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PRJNA195909:zebrafish embryo and larva development

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Results for pax8

Z-value: 1.36

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Transcription factors associated with pax8

Gene Symbol Gene ID Gene Info
pax8
ENSDARG00000015879 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax8dr11_v1_chr5_-_72415578_724155780.835.7e-03Click!

Activity profile of pax8 motif

Sorted Z-values of pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_23487051 5.45 ENSDART00000145496
icn2
ictacalcin 2
chr4_+_25630555 2.21 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr9_+_23665777 1.94 ENSDART00000060905
gypc
glycophorin C (Gerbich blood group)
chr5_+_23630384 1.82 ENSDART00000013745
cx39.9
connexin 39.9
chr7_+_10610791 1.59 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr23_+_43255328 1.45 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr1_-_30457062 1.40 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr6_-_47840465 1.35 ENSDART00000141986
lrig2
leucine-rich repeats and immunoglobulin-like domains 2
chr9_+_39027123 1.30 ENSDART00000004742
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr23_+_26733232 1.29 ENSDART00000035080
zgc:158263
zgc:158263
chr21_-_22928214 1.23 ENSDART00000182760
dub
duboraya
chr9_+_39027312 1.14 ENSDART00000192258
ENSDART00000164407
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr25_-_17579701 1.10 ENSDART00000073684
mmp15a
matrix metallopeptidase 15a
chr7_+_19374683 1.09 ENSDART00000162700
snrpf
small nuclear ribonucleoprotein polypeptide F
chr15_-_34892664 1.08 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr5_-_68826177 1.08 ENSDART00000136605
si:ch211-283h6.4
si:ch211-283h6.4
chr25_-_7520937 1.05 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr14_+_48062180 0.99 ENSDART00000056713
ppid
peptidylprolyl isomerase D
chr20_-_9436521 0.97 ENSDART00000133000
zgc:101840
zgc:101840
chr22_-_25033105 0.86 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr9_+_17348745 0.83 ENSDART00000147488
slain1a
SLAIN motif family, member 1a
chr6_-_130849 0.74 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr1_+_51721851 0.73 ENSDART00000040397
prdx2
peroxiredoxin 2
chr10_+_2715548 0.72 ENSDART00000130793
grk5
G protein-coupled receptor kinase 5
chr23_+_42813415 0.72 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr24_-_36727922 0.71 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr15_+_16387088 0.69 ENSDART00000101789
flot2b
flotillin 2b
chr15_+_638457 0.67 ENSDART00000157162
znf1013
zinc finger protein 1013
chr6_+_25215944 0.65 ENSDART00000165456
si:ch73-97h19.2
si:ch73-97h19.2
chr7_+_20019125 0.61 ENSDART00000186391
bcl6b
B-cell CLL/lymphoma 6, member B
chr6_+_168962 0.61 ENSDART00000182631
CABZ01066694.1

chr16_+_43347966 0.56 ENSDART00000171308
zmp:0000000930
zmp:0000000930
chr2_-_985417 0.55 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr3_+_46444625 0.53 ENSDART00000108686
si:ch211-66e2.3
si:ch211-66e2.3
chr25_+_10834903 0.53 ENSDART00000155247
si:ch211-147g22.5
si:ch211-147g22.5
chr19_+_46372115 0.53 ENSDART00000163935
med30
mediator complex subunit 30
chr25_+_13620555 0.51 ENSDART00000163642
si:ch211-172l8.4
si:ch211-172l8.4
chr20_+_32224405 0.49 ENSDART00000062993
ENSDART00000147448
sesn1
sestrin 1
chr20_+_10498986 0.49 ENSDART00000064114
zgc:100997
zgc:100997
chr14_-_29906209 0.49 ENSDART00000192952
sorbs2b
sorbin and SH3 domain containing 2b
chr11_-_165288 0.45 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr6_-_436658 0.44 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr24_-_35699595 0.43 ENSDART00000167990
mapre2
microtubule-associated protein, RP/EB family, member 2
chr22_-_4813345 0.42 ENSDART00000190650
CU570881.2

chr10_+_36037977 0.40 ENSDART00000164678
katnal1
katanin p60 subunit A-like 1
chr11_-_37693019 0.40 ENSDART00000102898
zgc:158258
zgc:158258
chr23_+_32039386 0.39 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr7_-_28549361 0.38 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr20_+_10498704 0.35 ENSDART00000192985
zgc:100997
zgc:100997
chr16_+_46695777 0.35 ENSDART00000169767
rab25b
RAB25, member RAS oncogene family b
chr14_-_32491127 0.34 ENSDART00000186724
mcf2a
MCF.2 cell line derived transforming sequence a
chr4_-_17803784 0.34 ENSDART00000187195
spi2
Spi-2 proto-oncogene
chr5_+_4298636 0.34 ENSDART00000100061
prdx4
peroxiredoxin 4
chr9_+_43797902 0.30 ENSDART00000020550
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr20_+_34605044 0.30 ENSDART00000153376
si:ch211-242b18.1
si:ch211-242b18.1
chr2_-_5942355 0.29 ENSDART00000110469
tmem125b
transmembrane protein 125b
chr16_+_41135018 0.29 ENSDART00000139435
si:ch211-53m15.2
si:ch211-53m15.2
chr6_-_131401 0.29 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr3_+_46444999 0.28 ENSDART00000186530
si:ch211-66e2.3
si:ch211-66e2.3
chr23_+_7505943 0.28 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr10_+_43039947 0.27 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr17_-_33405301 0.27 ENSDART00000157089
BX323819.1

chr5_-_35888499 0.26 ENSDART00000193932
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr7_+_2797795 0.26 ENSDART00000161208
si:ch211-217i17.1
si:ch211-217i17.1
chr2_+_45552901 0.26 ENSDART00000131701
fndc7a
fibronectin type III domain containing 7a
chr4_+_36489448 0.24 ENSDART00000143181
znf1149
zinc finger protein 1149
chr1_+_55239710 0.24 ENSDART00000174846
si:ch211-286b5.2
si:ch211-286b5.2
chr16_-_31435020 0.24 ENSDART00000138508
zgc:194210
zgc:194210
chr22_+_5959984 0.23 ENSDART00000179378
ENSDART00000178985
ENSDART00000174635
BX322587.2

chr25_-_3139805 0.22 ENSDART00000166625
epx
eosinophil peroxidase
chr16_+_49601838 0.22 ENSDART00000168570
ENSDART00000159236
si:dkey-82o10.4
si:dkey-82o10.4
chr10_+_25726694 0.20 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr20_+_36234335 0.20 ENSDART00000193484
ENSDART00000181664
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr20_+_15164482 0.18 ENSDART00000181842
ENSDART00000063877
prdx6
peroxiredoxin 6
chr5_-_12701603 0.17 ENSDART00000091124
aifm3
apoptosis-inducing factor, mitochondrion-associated, 3
chr23_+_44049509 0.17 ENSDART00000102003
txk
TXK tyrosine kinase
chr9_-_21825913 0.16 ENSDART00000101986
mrpl30
mitochondrial ribosomal protein L30
chr7_-_52388090 0.16 ENSDART00000174104
wdr93
WD repeat domain 93
chr1_+_9966384 0.15 ENSDART00000132607
si:dkeyp-75b4.8
si:dkeyp-75b4.8
chr10_-_24659822 0.15 ENSDART00000171842
ENSDART00000163102
proser1
proline and serine rich 1
chr21_-_2162850 0.14 ENSDART00000159731
gb:ai877918
expressed sequence AI877918
chr4_-_39265279 0.13 ENSDART00000164912
si:ch73-236c18.2
si:ch73-236c18.2
chr7_+_3444473 0.13 ENSDART00000122334
si:ch211-285c6.2
si:ch211-285c6.2
chr25_+_37285737 0.11 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr3_-_16110100 0.10 ENSDART00000051807
lasp1
LIM and SH3 protein 1
chr15_+_15314189 0.10 ENSDART00000156830
camkk1b
calcium/calmodulin-dependent protein kinase kinase 1, alpha b
chr12_+_4900981 0.10 ENSDART00000171507
cd79b
CD79b molecule, immunoglobulin-associated beta
chr23_+_6141541 0.09 ENSDART00000105257
zmp:0000001139
zmp:0000001139
chr14_+_41490262 0.08 ENSDART00000039985
chrnb2l
cholinergic receptor, nicotinic, beta 2, like
chr14_-_1313480 0.05 ENSDART00000097748
il21
interleukin 21
chr7_-_73843720 0.04 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr12_-_13556536 0.04 ENSDART00000166396
CR354395.1

chr21_-_45891262 0.02 ENSDART00000169816
galnt10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr3_-_16110351 0.02 ENSDART00000064838
lasp1
LIM and SH3 protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0097272 ammonia homeostasis(GO:0097272)
0.4 1.2 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.3 1.6 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 1.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.6 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.7 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 0.5 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 1.5 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.2 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.7 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.0 1.1 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 5.4 GO:0021782 glial cell development(GO:0021782)
0.0 0.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.3 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 1.1 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.1 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.4 1.3 GO:0001729 ceramide kinase activity(GO:0001729)
0.3 1.6 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 5.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 1.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.2 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 1.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 4.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL