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PRJNA195909:zebrafish embryo and larva development

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Results for nr3c2

Z-value: 0.73

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Transcription factors associated with nr3c2

Gene Symbol Gene ID Gene Info
nr3c2
ENSDARG00000102082 nuclear receptor subfamily 3, group C, member 2
nr3c2
ENSDARG00000115513 nuclear receptor subfamily 3, group C, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr3c2dr11_v1_chr1_-_37087966_37087966-0.422.7e-01Click!

Activity profile of nr3c2 motif

Sorted Z-values of nr3c2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_35445462 1.53 ENSDART00000124497
tdrd6
tudor domain containing 6
chr11_-_43473824 1.53 ENSDART00000179561
tmem63bb
transmembrane protein 63Bb
chr6_+_4255319 1.42 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr18_-_20608025 1.41 ENSDART00000090156
ENSDART00000151980
bcl2l13
BCL2 like 13
chr10_+_33754967 1.39 ENSDART00000153442
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr14_-_46113321 1.28 ENSDART00000169040
ENSDART00000161475
ENSDART00000124925
si:ch211-235e9.8
si:ch211-235e9.8
chr3_-_40051425 1.26 ENSDART00000146700
llgl1
lethal giant larvae homolog 1 (Drosophila)
chr17_-_6613458 1.16 ENSDART00000175024
si:ch211-189e2.3
si:ch211-189e2.3
chr4_+_11723852 1.14 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr18_-_20608300 1.07 ENSDART00000140632
bcl2l13
BCL2 like 13
chr11_+_34522554 1.03 ENSDART00000109833
zmat3
zinc finger, matrin-type 3
chr24_-_23784701 0.95 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr24_-_20641000 0.87 ENSDART00000166135
zbtb47b
zinc finger and BTB domain containing 47b
chr22_-_34979139 0.86 ENSDART00000116455
ENSDART00000133537
arhgap19
Rho GTPase activating protein 19
chr11_+_5880562 0.85 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
dazap1
DAZ associated protein 1
chr24_-_38097305 0.82 ENSDART00000124321
crp2
C-reactive protein 2
chr22_-_16275236 0.76 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr8_+_23034718 0.75 ENSDART00000184512
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr7_-_51749683 0.68 ENSDART00000083190
hdac8
histone deacetylase 8
chr13_-_33700461 0.66 ENSDART00000160520
mad2l1bp
MAD2L1 binding protein
chr11_+_34523132 0.66 ENSDART00000192257
zmat3
zinc finger, matrin-type 3
chr5_-_9540641 0.63 ENSDART00000124384
ENSDART00000160079
gak
cyclin G associated kinase
chr20_+_54336137 0.59 ENSDART00000113792
cipcb
CLOCK-interacting pacemaker b
chr15_+_23951560 0.49 ENSDART00000191133
myo18ab
myosin XVIIIAb
chr1_+_54199406 0.48 ENSDART00000176578
tsc2
TSC complex subunit 2
chr16_+_11188810 0.47 ENSDART00000186011
cicb
capicua transcriptional repressor b
chr15_+_40188076 0.47 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr21_+_6291027 0.46 ENSDART00000180467
ENSDART00000184952
ENSDART00000184006
fnbp1b
formin binding protein 1b
chr25_-_13408760 0.46 ENSDART00000154445
gins3
GINS complex subunit 3
chr9_+_22388686 0.42 ENSDART00000182731
ENSDART00000181462
dgkg
diacylglycerol kinase, gamma
chr5_+_30518441 0.39 ENSDART00000132664
hmbsa
hydroxymethylbilane synthase a
chr8_+_39767915 0.39 ENSDART00000017153
hps4
Hermansky-Pudlak syndrome 4
chr2_-_32512648 0.35 ENSDART00000170674
abcf2a
ATP-binding cassette, sub-family F (GCN20), member 2a
chr2_+_29257942 0.32 ENSDART00000184362
ENSDART00000025562
cdh18a
cadherin 18, type 2a
chr22_-_36519590 0.30 ENSDART00000129318
CABZ01045212.1

chr21_+_6290566 0.28 ENSDART00000161647
fnbp1b
formin binding protein 1b
chr10_+_8554929 0.25 ENSDART00000190849
tbc1d10ab
TBC1 domain family, member 10Ab
chr10_-_24689725 0.24 ENSDART00000079566
si:ch211-287a12.9
si:ch211-287a12.9
chr8_-_45834825 0.22 ENSDART00000132965
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr20_-_39391833 0.21 ENSDART00000135149
si:dkey-217m5.8
si:dkey-217m5.8
chr10_+_20364009 0.18 ENSDART00000186139
ENSDART00000080395
golga7
golgin A7
chr8_-_45835056 0.18 ENSDART00000022242
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr5_-_54792239 0.15 ENSDART00000056213
pik3r1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_28473350 0.11 ENSDART00000190608
ENSDART00000148175
si:ch1073-440b2.1
si:ch1073-440b2.1
chr10_+_29849497 0.08 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr3_-_37476475 0.07 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr16_-_11932923 0.04 ENSDART00000103975
cd4-1
CD4-1 molecule
chr25_+_10416583 0.04 ENSDART00000073907
ehf
ets homologous factor
chr19_+_7916790 0.01 ENSDART00000081584
si:dkey-266f7.1
si:dkey-266f7.1
chr5_+_9382301 0.01 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr15_-_18429550 0.01 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 1.5 GO:0030719 P granule organization(GO:0030719)
0.1 1.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.1 0.6 GO:0072318 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 1.3 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.7 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 1.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.3 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 0.5 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.1 0.4 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 0.7 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.0 0.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.5 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0033391 chromatoid body(GO:0033391)
0.1 0.8 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.4 GO:0031085 BLOC-3 complex(GO:0031085)
0.1 0.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.3 GO:0045159 myosin II binding(GO:0045159)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 1.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.7 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling