ISMARA results: otx2b

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PRJNA195909:zebrafish embryo and larva development

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Results for otx2b

Z-value: 2.20

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Transcription factors associated with otx2b

Gene Symbol	Gene ID	Gene Info
otx2b NCBI UniProt	ENSDARG00000011235	orthodenticle homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
otx2b	dr11_v1_chr17_-_44249720_44249720	0.78	1.3e-02	Click!

Activity profile of otx2b motif

Sorted Z-values of otx2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_26144765 Show fit	10.88	ENSDART00000146267 ENSDART00000043932	atp2a1 NCBI UniProt Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr15_+_32727848 Show fit	5.32	ENSDART00000161361	postnb NCBI UniProt Show fit	periostin, osteoblast specific factor b
chr5_-_28625515 Show fit	4.26	ENSDART00000190782 ENSDART00000179736 ENSDART00000131729	tnc NCBI UniProt Show fit	tenascin C
chr23_+_36063599 Show fit	3.74	ENSDART00000103147	hoxc12a NCBI UniProt Show fit	homeobox C12a
chr14_-_4273396 Show fit	3.54	ENSDART00000127318	frmpd1b NCBI UniProt Show fit	FERM and PDZ domain containing 1b
chr8_-_54077740 Show fit	3.45	ENSDART00000027000	rho NCBI UniProt Show fit	rhodopsin
chr22_+_5103349 Show fit	3.42	ENSDART00000083474	atcaya NCBI UniProt Show fit	ataxia, cerebellar, Cayman type a
chr14_+_46313135 Show fit	3.41	ENSDART00000172902	cryba1l1 NCBI UniProt Show fit	crystallin, beta A1, like 1
chr7_-_13882988 Show fit	3.34	ENSDART00000169828	rlbp1a NCBI UniProt Show fit	retinaldehyde binding protein 1a
chr14_-_36378494 Show fit	3.33	ENSDART00000058503	gpm6aa NCBI UniProt Show fit	glycoprotein M6Aa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of otx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	10.9	GO:0031446	regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.5	8.6	GO:0016203	muscle attachment(GO:0016203)
2.3	6.9	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.0	5.1	GO:0009952	anterior/posterior pattern specification(GO:0009952)
0.5	4.6	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	3.5	GO:0060041	retina development in camera-type eye(GO:0060041)
1.1	3.4	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.3	3.4	GO:0006798	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1	3.2	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.3	3.1	GO:0006833	water transport(GO:0006833)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	10.9	GO:0031673	H zone(GO:0031673)
0.0	8.9	GO:0031012	extracellular matrix(GO:0031012)
0.2	5.1	GO:0060170	ciliary membrane(GO:0060170)
0.3	4.6	GO:0071564	npBAF complex(GO:0071564)
0.1	4.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	3.5	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	3.3	GO:0044295	axonal growth cone(GO:0044295)
0.1	3.2	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	2.2	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3	1.7	GO:0034359	mature chylomicron(GO:0034359)

Showing 1 to 10 of 25 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	10.9	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	6.7	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	5.4	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	4.0	GO:0003735	structural constituent of ribosome(GO:0003735)
1.3	3.9	GO:0005502	11-cis retinal binding(GO:0005502)
0.3	3.4	GO:0004309	exopolyphosphatase activity(GO:0004309)
0.5	3.3	GO:0034632	retinol transporter activity(GO:0034632)
0.0	3.3	GO:1902936	phosphatidylinositol bisphosphate binding(GO:1902936)
0.0	3.2	GO:0016779	nucleotidyltransferase activity(GO:0016779)
0.3	3.1	GO:0015250	water channel activity(GO:0015250)

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	6.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	4.4	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	2.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	2.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.7	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	10.9	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	4.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.7	4.3	REACTOME OPSINS	Genes involved in Opsins
0.0	4.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	1.0	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.6	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL

Showing 1 to 10 of 13 entries

Results for otx2b

Z-value: 2.20

Motif logo

Transcription factors associated with otx2b

Activity-expression correlation:

Activity profile of otx2b motif

Sorted Z-values of otx2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of otx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: