ISMARA results: pitx1+pitx3

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PRJNA195909:zebrafish embryo and larva development

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Results for pitx1+pitx3

Z-value: 0.40

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Transcription factors associated with pitx1+pitx3

Gene Symbol	Gene ID	Gene Info
pitx3 NCBI UniProt	ENSDARG00000070069	paired-like homeodomain 3
pitx1 NCBI UniProt	ENSDARG00000116608	paired-like homeodomain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pitx1	dr11_v1_chr21_+_45816030_45816030	-0.66	5.3e-02	Click!
pitx3	dr11_v1_chr13_-_7573670_7573670	-0.61	8.3e-02	Click!

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_20695237 Show fit	0.55	ENSDART00000112722	org NCBI UniProt Show fit	oogenesis-related gene
chr15_+_38299385 Show fit	0.37	ENSDART00000142403	si:dkey-24p1.6 NCBI UniProt Show fit	si:dkey-24p1.6
chr7_+_46020508 Show fit	0.35	ENSDART00000170294	ccne1 NCBI UniProt Show fit	cyclin E1
chr15_+_38299563 Show fit	0.29	ENSDART00000099375	si:dkey-24p1.6 NCBI UniProt Show fit	si:dkey-24p1.6
chr2_-_32738535 Show fit	0.28	ENSDART00000135293	nrbp2a NCBI UniProt Show fit	nuclear receptor binding protein 2a
chr19_+_43523690 Show fit	0.27	ENSDART00000113031	wasf2 NCBI UniProt Show fit	WAS protein family, member 2
chr4_-_5077158 Show fit	0.25	ENSDART00000155915	ahcyl2 NCBI UniProt Show fit	adenosylhomocysteinase-like 2
chr17_+_16046132 Show fit	0.25	ENSDART00000155005	si:ch73-204p21.2 NCBI UniProt Show fit	si:ch73-204p21.2
chr15_-_8856785 Show fit	0.25	ENSDART00000192816	rab4b NCBI UniProt Show fit	RAB4B, member RAS oncogene family
chr3_-_33175583 Show fit	0.25	ENSDART00000126022	rarab NCBI UniProt Show fit	retinoic acid receptor, alpha b

Showing 1 to 10 of 80 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:2000601	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	0.2	GO:1902767	farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1	0.2	GO:0035773	insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:0003139	secondary heart field specification(GO:0003139)
0.0	0.2	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.2	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.0	0.2	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0060898	eye field cell fate commitment involved in camera-type eye formation(GO:0060898)

Showing 1 to 10 of 13 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097134	cyclin E1-CDK2 complex(GO:0097134)
0.0	0.3	GO:0031209	SCAR complex(GO:0031209)
0.0	0.2	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0000177	nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)

Showing 1 to 6 of 6 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	0.2	GO:0004421	hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0	0.2	GO:0047493	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.2	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 5 of 5 entries

Results for pitx1+pitx3

Z-value: 0.40

Motif logo

Transcription factors associated with pitx1+pitx3

Activity-expression correlation:

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: