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PRJNA195909:zebrafish embryo and larva development

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Results for pitx1+pitx3

Z-value: 0.40

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Transcription factors associated with pitx1+pitx3

Gene Symbol Gene ID Gene Info
pitx3
ENSDARG00000070069 paired-like homeodomain 3
pitx1
ENSDARG00000116608 paired-like homeodomain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx1dr11_v1_chr21_+_45816030_45816030-0.665.3e-02Click!
pitx3dr11_v1_chr13_-_7573670_7573670-0.618.3e-02Click!

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_20695237 0.55 ENSDART00000112722
org
oogenesis-related gene
chr15_+_38299385 0.37 ENSDART00000142403
si:dkey-24p1.6
si:dkey-24p1.6
chr7_+_46020508 0.35 ENSDART00000170294
ccne1
cyclin E1
chr15_+_38299563 0.29 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr2_-_32738535 0.28 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr19_+_43523690 0.27 ENSDART00000113031
wasf2
WAS protein family, member 2
chr4_-_5077158 0.25 ENSDART00000155915
ahcyl2
adenosylhomocysteinase-like 2
chr17_+_16046132 0.25 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr15_-_8856785 0.25 ENSDART00000192816
rab4b
RAB4B, member RAS oncogene family
chr3_-_33175583 0.25 ENSDART00000126022
rarab
retinoic acid receptor, alpha b
chr4_-_65037243 0.24 ENSDART00000170059
si:ch211-283l16.1
si:ch211-283l16.1
chr8_+_16990120 0.23 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr14_+_1124409 0.23 ENSDART00000190043
ENSDART00000106708
ENSDART00000160246
sec24b
SEC24 homolog B, COPII coat complex component
chr2_-_31686353 0.23 ENSDART00000126177
ENSDART00000056679
e2f5
E2F transcription factor 5
chr17_+_16046314 0.21 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr17_+_23729717 0.21 ENSDART00000179026
zgc:91976
zgc:91976
chr15_-_45510977 0.21 ENSDART00000090596
fgf12b
fibroblast growth factor 12b
chr1_-_30762264 0.20 ENSDART00000085454
dis3
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
chr10_+_6013076 0.20 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr22_+_26703026 0.19 ENSDART00000158756
crebbpa
CREB binding protein a
chr19_+_2631565 0.19 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr19_-_10207103 0.18 ENSDART00000151629
znf865
zinc finger protein 865
chr20_-_42534504 0.17 ENSDART00000132310
rfx6
regulatory factor X, 6
chr20_+_29587995 0.17 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr15_+_11693624 0.16 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr16_+_3067134 0.16 ENSDART00000012048
cyb5r4
cytochrome b5 reductase 4
chr20_-_38525467 0.16 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr23_-_32334208 0.15 ENSDART00000053472
rnf41
ring finger protein 41
chr1_+_56180416 0.15 ENSDART00000089358
crb3b
crumbs homolog 3b
chr6_-_14040136 0.14 ENSDART00000065361
ENSDART00000179765
etv5b
ets variant 5b
chr7_+_53413445 0.14 ENSDART00000190480
znf609b
zinc finger protein 609b
chr24_-_20321012 0.14 ENSDART00000163683
map3k20
mitogen-activated protein kinase kinase kinase 20
chr20_-_1847433 0.14 ENSDART00000164211
CABZ01065425.1

chr13_-_29505604 0.14 ENSDART00000110005
cdhr1a
cadherin-related family member 1a
chr8_+_23105117 0.13 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr8_+_4337312 0.12 ENSDART00000182228
myl2b
myosin, light chain 2b, regulatory, cardiac, slow
chr21_+_10756154 0.12 ENSDART00000074833
rx3
retinal homeobox gene 3
chr7_+_38962459 0.12 ENSDART00000173851
dgkza
diacylglycerol kinase, zeta a
chr11_+_25504215 0.12 ENSDART00000154213
tfe3b
transcription factor binding to IGHM enhancer 3b
chr18_+_7639401 0.12 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr10_+_28308376 0.11 ENSDART00000191216
ptrh2
peptidyl-tRNA hydrolase 2
chr10_-_10016348 0.11 ENSDART00000129151
strbp
spermatid perinuclear RNA binding protein
chr8_+_23356264 0.09 ENSDART00000145062
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr21_-_11632403 0.09 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
cast
calpastatin
chr6_+_41554794 0.08 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr16_+_29586468 0.08 ENSDART00000148926
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr24_-_20320480 0.08 ENSDART00000137366
map3k20
mitogen-activated protein kinase kinase kinase 20
chr23_+_22335407 0.08 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr5_+_60919378 0.08 ENSDART00000184915
doc2b
double C2-like domains, beta
chr11_-_27778831 0.07 ENSDART00000023823
cass4
Cas scaffolding protein family member 4
chr10_-_25628555 0.07 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr16_-_30847192 0.07 ENSDART00000191106
ENSDART00000128158
ptk2ab
protein tyrosine kinase 2ab
chr4_+_45357558 0.07 ENSDART00000150769
si:ch211-162i8.5
si:ch211-162i8.5
chr10_+_25204626 0.07 ENSDART00000024514
chordc1b
cysteine and histidine-rich domain (CHORD) containing 1b
chr18_-_31916845 0.06 ENSDART00000165908
olfcs2
olfactory receptor C family, s2
chr3_-_33574576 0.06 ENSDART00000184881
CR847537.1

chr21_+_1143141 0.06 ENSDART00000178294
CABZ01086139.1

chr9_+_30633184 0.06 ENSDART00000191310
tbc1d4
TBC1 domain family, member 4
chr7_-_17780048 0.05 ENSDART00000183336
si:dkey-106g10.7
si:dkey-106g10.7
chr13_+_15838151 0.05 ENSDART00000008987
klc1a
kinesin light chain 1a
chr16_+_29586004 0.05 ENSDART00000149520
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr7_-_17779644 0.05 ENSDART00000128504
si:dkey-106g10.7
si:dkey-106g10.7
chr4_+_25692277 0.04 ENSDART00000047113
acot18
acyl-CoA thioesterase 18
chr17_-_29736019 0.04 ENSDART00000183483
ush2a
Usher syndrome 2A (autosomal recessive, mild)
chr16_-_51299061 0.03 ENSDART00000148677
serpinb1l4
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr23_+_44349252 0.03 ENSDART00000097644
ephb4b
eph receptor B4b
chr7_-_29534001 0.03 ENSDART00000124028
anxa2b
annexin A2b
chr16_-_25663846 0.02 ENSDART00000031304
derl1
derlin 1
chr24_-_38079261 0.02 ENSDART00000105662
crp1
C-reactive protein 1
chr5_+_59494079 0.02 ENSDART00000148727
gtf2ird1
GTF2I repeat domain containing 1
chr25_-_8030113 0.02 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr7_-_29021757 0.01 ENSDART00000086905
nrn1lb
neuritin 1-like b
chr20_+_38524827 0.01 ENSDART00000153021
znf512
zinc finger protein 512
chr7_-_66864756 0.01 ENSDART00000184462
ENSDART00000189424
ampd3a
adenosine monophosphate deaminase 3a
chr23_+_43849190 0.01 ENSDART00000017375
cnga1
cyclic nucleotide gated channel alpha 1
chr17_-_31308658 0.01 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr18_+_9323211 0.01 ENSDART00000166114
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr8_+_21010850 0.00 ENSDART00000100295
si:dkeyp-82a1.4
si:dkeyp-82a1.4
chr20_-_1141722 0.00 ENSDART00000152675
gabrr1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr17_+_25289431 0.00 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 0.2 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.2 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0000177 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC