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PRJNA195909:zebrafish embryo and larva development

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Results for phf21ab+rfx5

Z-value: 0.48

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Transcription factors associated with phf21ab+rfx5

Gene Symbol Gene ID Gene Info
ENSDARG00000021378 PHD finger protein 21Ab
ENSDARG00000063258 regulatory factor X, 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx5dr11_v1_chr19_-_7495006_74950060.962.7e-05Click!
phf21abdr11_v1_chr25_-_7759453_7759525-0.462.1e-01Click!

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_45920 1.20 ENSDART00000040422
betaine-homocysteine methyltransferase
chr10_-_22797959 0.93 ENSDART00000183269
procollagen C-endopeptidase enhancer a
chr2_-_42958619 0.66 ENSDART00000144317
otoconin 90
chr5_-_54300725 0.57 ENSDART00000163048
solute carrier family 25, member 35
chr7_-_26924903 0.57 ENSDART00000124363
ALX homeobox 4a
chr10_-_43294933 0.56 ENSDART00000062631
hyaluronan and proteoglycan link protein 1b
chr19_+_43297546 0.52 ENSDART00000168002
lysosomal protein transmembrane 5
chr16_-_13516745 0.52 ENSDART00000145410
si:dkeyp-69b9.3
chr20_-_29787192 0.51 ENSDART00000125348
ENSDART00000048759
inhibitor of DNA binding 2b
chr16_+_40301056 0.50 ENSDART00000058578
R-spondin 3
chr14_+_6954579 0.50 ENSDART00000060998
NME/NM23 family member 5
chr23_+_45025909 0.41 ENSDART00000188105
high mobility group box 2b
chr4_-_75678082 0.40 ENSDART00000180201
si:dkey-165o8.1
chr22_+_34710473 0.40 ENSDART00000155906
4-hydroxy-2-oxoglutarate aldolase 1
chr10_-_37072776 0.39 ENSDART00000110835
myosin XVIIIAa
chr23_+_45538932 0.38 ENSDART00000135602
si:ch73-290k24.6
chr23_-_45539306 0.37 ENSDART00000161913

chr1_-_23274393 0.36 ENSDART00000147800
ENSDART00000130277
ENSDART00000054340
ENSDART00000054338
ribosomal protein L9
chr8_+_36288261 0.35 ENSDART00000191281

chr8_-_36412936 0.35 ENSDART00000159276
si:zfos-2070c2.3
chr8_-_32878228 0.31 ENSDART00000110897
si:dkey-56i24.1
chr22_+_34710036 0.30 ENSDART00000025820
4-hydroxy-2-oxoglutarate aldolase 1
chr18_+_8339596 0.30 ENSDART00000183323
ENSDART00000185397

chr3_-_29941357 0.29 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr7_-_26049282 0.28 ENSDART00000136389
ENSDART00000101124
ribonuclease, RNase K a
chr9_-_41077934 0.27 ENSDART00000100342
ankyrin and armadillo repeat containing
chr1_-_7570181 0.27 ENSDART00000103588
myxovirus (influenza) resistance A
chr21_-_17290941 0.26 ENSDART00000147993
growth factor independent 1B transcription repressor
chr13_-_16066997 0.25 ENSDART00000184790
spermatogenesis associated 48
chr4_-_330748 0.25 ENSDART00000067488
mitochondrial ribosomal protein S10
chr15_-_17619306 0.25 ENSDART00000184011
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr18_+_49225552 0.25 ENSDART00000135026
si:ch211-136a13.1
chr23_+_21964325 0.25 ENSDART00000140208
ENSDART00000135690
lactamase, beta-like 1a
chr21_+_40239192 0.24 ENSDART00000135857
odorant receptor, family F, subfamily 115, member 9
chr25_+_27873836 0.22 ENSDART00000163801
IQ motif and ubiquitin domain containing
chr18_+_8340886 0.21 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr7_+_26049818 0.21 ENSDART00000173611
si:dkey-6n21.12
chr19_+_27589201 0.21 ENSDART00000182060
si:dkeyp-46h3.1
chr15_+_24388782 0.21 ENSDART00000191661
ENSDART00000179995
ENSDART00000111226
seizure related 6 homolog b
chr4_-_76370630 0.20 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
chr20_+_3277620 0.19 ENSDART00000067397
ENSDART00000135194
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr7_-_56606752 0.18 ENSDART00000138714
sulfotransferase family 5A, member 1
chr25_+_27873671 0.17 ENSDART00000088817
IQ motif and ubiquitin domain containing
chr13_+_233482 0.16 ENSDART00000102511
cilia and flagella associated protein 36
chr19_-_7110617 0.15 ENSDART00000104838
proteasome subunit beta 8A
chr18_+_49411417 0.14 ENSDART00000028944
zmp:0000001073
chr20_+_39416729 0.14 ENSDART00000099993
ENSDART00000144133
Pim proto-oncogene, serine/threonine kinase, related 128
chr6_-_40352215 0.14 ENSDART00000103992
tubulin tyrosine ligase-like family, member 3
chr11_-_24458786 0.13 ENSDART00000089713
matrix-remodelling associated 8a
chr8_-_51635930 0.13 ENSDART00000015833
neuropeptide Y receptor Y8b
chr18_-_21640389 0.12 ENSDART00000100857
solute carrier family 38, member 8a
chr4_-_43613424 0.11 ENSDART00000171524
si:dkey-16p6.4
chr4_-_36033377 0.11 ENSDART00000164348
ENSDART00000187058
zgc:174180
chr8_+_50727220 0.11 ENSDART00000127062
early growth response 3
chr17_-_45040813 0.11 ENSDART00000075514
ectonucleoside triphosphate diphosphohydrolase 5a
chr14_-_16476863 0.11 ENSDART00000089021
calnexin
chr4_+_68939595 0.11 ENSDART00000168331
ENSDART00000193212
si:dkey-264f17.2
chr18_-_46063773 0.10 ENSDART00000078561
si:ch73-262h23.4
chr4_+_76440462 0.10 ENSDART00000174138
si:dkey-16p6.1
chr4_+_30788743 0.10 ENSDART00000184557
si:dkey-178j11.5
chr2_-_37862380 0.10 ENSDART00000186005
si:ch211-284o19.8
chr4_-_49982134 0.10 ENSDART00000186050
si:dkey-156k2.4
chr21_-_32097908 0.09 ENSDART00000147387
si:ch211-160j14.3
chr10_-_8434816 0.09 ENSDART00000108643
tectonic family member 1
chr11_+_1805421 0.09 ENSDART00000173143
low density lipoprotein receptor-related protein 1Aa
chr7_+_66822229 0.09 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr25_+_22719852 0.08 ENSDART00000088422
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr1_-_494280 0.08 ENSDART00000144406
excision repair cross-complementation group 5
chr8_-_36370552 0.06 ENSDART00000097932
ENSDART00000148323
si:busm1-104n07.3
chr5_+_38662125 0.06 ENSDART00000136949
si:dkey-58f10.13
chr20_+_39394308 0.05 ENSDART00000142554
Pim proto-oncogene, serine/threonine kinase, related 136
chr6_+_26309968 0.04 ENSDART00000153805
DAZ interacting zinc finger protein 1-like
chr23_+_41831224 0.04 ENSDART00000171885
sterol carrier protein 2b
chr20_+_39373480 0.03 ENSDART00000136714
Pim proto-oncogene, serine/threonine kinase, related 131
chr2_-_49978227 0.02 ENSDART00000142835
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b
chr18_-_8579907 0.02 ENSDART00000147284
si:ch211-220f12.1
chr20_+_43396318 0.02 ENSDART00000060910
Pim proto-oncogene, serine/threonine kinase, related 138
chr4_+_7822773 0.02 ENSDART00000171391
si:ch1073-67j19.2
chr10_+_36092564 0.02 ENSDART00000086490
SET and MYND domain containing 4
chr8_+_36142734 0.02 ENSDART00000159361
ENSDART00000161194
major histocompatibility complex class II integral membrane beta chain gene
chr5_+_58397646 0.01 ENSDART00000180759
hepatic and glial cell adhesion molecule
chr4_-_36032177 0.01 ENSDART00000170143
zgc:174180
chr20_+_9211237 0.01 ENSDART00000139527
si:ch211-59d15.4
chr21_+_40268527 0.00 ENSDART00000174350
odorant receptor, family F, subfamily 115, member 7
chr1_+_24366110 0.00 ENSDART00000139913
Pim proto-oncogene, serine/threonine kinase, related 178
chr3_-_7912661 0.00 ENSDART00000161400
tripartite motif containing 35-21
chr7_-_3011514 0.00 ENSDART00000169589
zgc:171695

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.1 0.5 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 0.5 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.1 0.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 1.2 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.7 GO:1903963 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.2 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.0 0.3 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.2 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.5 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0072506 phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle