.2 0.8 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.2 0.6 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.2 0.8 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.2 0.5 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.2 0.5 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.7 GO:0021742 abducens nucleus development(GO:0021742)
0.2 1.8 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.2 0.5 GO:0060907 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907)
0.2 1.1 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.2 1.7 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.6 GO:0015865 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.7 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.8 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 1.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.8 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 14.1 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 1.3 GO:0035094 response to nicotine(GO:0035094)
0.1 1.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.3 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.9 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.3 GO:0032847 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
0.1 1.0 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 1.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.7 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 0.8 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 2.4 GO:0048570 notochord morphogenesis(GO:0048570)
0.1 0.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 2.3 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.3 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.8 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 1.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.2 GO:0031167 rRNA methylation(GO:0031167)
0.1 1.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 0.2 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 2.0 GO:0032543 mitochondrial translation(GO:0032543)
0.1 1.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 0.4 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.6 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.3 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.1 0.3 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.8 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.1 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.5 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.0 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.0 0.7 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0072012 renal system vasculature development(GO:0061437) kidney vasculature development(GO:0061440) glomerulus vasculature development(GO:0072012)
0.0 0.5 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.4 GO:1902882 regulation of response to oxidative stress(GO:1902882)
0.0 0.9 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.9 GO:0048741 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.2 GO:1903798 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0 0.3 GO:0048730 epidermis morphogenesis(GO:0048730)
0.0 0.5 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.3 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.1 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 0.7 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.2 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.4 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.9 GO:0007599 hemostasis(GO:0007599)
0.0 1.3 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 2.0 GO:0033333 fin development(GO:0033333)
0.0 0.5 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.8 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.8 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 1.3 GO:0031101 fin regeneration(GO:0031101)
0.0 0.5 GO:0016525 negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
0.0 0.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.2 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0060077 inhibitory synapse(GO:0060077)
0.3 5.0 GO:0005869 dynactin complex(GO:0005869)
0.2 1.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 2.7 GO:0030315 T-tubule(GO:0030315)
0.2 2.1 GO:0042627 chylomicron(GO:0042627)
0.2 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.1 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.6 GO:0097433 dense body(GO:0097433)
0.1 1.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.8 GO:0031430 M band(GO:0031430)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.1 2.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 2.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 3.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.7 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.3 GO:0043209 myelin sheath(GO:0043209)
0.0 0.4 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.7 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.4 1.3 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.4 2.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 1.7 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 2.5 GO:0001972 retinoic acid binding(GO:0001972)
0.3 1.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.3 3.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.2 1.0 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 0.7 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.2 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 0.5 GO:0010852 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.2 1.1 GO:0070728 leucine binding(GO:0070728)
0.2 0.8 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.6 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 2.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 1.8 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.8 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.8 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.9 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.6 GO:0016803 ether hydrolase activity(GO:0016803)
0.1 1.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.4 GO:0004096 catalase activity(GO:0004096)
0.0 1.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 5.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 3.8 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 1.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.4 GO:0005523 actin monomer binding(GO:0003785) tropomyosin binding(GO:0005523)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 ST ADRENERGIC Adrenergic Pathway
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins