Project
PRJNA195909:zebrafish embryo and larva development
Navigation
Downloads
Results for pdx1_pbx4
Z-value: 1.23
Motif logo
Transcription factors associated with pdx1_pbx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pbx4 | dr11_v1_chr3_+_53052769_53052769 | -0.81 | 8.8e-03 | Click! |
| pdx1 | dr11_v1_chr24_+_21684189_21684189 | -0.57 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_+_38301080 Show fit | 18.65 |
ENSDART00000105672
|
myosin binding protein C, fast type b |
|
| chr4_-_9909371 Show fit | 3.06 |
ENSDART00000102656
|
si:dkey-22l11.6 |
|
| chr13_-_5569562 Show fit | 2.56 |
ENSDART00000102576
|
Meis homeobox 1 b |
|
| chr3_+_23752150 Show fit | 2.42 |
ENSDART00000146636
|
homeobox B2a |
|
| chr1_+_16144615 Show fit | 2.22 |
ENSDART00000054707
|
tumor suppressor candidate 3 |
|
| chr13_-_5568928 Show fit | 2.19 |
ENSDART00000192679
|
Meis homeobox 1 b |
|
| chr2_+_47623202 Show fit | 1.93 |
ENSDART00000154465
|
si:ch211-165b10.3 |
|
| chr3_-_32818607 Show fit | 1.67 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr8_-_16697912 Show fit | 1.65 |
ENSDART00000076542
|
retinal pigment epithelium-specific protein 65b |
|
| chr15_+_4632782 Show fit | 1.64 |
ENSDART00000156012
|
si:dkey-35i13.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pdx1_pbx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.8 | GO:0060537 | muscle tissue development(GO:0060537) |
| 0.3 | 5.5 | GO:0072554 | endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554) |
| 0.0 | 3.5 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.5 | 2.2 | GO:1901825 | tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827) |
| 0.1 | 2.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 1.9 | GO:0060037 | pharyngeal system development(GO:0060037) |
| 0.4 | 1.8 | GO:0006522 | alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130) |
| 0.0 | 1.6 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.0 | 1.6 | GO:0031103 | axon regeneration(GO:0031103) |
| 0.5 | 1.5 | GO:0006600 | creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 2.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 1.8 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 1.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 1.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.2 | GO:0046930 | pore complex(GO:0046930) |
| 0.2 | 1.1 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.5 | 2.2 | GO:0050251 | retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885) |
| 0.4 | 1.8 | GO:0003884 | D-amino-acid oxidase activity(GO:0003884) |
| 0.5 | 1.6 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 1.6 | GO:0036122 | BMP binding(GO:0036122) |
| 0.1 | 1.6 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.1 | 1.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.1 | 1.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 1.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.5 | 1.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 1.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 0.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 0.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |