ISMARA results: pbx1a+pbx1b+pbx2+pbx3a+pbx3b

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PRJNA195909:zebrafish embryo and larva development

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Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 3.24

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Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Gene Symbol	Gene ID	Gene Info
pbx3b NCBI UniProt	ENSDARG00000013615	pre-B-cell leukemia homeobox 3b
pbx2 NCBI UniProt	ENSDARG00000019717	pre-B-cell leukemia homeobox 2
pbx3a NCBI UniProt	ENSDARG00000089262	pre-B-cell leukemia homeobox 3a
pbx1a NCBI UniProt	ENSDARG00000100494	pre-B-cell leukemia homeobox 1a
pbx1b NCBI UniProt	ENSDARG00000101131	pre-B-cell leukemia homeobox 1b
pbx3b NCBI UniProt	ENSDARG00000110194	pre-B-cell leukemia homeobox 3b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pbx1a	dr11_v1_chr2_-_18830722_18830783	0.96	4.9e-05	Click!
pbx2	dr11_v1_chr16_+_48616220_48616297	-0.93	3.5e-04	Click!
pbx3b	dr11_v1_chr8_-_34052019_34052019	0.78	1.3e-02	Click!
pbx3a	dr11_v1_chr5_-_5326010_5326010	0.71	3.3e-02	Click!
pbx1b	dr11_v1_chr6_+_2271559_2271559	0.12	7.7e-01	Click!

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_22232902 Show fit	7.70	ENSDART00000101845	crygm2d5 NCBI UniProt Show fit	crystallin, gamma M2d5
chr9_-_22135576 Show fit	5.33	ENSDART00000101902	crygm2d8 NCBI UniProt Show fit	crystallin, gamma M2d8
chr3_+_32526263 Show fit	4.54	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr12_+_15008582 Show fit	4.25	ENSDART00000003847	mylpfb NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle b
chr9_-_22205682 Show fit	4.15	ENSDART00000101869	crygm2d12 NCBI UniProt Show fit	crystallin, gamma M2d12
chr9_-_22240052 Show fit	4.02	ENSDART00000111109	crygm2d9 NCBI UniProt Show fit	crystallin, gamma M2d9
chr9_-_22318511 Show fit	3.93	ENSDART00000129295	crygm2d2 NCBI UniProt Show fit	crystallin, gamma M2d2
chr9_-_22099536 Show fit	3.82	ENSDART00000101923	CR391987.1 NCBI UniProt Show fit
chr9_-_22076368 Show fit	3.60	ENSDART00000128486	crygm2a NCBI UniProt Show fit	crystallin, gamma M2a
chr9_-_22135420 Show fit	3.53	ENSDART00000184959	crygm2d8 NCBI UniProt Show fit	crystallin, gamma M2d8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	62.2	GO:0002088	lens development in camera-type eye(GO:0002088)
0.0	6.3	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.2	5.1	GO:0030032	lamellipodium assembly(GO:0030032)
0.4	4.9	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.3	4.4	GO:0072554	endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.2	4.2	GO:0015671	oxygen transport(GO:0015671)
0.0	4.0	GO:0006813	potassium ion transport(GO:0006813)
0.1	3.8	GO:0019835	cytolysis(GO:0019835)
0.0	3.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	3.7	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)

Showing 1 to 10 of 168 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	GO:0030018	Z disc(GO:0030018)
0.0	4.3	GO:0005911	cell-cell junction(GO:0005911)
0.3	4.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	3.9	GO:0005667	transcription factor complex(GO:0005667)
0.1	3.8	GO:0031225	anchored component of membrane(GO:0031225)
0.6	3.6	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3	3.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	3.0	GO:0042383	sarcolemma(GO:0042383)
0.2	2.9	GO:1990246	uniplex complex(GO:1990246)
0.1	2.9	GO:0071565	nBAF complex(GO:0071565)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	62.9	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	33.8	GO:0001159	core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	21.4	GO:0005509	calcium ion binding(GO:0005509)
0.1	11.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	4.0	GO:0008201	heparin binding(GO:0008201)
0.2	3.9	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	3.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	3.4	GO:0005179	hormone activity(GO:0005179)
0.0	3.2	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.3	3.0	GO:0031720	haptoglobin binding(GO:0031720)

Showing 1 to 10 of 122 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	3.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	2.9	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	2.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	2.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	1.3	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	1.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.1	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	3.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	3.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	2.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	2.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	2.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	2.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	1.8	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	1.6	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling

Showing 1 to 10 of 35 entries

Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 3.24

Motif logo

Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Activity-expression correlation:

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: