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PRJNA195909:zebrafish embryo and larva development
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Results for patz1
Z-value: 2.58
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Transcription factors associated with patz1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| patz1 | dr11_v1_chr6_+_40952031_40952031 | -0.93 | 2.9e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_5254699 Show fit | 8.88 |
ENSDART00000081951
|
syntaxin 1B |
|
| chr2_+_26179096 Show fit | 5.99 |
ENSDART00000024662
|
phospholipid phosphatase related 3a |
|
| chr19_+_48111285 Show fit | 5.64 |
ENSDART00000169420
|
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 |
|
| chr21_+_26697536 Show fit | 5.26 |
ENSDART00000004109
|
guanine nucleotide binding protein (G protein), gamma 3 |
|
| chr9_-_44295071 Show fit | 5.07 |
ENSDART00000011837
|
neuronal differentiation 1 |
|
| chr12_-_16941319 Show fit | 5.02 |
ENSDART00000109968
|
zgc:174855 |
|
| chr16_-_42390441 Show fit | 5.00 |
ENSDART00000148475
|
chondroitin sulfate proteoglycan 5a |
|
| chr21_-_28901095 Show fit | 4.64 |
ENSDART00000180820
|
CXXC finger protein 5a |
|
| chr13_+_12045758 Show fit | 4.57 |
ENSDART00000079398
ENSDART00000165467 ENSDART00000165880 |
guanine nucleotide binding protein (G protein), gamma 2 |
|
| chr12_-_26851726 Show fit | 4.55 |
ENSDART00000047724
|
zinc finger E-box binding homeobox 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of patz1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.1 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 1.8 | 8.9 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.2 | 8.2 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway(GO:0048010) |
| 0.2 | 6.9 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.4 | 6.0 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 1.9 | 5.8 | GO:0006601 | creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601) |
| 0.2 | 5.3 | GO:0007634 | optokinetic behavior(GO:0007634) |
| 0.1 | 5.2 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.9 | 4.6 | GO:0070587 | regulation of cell-cell adhesion involved in gastrulation(GO:0070587) |
| 0.3 | 4.4 | GO:0048923 | posterior lateral line neuromast hair cell differentiation(GO:0048923) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 21.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.7 | 12.4 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.4 | 8.9 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.5 | 5.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 5.2 | GO:0005576 | extracellular region(GO:0005576) |
| 0.5 | 5.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 4.8 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.2 | 4.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 4.3 | GO:0005605 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 8.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 8.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 7.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 6.7 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.3 | 6.7 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.2 | 6.0 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 5.8 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.3 | 5.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.4 | 5.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 7.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 5.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.2 | 4.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.4 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.5 | 8.9 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 6.9 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 4.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 3.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |