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PRJNA195909:zebrafish embryo and larva development
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Results for pax2a+pax5
Z-value: 1.91
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Transcription factors associated with pax2a+pax5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax2a | dr11_v1_chr13_+_29771463_29771463 | 0.89 | 1.4e-03 | Click! |
| pax5 | dr11_v1_chr1_+_21731382_21731382 | 0.56 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_12031958 Show fit | 4.40 |
ENSDART00000044154
|
troponin T2c, cardiac |
|
| chr7_+_29952169 Show fit | 3.83 |
ENSDART00000173540
ENSDART00000173940 ENSDART00000173906 ENSDART00000173772 ENSDART00000173506 ENSDART00000039657 |
alpha-tropomyosin |
|
| chr7_+_29951997 Show fit | 3.35 |
ENSDART00000173453
|
alpha-tropomyosin |
|
| chr24_-_40731305 Show fit | 3.11 |
ENSDART00000172073
|
|
|
| chr15_+_32711663 Show fit | 3.04 |
ENSDART00000157854
ENSDART00000167515 |
periostin, osteoblast specific factor b |
|
| chr7_+_29952719 Show fit | 2.96 |
ENSDART00000173737
|
alpha-tropomyosin |
|
| chr3_-_55139127 Show fit | 2.89 |
ENSDART00000115324
|
hemoglobin, alpha embryonic 1.3 |
|
| chr3_-_55147731 Show fit | 2.58 |
ENSDART00000155871
ENSDART00000109016 ENSDART00000122904 |
hemoglobin alpha embryonic-3 |
|
| chr3_-_55121125 Show fit | 2.44 |
ENSDART00000125092
|
hemoglobin, alpha embryonic 1 |
|
| chr24_-_40668208 Show fit | 2.32 |
ENSDART00000171543
|
slow myosin heavy chain 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2a+pax5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.1 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 6.6 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.2 | 5.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 4.8 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.2 | 4.4 | GO:0016203 | muscle attachment(GO:0016203) |
| 0.0 | 3.9 | GO:0050767 | regulation of neurogenesis(GO:0050767) |
| 0.0 | 2.9 | GO:0055113 | epiboly involved in gastrulation with mouth forming second(GO:0055113) |
| 0.0 | 2.9 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.8 | 2.3 | GO:0097435 | fibril organization(GO:0097435) |
| 0.3 | 2.3 | GO:0014721 | voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721) slow-twitch skeletal muscle fiber contraction(GO:0031444) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 12.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 8.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 8.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 6.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.4 | 5.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 3.5 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.2 | 3.2 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 3.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.7 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 9.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 6.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.5 | 6.0 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.4 | 5.0 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.1 | 4.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 3.0 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 2.1 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 1.9 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.0 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 0.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 2.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 1.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 1.6 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 1.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.0 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 1.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |