ISMARA results: olig3_olig2+olig4

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PRJNA195909:zebrafish embryo and larva development

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Results for olig3_olig2+olig4_olig1

Z-value: 1.37

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Transcription factors associated with olig3_olig2+olig4_olig1

Gene Symbol	Gene ID	Gene Info
olig3 NCBI UniProt	ENSDARG00000074253	oligodendrocyte transcription factor 3
olig2 NCBI UniProt	ENSDARG00000040946	oligodendrocyte lineage transcription factor 2
olig4 NCBI UniProt	ENSDARG00000052610	oligodendrocyte transcription factor 4
olig4 NCBI UniProt	ENSDARG00000116678	oligodendrocyte transcription factor 4
olig1 NCBI UniProt	ENSDARG00000040948	oligodendrocyte transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
olig2	dr11_v1_chr9_-_32753535_32753535	-0.93	3.4e-04	Click!
olig4	dr11_v1_chr13_+_45967179_45967179	-0.86	3.2e-03	Click!
olig1	dr11_v1_chr9_-_32730487_32730487	-0.46	2.1e-01	Click!

Activity profile of olig3_olig2+olig4_olig1 motif

Sorted Z-values of olig3_olig2+olig4_olig1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_39036604 Show fit	2.80	ENSDART00000129963	rbp1 NCBI UniProt Show fit	retinol binding protein 1b, cellular
chr20_-_1265562 Show fit	2.54	ENSDART00000189866	lats1 NCBI UniProt Show fit	large tumor suppressor kinase 1
chr8_-_51507144 Show fit	2.28	ENSDART00000024882 ENSDART00000135166	fgfr1a NCBI UniProt Show fit	fibroblast growth factor receptor 1a
chr18_-_40708537 Show fit	2.11	ENSDART00000077577	si:ch211-132b12.8 NCBI UniProt Show fit	si:ch211-132b12.8
chr7_+_46020508 Show fit	1.98	ENSDART00000170294	ccne1 NCBI UniProt Show fit	cyclin E1
chr5_-_27994679 Show fit	1.86	ENSDART00000132740	ppp3cca NCBI UniProt Show fit	protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr12_-_17863467 Show fit	1.64	ENSDART00000042006	baiap2l1a NCBI UniProt Show fit	BAI1-associated protein 2-like 1a
chr19_-_8798178 Show fit	1.62	ENSDART00000188232	cers2a NCBI UniProt Show fit	ceramide synthase 2a
chr13_+_15581270 Show fit	1.54	ENSDART00000189880 ENSDART00000190067 ENSDART00000041293	mark3a NCBI UniProt Show fit	MAP/microtubule affinity-regulating kinase 3a
chr10_-_32465462 Show fit	1.52	ENSDART00000134056	uvrag NCBI UniProt Show fit	UV radiation resistance associated gene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of olig3_olig2+olig4_olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.8	GO:0046620	secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.4	2.6	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	2.4	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0	2.4	GO:0016579	protein deubiquitination(GO:0016579)
0.8	2.3	GO:0010863	positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.1	2.3	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.0	2.3	GO:1901800	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.6	2.2	GO:0038093	Fc receptor signaling pathway(GO:0038093)
0.0	2.2	GO:0030050	vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.2	2.1	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)

Showing 1 to 10 of 239 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0000323	lytic vacuole(GO:0000323)
0.7	2.8	GO:0097134	cyclin E1-CDK2 complex(GO:0097134)
0.1	2.6	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	2.6	GO:0016459	myosin complex(GO:0016459)
0.0	2.1	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	1.9	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.9	GO:0005921	gap junction(GO:0005921)
0.1	1.9	GO:0043596	nuclear replication fork(GO:0043596)
0.3	1.7	GO:0005899	insulin receptor complex(GO:0005899)
0.1	1.7	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)

Showing 1 to 10 of 108 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.0	2.8	GO:0008094	DNA-dependent ATPase activity(GO:0008094)
0.0	2.4	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1	2.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.1	2.3	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	2.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	2.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.2	2.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.2	2.0	GO:0035198	miRNA binding(GO:0035198)
0.3	1.9	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)

Showing 1 to 10 of 155 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	2.8	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	2.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	2.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	1.8	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.7	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.0	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	0.9	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.8	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.0	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.1	2.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	2.7	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	2.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	2.2	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	1.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	1.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	1.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.1	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	1.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 55 entries

Results for olig3_olig2+olig4_olig1

Z-value: 1.37

Motif logo

Transcription factors associated with olig3_olig2+olig4_olig1

Activity-expression correlation:

Activity profile of olig3_olig2+olig4_olig1 motif

Sorted Z-values of olig3_olig2+olig4_olig1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of olig3_olig2+olig4_olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: