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PRJNA195909:zebrafish embryo and larva development
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Results for pgr
Z-value: 1.92
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Transcription factors associated with pgr
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pgr | dr11_v1_chr18_+_41820039_41820039 | -0.32 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_21471022 Show fit | 3.60 |
ENSDART00000104206
|
hairy-related 4, tandem duplicate 2 |
|
| chr23_+_21459263 Show fit | 3.20 |
ENSDART00000104209
|
hairy-related 4, tandem duplicate 3 |
|
| chr9_-_22272181 Show fit | 3.17 |
ENSDART00000113174
|
crystallin, gamma M2d7 |
|
| chr25_+_31277415 Show fit | 3.15 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr23_-_21453614 Show fit | 2.72 |
ENSDART00000079274
|
hairy-related 4, tandem duplicate 1 |
|
| chr18_+_9171778 Show fit | 2.55 |
ENSDART00000101192
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D |
|
| chr23_-_45501177 Show fit | 2.50 |
ENSDART00000150103
|
collagen type XXIV alpha 1 |
|
| chr5_-_32308526 Show fit | 2.42 |
ENSDART00000193758
|
myosin, heavy polypeptide 1.1, skeletal muscle |
|
| chr9_-_22831836 Show fit | 2.39 |
ENSDART00000142585
|
nebulin |
|
| chr16_+_23921777 Show fit | 2.35 |
ENSDART00000163213
|
apolipoprotein A-IV b, tandem duplicate 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pgr
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.5 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.2 | 9.7 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.1 | 5.4 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 4.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 4.0 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 3.9 | GO:1903670 | regulation of sprouting angiogenesis(GO:1903670) |
| 0.7 | 3.3 | GO:0003261 | cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261) |
| 0.5 | 3.1 | GO:0038065 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065) |
| 0.0 | 3.0 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.2 | 2.9 | GO:0016203 | muscle attachment(GO:0016203) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 6.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 5.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 4.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 3.3 | GO:0030141 | secretory granule(GO:0030141) |
| 1.0 | 3.1 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.1 | 3.0 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 2.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 2.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 2.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.1 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.0 | 11.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 10.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 5.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 4.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 4.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 3.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 2.9 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.9 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 2.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 1.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 2.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 1.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |