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PRJNA195909:zebrafish embryo and larva development
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Results for nrf1
Z-value: 5.08
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Transcription factors associated with nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nrf1 | dr11_v1_chr4_-_15103646_15103696 | 0.71 | 3.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_22320738 Show fit | 6.92 |
ENSDART00000073566
|
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr25_+_22319940 Show fit | 6.11 |
ENSDART00000154065
ENSDART00000153492 ENSDART00000024866 ENSDART00000154376 |
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr13_-_2336584 Show fit | 5.36 |
ENSDART00000113692
|
transcription elongation factor B (SIII), polypeptide 3, like |
|
| chr5_+_62319217 Show fit | 5.32 |
ENSDART00000050879
|
phoenix |
|
| chr15_+_44201056 Show fit | 5.17 |
ENSDART00000162433
ENSDART00000148336 |
|
|
| chr12_-_30359498 Show fit | 5.04 |
ENSDART00000152981
ENSDART00000189988 |
tudor domain containing 1 |
|
| chr24_-_42072886 Show fit | 4.94 |
ENSDART00000171389
|
|
|
| chr12_-_30359031 Show fit | 4.91 |
ENSDART00000192628
|
tudor domain containing 1 |
|
| chr15_-_45538773 Show fit | 4.88 |
ENSDART00000113494
|
Mab-21 domain containing 2 |
|
| chr11_-_6452444 Show fit | 4.78 |
ENSDART00000137879
ENSDART00000134957 ENSDART00000004483 |
La ribonucleoprotein domain family, member 6b |
Network of associatons between targets according to the STRING database.
First level regulatory network of nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 13.0 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.0 | 10.1 | GO:0006396 | RNA processing(GO:0006396) |
| 1.0 | 9.9 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.1 | 8.7 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 8.6 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.1 | 7.4 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 1.4 | 7.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 6.9 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.2 | 6.8 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.4 | 5.9 | GO:1900077 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 11.9 | GO:0005813 | centrosome(GO:0005813) |
| 1.2 | 9.9 | GO:0071546 | pi-body(GO:0071546) |
| 0.1 | 9.8 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.4 | 7.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 7.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 7.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 6.8 | GO:0016604 | nuclear body(GO:0016604) |
| 1.1 | 6.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 6.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0042393 | histone binding(GO:0042393) |
| 4.3 | 13.0 | GO:0016713 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
| 0.0 | 13.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.1 | 12.2 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.1 | 11.7 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.3 | 10.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 10.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 10.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.2 | 9.9 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.0 | 9.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.3 | 5.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 5.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 2.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 2.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 13.0 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 7.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 6.5 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 6.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 1.1 | 5.6 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.6 | 5.6 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 4.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 4.8 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.1 | 4.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |