ISMARA results: nr5a1a+nr5a2+nr5a5

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PRJNA195909:zebrafish embryo and larva development

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Results for nr5a1a+nr5a2+nr5a5

Z-value: 1.71

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Transcription factors associated with nr5a1a+nr5a2+nr5a5

Gene Symbol	Gene ID	Gene Info
nr5a5 NCBI UniProt	ENSDARG00000039116	nuclear receptor subfamily 5, group A, member 5
nr5a2 NCBI UniProt	ENSDARG00000100940	nuclear receptor subfamily 5, group A, member 2
nr5a1a NCBI UniProt	ENSDARG00000103176	nuclear receptor subfamily 5, group A, member 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr5a1a	dr11_v1_chr8_-_52859301_52859301	0.87	2.1e-03	Click!
nr5a2	dr11_v1_chr22_-_22719440_22719440	0.75	1.9e-02	Click!
nr5a5	dr11_v1_chr3_-_53465223_53465249	0.59	9.6e-02	Click!

Activity profile of nr5a1a+nr5a2+nr5a5 motif

Sorted Z-values of nr5a1a+nr5a2+nr5a5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_1970071 Show fit	4.75	ENSDART00000080608	hoxd10a NCBI UniProt Show fit	homeobox D10a
chr19_-_30404096 Show fit	3.80	ENSDART00000103475	agr2 NCBI UniProt Show fit	anterior gradient 2
chr15_-_23645810 Show fit	3.73	ENSDART00000168845	ckmb NCBI UniProt Show fit	creatine kinase, muscle b
chr19_-_30403922 Show fit	3.30	ENSDART00000181841	agr2 NCBI UniProt Show fit	anterior gradient 2
chr6_-_15653494 Show fit	2.50	ENSDART00000038133	trim63a NCBI UniProt Show fit	tripartite motif containing 63a
chr7_+_25913225 Show fit	2.44	ENSDART00000129924	hmgb3a NCBI UniProt Show fit	high mobility group box 3a
chr20_+_10539293 Show fit	2.37	ENSDART00000182265	serpina1l NCBI UniProt Show fit	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr17_-_12385308 Show fit	2.24	ENSDART00000080927	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr22_-_2886937 Show fit	2.15	ENSDART00000063533	aqp12 NCBI UniProt Show fit	aquaporin 12
chr6_+_37894914 Show fit	2.15	ENSDART00000148817	oca2 NCBI UniProt Show fit	oculocutaneous albinism II

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr5a1a+nr5a2+nr5a5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.3	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.7	7.1	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.4	5.2	GO:0006599	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.4	3.1	GO:0034389	lipid particle organization(GO:0034389)
0.1	2.8	GO:0006144	purine nucleobase metabolic process(GO:0006144)
0.1	2.7	GO:0043297	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0	2.6	GO:0002040	sprouting angiogenesis(GO:0002040)
0.1	2.4	GO:0021884	forebrain neuron development(GO:0021884)
0.6	2.3	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.2	2.2	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)

Showing 1 to 10 of 129 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	23.6	GO:0005576	extracellular region(GO:0005576)
0.0	4.3	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.1	3.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	3.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.9	2.8	GO:1902560	GMP reductase complex(GO:1902560)
0.2	2.4	GO:0042627	chylomicron(GO:0042627)
0.4	2.2	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	2.1	GO:0005605	basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1	2.0	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	2.0	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.4	GO:0042803	protein homodimerization activity(GO:0042803)
0.4	5.2	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0	4.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	4.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	4.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	4.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	3.8	GO:0051015	actin filament binding(GO:0051015)
0.0	3.4	GO:0005198	structural molecule activity(GO:0005198)
0.9	2.8	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0	2.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	1.7	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	1.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.7	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	1.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	1.4	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	1.0	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	2.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	2.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	1.8	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	1.5	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	1.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	1.3	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	1.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	1.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins

Showing 1 to 10 of 35 entries

Results for nr5a1a+nr5a2+nr5a5

Z-value: 1.71

Motif logo

Transcription factors associated with nr5a1a+nr5a2+nr5a5

Activity-expression correlation:

Activity profile of nr5a1a+nr5a2+nr5a5 motif

Sorted Z-values of nr5a1a+nr5a2+nr5a5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr5a1a+nr5a2+nr5a5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: