ISMARA results: pax7a+pax7b+prop1

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PRJNA195909:zebrafish embryo and larva development

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Results for pax7a+pax7b+prop1

Z-value: 1.25

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Transcription factors associated with pax7a+pax7b+prop1

Gene Symbol	Gene ID	Gene Info
prop1 NCBI UniProt	ENSDARG00000039756	PROP paired-like homeobox 1
pax7b NCBI UniProt	ENSDARG00000070818	paired box 7b
pax7a NCBI UniProt	ENSDARG00000100398	paired box 7a
prop1 NCBI UniProt	ENSDARG00000109950	PROP paired-like homeobox 1
pax7a NCBI UniProt	ENSDARG00000111233	paired box 7a
prop1 NCBI UniProt	ENSDARG00000114449	PROP paired-like homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pax7b	dr11_v1_chr23_+_20863145_20863145	-0.90	1.0e-03	Click!
pax7a	dr11_v1_chr11_+_41242644_41242644	-0.82	6.8e-03	Click!
prop1	dr11_v1_chr13_+_8677166_8677304	-0.75	2.0e-02	Click!

Activity profile of pax7a+pax7b+prop1 motif

Sorted Z-values of pax7a+pax7b+prop1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_34916208 Show fit	3.43	ENSDART00000187371	ccna1 NCBI UniProt Show fit	cyclin A1
chr10_-_34002185 Show fit	2.03	ENSDART00000046599	zar1l NCBI UniProt Show fit	zygote arrest 1-like
chr2_+_6253246 Show fit	1.93	ENSDART00000058256 ENSDART00000076700	zp3b NCBI UniProt Show fit	zona pellucida glycoprotein 3b
chr8_+_45334255 Show fit	1.72	ENSDART00000126848 ENSDART00000134161 ENSDART00000142322 ENSDART00000145011 ENSDART00000183560	pabpc1l NCBI UniProt Show fit	poly(A) binding protein, cytoplasmic 1-like
chr16_+_47207691 Show fit	1.60	ENSDART00000062507	ica1 NCBI UniProt Show fit	islet cell autoantigen 1
chr17_-_4245902 Show fit	1.60	ENSDART00000151851	gdf3 NCBI UniProt Show fit	growth differentiation factor 3
chr22_-_20695237 Show fit	1.54	ENSDART00000112722	org NCBI UniProt Show fit	oogenesis-related gene
chr9_+_8390737 Show fit	1.47	ENSDART00000190891 ENSDART00000176877 ENSDART00000144851 ENSDART00000133880 ENSDART00000142233	zgc:113984 NCBI UniProt Show fit	zgc:113984
chr10_+_33393829 Show fit	1.47	ENSDART00000163458 ENSDART00000115379	zgc:153345 NCBI UniProt Show fit	zgc:153345
chr7_+_24573721 Show fit	1.47	ENSDART00000173938 ENSDART00000173681	si:dkeyp-75h12.7 NCBI UniProt Show fit	si:dkeyp-75h12.7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pax7a+pax7b+prop1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0	3.1	GO:0006486	protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1	1.9	GO:2000344	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.3	1.7	GO:1900145	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.2	1.7	GO:0071539	protein localization to centrosome(GO:0071539)
0.1	1.7	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.1	1.6	GO:0050796	regulation of insulin secretion(GO:0050796)
0.0	1.6	GO:0001878	response to yeast(GO:0001878)
0.3	1.5	GO:0000741	karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.3	1.4	GO:0055071	manganese ion homeostasis(GO:0055071)

Showing 1 to 10 of 136 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.4	GO:0097124	cyclin A2-CDK2 complex(GO:0097124)
0.1	2.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	2.0	GO:0016592	mediator complex(GO:0016592)
0.0	1.9	GO:0000786	nucleosome(GO:0000786)
0.1	1.6	GO:0030014	CCR4-NOT complex(GO:0030014)
0.1	1.6	GO:0030667	secretory granule membrane(GO:0030667)
0.1	1.4	GO:0034361	very-low-density lipoprotein particle(GO:0034361)
0.0	1.3	GO:0043186	P granule(GO:0043186)
0.1	1.0	GO:0005674	transcription factor TFIIF complex(GO:0005674)
0.1	1.0	GO:0048188	Set1C/COMPASS complex(GO:0048188)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	3.4	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4	3.0	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0	2.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	2.4	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	2.0	GO:0004896	cytokine receptor activity(GO:0004896)
0.2	1.9	GO:0035804	structural constituent of egg coat(GO:0035804)
0.1	1.7	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	1.6	GO:0004527	exonuclease activity(GO:0004527)
0.0	1.6	GO:0042803	protein homodimerization activity(GO:0042803)

Showing 1 to 10 of 106 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	2.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	1.4	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.3	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	1.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	1.6	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	1.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	1.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	1.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.1	1.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	1.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	1.1	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.0	0.8	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 38 entries

Results for pax7a+pax7b+prop1

Z-value: 1.25

Motif logo

Transcription factors associated with pax7a+pax7b+prop1

Activity-expression correlation:

Activity profile of pax7a+pax7b+prop1 motif

Sorted Z-values of pax7a+pax7b+prop1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pax7a+pax7b+prop1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: