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PRJNA195909:zebrafish embryo and larva development

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Results for phox2a

Z-value: 0.78

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Transcription factors associated with phox2a

Gene Symbol Gene ID Gene Info
phox2a
ENSDARG00000007406 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2adr11_v1_chr15_+_47440477_474404770.862.9e-03Click!

Activity profile of phox2a motif

Sorted Z-values of phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433518 2.43 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 2.32 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr8_+_16025554 1.95 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr12_-_35830625 1.52 ENSDART00000180028
CU459056.1

chr4_-_9891874 1.27 ENSDART00000067193
adm2a
adrenomedullin 2a
chr10_-_22918214 1.10 ENSDART00000163908
rnasekb
ribonuclease, RNase K b
chr4_+_21129752 1.01 ENSDART00000169764
syt1a
synaptotagmin Ia
chr2_+_2223837 0.89 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr2_+_50608099 0.83 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr11_-_42554290 0.83 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr21_+_28478663 0.80 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr13_+_255067 0.80 ENSDART00000102505
foxg1d
forkhead box G1d
chr14_+_17376940 0.80 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr22_-_10121880 0.72 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr16_-_25568512 0.67 ENSDART00000149411
atxn1b
ataxin 1b
chr23_+_43255328 0.65 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr21_-_42100471 0.64 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr9_+_21165484 0.54 ENSDART00000177286
si:rp71-68n21.9
si:rp71-68n21.9
chr16_-_11798994 0.47 ENSDART00000135408
cnfn
cornifelin
chr3_-_56541723 0.46 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr15_-_22074315 0.46 ENSDART00000149830
drd2a
dopamine receptor D2a
chr7_-_30174882 0.40 ENSDART00000110409
frmd5
FERM domain containing 5
chr2_-_9818640 0.40 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr11_-_2838699 0.35 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr5_-_30620625 0.34 ENSDART00000098273
tcnl
transcobalamin like
chr18_+_28106139 0.32 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr4_+_6032640 0.31 ENSDART00000157487
tfec
transcription factor EC
chr17_+_49281597 0.30 ENSDART00000155599
zgc:113176
zgc:113176
chr6_-_35779348 0.28 ENSDART00000191159
brinp3a.1
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr15_-_14552101 0.25 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr20_-_28642061 0.25 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr22_+_7738966 0.24 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr13_+_22476742 0.23 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr6_+_13117598 0.22 ENSDART00000104744
casp8l1
caspase 8, apoptosis-related cysteine peptidase, like 1
chr1_-_44704261 0.22 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr6_+_24420523 0.21 ENSDART00000185461
tgfbr3
transforming growth factor, beta receptor III
chr3_+_23692462 0.21 ENSDART00000145934
hoxb7a
homeobox B7a
chr15_+_5360407 0.16 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr21_+_32820175 0.16 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr10_+_42423318 0.14 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr1_-_19502322 0.14 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr17_-_200316 0.12 ENSDART00000190561
CABZ01083778.1

chr22_-_8725768 0.11 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
si:ch73-27e22.1
si:ch73-27e22.8
chr20_-_9095105 0.11 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr18_+_34362608 0.06 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr1_-_31171242 0.06 ENSDART00000190294
kcnq5b
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr9_-_32177117 0.02 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr17_-_10122204 0.02 ENSDART00000160751
BX088587.1

chr20_-_29864390 0.01 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.7 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.5 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.1 GO:1903817 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.8 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 1.1 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 2.0 GO:0043204 perikaryon(GO:0043204)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.5 GO:0098978 glutamatergic synapse(GO:0098978)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.6 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation