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PRJNA195909:zebrafish embryo and larva development
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Results for onecut1+onecutl
Z-value: 2.38
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Transcription factors associated with onecut1+onecutl
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| onecutl | dr11_v1_chr16_-_29528198_29528198 | 0.79 | 1.1e-02 | Click! |
| onecut1 | dr11_v1_chr18_+_38755023_38755024 | 0.42 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_61205711 Show fit | 6.46 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr23_-_31372639 Show fit | 3.55 |
ENSDART00000179908
ENSDART00000135620 ENSDART00000053367 |
high mobility group nucleosomal binding domain 3 |
|
| chr21_-_41305748 Show fit | 3.36 |
ENSDART00000170457
|
neuronal vesicle trafficking associated 2 |
|
| chr11_+_7158723 Show fit | 3.23 |
ENSDART00000035560
|
transmembrane protein 38A |
|
| chr10_+_9553935 Show fit | 3.20 |
ENSDART00000028855
|
si:ch211-243g18.2 |
|
| chr15_+_28202170 Show fit | 3.13 |
ENSDART00000077736
|
vitronectin a |
|
| chr1_-_10071422 Show fit | 3.11 |
ENSDART00000135522
ENSDART00000033118 |
fibrinogen alpha chain |
|
| chr3_-_41791178 Show fit | 3.06 |
ENSDART00000049687
|
galectin-related inter-fiber protein |
|
| chr14_-_25985698 Show fit | 3.00 |
ENSDART00000172909
ENSDART00000123053 |
antioxidant 1 copper chaperone |
|
| chr19_-_21766461 Show fit | 2.99 |
ENSDART00000104279
|
zinc finger protein 516 |
Network of associatons between targets according to the STRING database.
First level regulatory network of onecut1+onecutl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 0.1 | 5.7 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 4.0 | GO:0018393 | internal protein amino acid acetylation(GO:0006475) internal peptidyl-lysine acetylation(GO:0018393) |
| 0.0 | 4.0 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 1.2 | 3.5 | GO:0061178 | insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 3.3 | GO:0019835 | cytolysis(GO:0019835) |
| 0.2 | 3.1 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.1 | 3.1 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.4 | 3.0 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 1.0 | 2.9 | GO:0030043 | actin filament fragmentation(GO:0030043) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 4.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 3.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 3.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 3.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.0 | 3.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 2.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 2.7 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.6 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 3.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 3.4 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 3.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.0 | 3.1 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.1 | 3.1 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.6 | 3.0 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 3.0 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 2.9 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 2.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 2.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.2 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.3 | 3.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 3.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 2.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 2.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.9 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.0 | 1.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |