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PRJNA195909:zebrafish embryo and larva development

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Results for nr2e3

Z-value: 1.21

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Transcription factors associated with nr2e3

Gene Symbol Gene ID Gene Info
ENSDARG00000045904 nuclear receptor subfamily 2, group E, member 3
ENSDARG00000113178 nuclear receptor subfamily 2, group E, member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2e3dr11_v1_chr25_+_22274642_22274642-0.531.4e-01Click!

Activity profile of nr2e3 motif

Sorted Z-values of nr2e3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_30293224 1.95 ENSDART00000101051
stem-loop binding protein 2
chr12_+_30789611 1.49 ENSDART00000181501
aldehyde dehydrogenase 18 family, member A1
chr19_-_27550768 1.49 ENSDART00000142313
si:dkeyp-46h3.8
chr9_-_8314028 1.37 ENSDART00000102739
si:ch211-145c1.1
chr21_+_15723069 1.32 ENSDART00000149126
ENSDART00000130628
purinergic receptor P2X, ligand-gated ion channel, 4a
chr5_+_57924611 1.16 ENSDART00000050949
B-cell translocation gene 4
chr15_+_38299385 1.15 ENSDART00000142403
si:dkey-24p1.6
chr20_-_44576949 1.12 ENSDART00000148639
UBX domain protein 2A
chr11_-_3494964 1.08 ENSDART00000162369
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b
chr17_+_13031497 1.07 ENSDART00000115208
F-box protein 33
chr21_-_34261677 1.07 ENSDART00000124649
ENSDART00000172381
ENSDART00000064320
ALG13, UDP-N-acetylglucosaminyltransferase subunit
chr6_-_24384654 1.07 ENSDART00000164723
bromodomain, testis-specific
chr19_-_27564458 1.06 ENSDART00000123155
si:dkeyp-46h3.6
chr5_+_37747128 1.04 ENSDART00000148795
D4, zinc and double PHD fingers family 2
chr19_+_8612839 1.00 ENSDART00000144925
sorting nexin family member 27a
chr10_+_2981090 0.97 ENSDART00000111830
zinc finger, FYVE domain containing 16
chr5_+_36768674 0.96 ENSDART00000146854
MAP/microtubule affinity-regulating kinase 4a
chr1_+_16625678 0.94 ENSDART00000164899
pericentriolar material 1
chr19_+_42231431 0.94 ENSDART00000102698
jumping translocation breakpoint
chr15_+_38299563 0.93 ENSDART00000099375
si:dkey-24p1.6
chr4_-_17263210 0.93 ENSDART00000147853
lymphoid-restricted membrane protein
chr19_-_27564980 0.91 ENSDART00000171967
si:dkeyp-46h3.8
chr21_+_4116437 0.90 ENSDART00000167791
ENSDART00000123759
Rap guanine nucleotide exchange factor (GEF) 1b
chr10_+_15255012 0.89 ENSDART00000023766
very low density lipoprotein receptor
chr9_-_34269066 0.88 ENSDART00000059955
immunoglobulin-like domain containing receptor 1b
chr6_-_25163722 0.88 ENSDART00000192225
zinc finger protein 326
chr23_+_2740741 0.88 ENSDART00000134938
zgc:114123
chr6_+_40992883 0.86 ENSDART00000076061
transforming growth factor, alpha
chr14_-_46617228 0.85 ENSDART00000161010
ENSDART00000171054
prominin 1a
chr8_-_1838315 0.85 ENSDART00000114476
ENSDART00000140077
phosphatidylinositol 4-kinase, catalytic, alpha b
chr6_+_37754763 0.85 ENSDART00000110770
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr13_-_6252498 0.85 ENSDART00000115157
tubulin, alpha 4 like
chr24_-_10014512 0.84 ENSDART00000124341
ENSDART00000191630
zgc:171474
chr20_-_20324792 0.84 ENSDART00000042376
small nuclear RNA activating complex, polypeptide 1a
chr2_+_45382433 0.82 ENSDART00000142251
WD repeat domain 47a
chr17_+_5931530 0.82 ENSDART00000168326
ENSDART00000189790
zinc finger protein 513b
chr10_+_15255198 0.82 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr17_-_2596125 0.81 ENSDART00000175740
zona pellucida glycoprotein 3, tandem duplicate 2
chr13_-_35459928 0.81 ENSDART00000144109
SLX4 interacting protein
chr22_-_6562618 0.81 ENSDART00000106100
zgc:171490
chr10_+_16911951 0.80 ENSDART00000164933
unc-13 homolog B
chr22_-_17652914 0.80 ENSDART00000138483
si:ch73-243b8.4
chr23_+_27756984 0.80 ENSDART00000137103
lysine (K)-specific methyltransferase 2D
chr22_-_17652112 0.79 ENSDART00000189205
histocompatibility (minor) HA-1 b
chr24_-_5691956 0.79 ENSDART00000189112
deleted in autism 1b
chr6_+_32338334 0.78 ENSDART00000065149
dedicator of cytokinesis 7
chr2_+_30032303 0.77 ENSDART00000151841
RNA binding motif protein 33b
chr25_+_15994100 0.77 ENSDART00000144723
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr19_+_43684376 0.77 ENSDART00000051723
si:ch211-193k19.1
chr13_-_24877577 0.77 ENSDART00000182705
K(lysine) acetyltransferase 6B
chr5_-_20135679 0.77 ENSDART00000079402
ubiquitin specific peptidase 30
chr5_-_62925282 0.76 ENSDART00000188048
sperm antigen with calponin homology and coiled-coil domains 1
chr18_+_37120096 0.76 ENSDART00000147385
signal-induced proliferation-associated 1 like 3
chr14_+_45028062 0.75 ENSDART00000184717
ENSDART00000185481
ATPase phospholipid transporting 8A1
chr9_+_33216945 0.75 ENSDART00000134029
si:ch211-125e6.12
chr8_+_13364950 0.75 ENSDART00000159760
solute carrier family 5 (sodium/iodide cotransporter), member 5
chr14_+_30328567 0.75 ENSDART00000105889
microtubule associated tumor suppressor 1a
chr3_+_24708685 0.74 ENSDART00000153507
megakaryoblastic leukemia (translocation) 1a
chr24_-_23784701 0.73 ENSDART00000090368
serum/glucocorticoid regulated kinase family, member 3
chr9_+_13641668 0.72 ENSDART00000135877
amyotrophic lateral sclerosis 2a (juvenile)
chr13_+_16522608 0.72 ENSDART00000182838
ENSDART00000143200
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr5_-_15494164 0.71 ENSDART00000140668
ENSDART00000188076
ENSDART00000085943
TAO kinase 3a
chr4_-_77114795 0.71 ENSDART00000144849

chr19_-_5812319 0.71 ENSDART00000114472
si:ch211-264f5.8
chr5_-_32336613 0.71 ENSDART00000139732
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr17_-_6954719 0.71 ENSDART00000188180
zinc finger and BTB domain containing 24
chr6_-_15641686 0.71 ENSDART00000135583
melanophilin a
chr19_+_41479990 0.70 ENSDART00000087187
argonaute RISC catalytic component 2
chr4_-_73411863 0.68 ENSDART00000171434
zgc:162958
chr10_-_35149513 0.67 ENSDART00000063434
ENSDART00000131291
receptor-interacting serine-threonine kinase 4
chr23_+_43684494 0.67 ENSDART00000149878
OTU deubiquitinase 4
chr14_-_21618005 0.66 ENSDART00000043162
receptor accessory protein 2
chr16_-_31598771 0.66 ENSDART00000016386
thyroglobulin
chr17_-_36860265 0.66 ENSDART00000182786
ENSDART00000193967
SUMO1/sentrin specific peptidase 6b
chr22_-_22130623 0.66 ENSDART00000113168

chr23_-_22523303 0.66 ENSDART00000079019
splA/ryanodine receptor domain and SOCS box containing 1
chr20_-_31252809 0.66 ENSDART00000137236
hippocalcin-like 1
chr1_-_12397258 0.66 ENSDART00000144596
sodium channel and clathrin linker 1
chr15_-_33304133 0.65 ENSDART00000186092
neurobeachin b
chr23_+_38957738 0.65 ENSDART00000193480
ATPase phospholipid transporting 9A (putative)
chr23_+_12545114 0.65 ENSDART00000105283
ENSDART00000166990
si:zfos-452g4.1
chr19_+_42660158 0.65 ENSDART00000018328
F-box and leucine-rich repeat protein 2
chr25_+_33033633 0.65 ENSDART00000192336
talin 2b
chr24_+_15020402 0.65 ENSDART00000148102
docking protein 6
chr6_+_10333920 0.64 ENSDART00000151667
ENSDART00000151477
cordon-bleu WH2 repeat protein-like 1a
chr17_-_2578026 0.64 ENSDART00000065821
zona pellucida glycoprotein 3, tandem duplicate 2
chr20_-_32981053 0.64 ENSDART00000138708
neuroblastoma amplified sequence
chr3_+_17456428 0.64 ENSDART00000090676
ENSDART00000182082
si:ch211-210g13.5
chr8_+_29742237 0.64 ENSDART00000133955
ENSDART00000020621
mitogen-activated protein kinase 4
chr12_+_32368574 0.64 ENSDART00000086389
si:ch211-277e21.2
chr15_+_781717 0.63 ENSDART00000154903
zinc finger protein 970
chr20_+_33987465 0.63 ENSDART00000061751
zona pellucida glycoprotein 3a, tandem duplicate 2
chr16_-_17577581 0.63 ENSDART00000186475
ENSDART00000137215
caspase 2, apoptosis-related cysteine peptidase
chr23_+_24272421 0.62 ENSDART00000029974
chloride channel K
chr2_-_38114370 0.62 ENSDART00000131837
chromodomain helicase DNA binding protein 8
chr20_+_33991801 0.62 ENSDART00000061744
zona pellucida glycoprotein 3a, tandem duplicate 1
chr25_-_17587785 0.62 ENSDART00000073679
ENSDART00000146851
zgc:66449
chr25_-_7918526 0.61 ENSDART00000104686
ENSDART00000156761
autophagy/beclin-1 regulator 1b
chr24_+_8904135 0.61 ENSDART00000066782
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr1_+_59314675 0.61 ENSDART00000161872
ENSDART00000160658
ENSDART00000169792
ENSDART00000160735
poly(A)-specific ribonuclease (deadenylation nuclease)
chr15_+_14378829 0.60 ENSDART00000160145
si:ch211-11n16.2
chr6_-_53885514 0.60 ENSDART00000173812
ENSDART00000127144
calcium channel, voltage-dependent, alpha 2/delta subunit 2a
chr15_-_25126842 0.60 ENSDART00000193670
vacuolar protein sorting 53 homolog (S. cerevisiae)
chr8_-_25771474 0.60 ENSDART00000193883
suppressor of variegation 3-9 homolog 1b
chr9_+_22632126 0.59 ENSDART00000139434
ets variant 5a
chr17_-_6955082 0.58 ENSDART00000109228
zinc finger and BTB domain containing 24
chr7_-_15185811 0.58 ENSDART00000031049
si:dkey-172h23.2
chr8_-_14080534 0.57 ENSDART00000042867
death effector domain containing
chr3_+_32080403 0.57 ENSDART00000124943
aldehyde dehydrogenase 16 family, member A1
chr5_+_33067283 0.57 ENSDART00000085821
neuropeptide FF receptor 2b
chr13_-_25750910 0.57 ENSDART00000111567
sphingosine-1-phosphate lyase 1
chr9_-_7213772 0.57 ENSDART00000174720
ENSDART00000092435
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_43594864 0.57 ENSDART00000139980
zinc finger, FYVE domain containing 28
chr6_+_12527725 0.57 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr9_-_12034444 0.57 ENSDART00000038651
zinc finger protein 804A
chr23_-_27505825 0.56 ENSDART00000137229
ENSDART00000013797
ankyrin repeat and SOCS box containing 8
chr24_-_21090447 0.56 ENSDART00000136507
ENSDART00000140786
ENSDART00000184841
queuine tRNA-ribosyltransferase accessory subunit 2
chr9_-_49964810 0.56 ENSDART00000167098
sodium channel, voltage-gated, type I, alpha
chr21_-_21178410 0.56 ENSDART00000185277
ENSDART00000141341
ENSDART00000145872
ENSDART00000079678
FtsJ RNA methyltransferase homolog 1
chr19_+_37925616 0.56 ENSDART00000148348
neurexophilin 1
chr9_+_33340311 0.56 ENSDART00000140064
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
chr2_+_36114194 0.56 ENSDART00000113547
T-cell receptor alpha joining 39
chr7_-_21905851 0.55 ENSDART00000111066
ENSDART00000020288
erythropoietin a
chr3_+_32749613 0.55 ENSDART00000053684
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
chr16_+_25068576 0.55 ENSDART00000125838
im:7147486
chr20_+_29690901 0.55 ENSDART00000142669
membrane bound O-acyltransferase domain containing 2b
chr19_+_43579786 0.55 ENSDART00000138404
si:ch211-199g17.2
chr11_-_15850794 0.55 ENSDART00000185946
RAP1A, member of RAS oncogene family b
chr4_+_16768961 0.54 ENSDART00000143926

chr10_-_7555326 0.54 ENSDART00000162191
ENSDART00000186945
Werner syndrome
chr25_-_7670616 0.54 ENSDART00000131583
ENSDART00000142794
Bet1 golgi vesicular membrane trafficking protein-like
chr22_-_24992532 0.54 ENSDART00000102751
si:dkey-179j5.5
chr8_-_22274222 0.54 ENSDART00000131805
nephronophthisis 4
chr16_-_12095144 0.54 ENSDART00000145106
peroxisomal biogenesis factor 5
chr12_-_13905307 0.53 ENSDART00000152400
DBF4 zinc finger B
chr20_+_32523576 0.53 ENSDART00000147319
Scm polycomb group protein like 4
chr5_+_31283576 0.53 ENSDART00000133743
calcium/calmodulin-dependent protein kinase kinase 1, alpha a
chr6_-_29051773 0.53 ENSDART00000190508
ENSDART00000180191
ENSDART00000111682
ecotropic viral integration site 5b
chr10_+_20392656 0.53 ENSDART00000160803
R3H domain and coiled-coil containing 1
chr9_+_24126223 0.53 ENSDART00000132045
post-GPI attachment to proteins 1
chr9_+_17982737 0.52 ENSDART00000192569
A kinase (PRKA) anchor protein 11
chr24_-_18809433 0.52 ENSDART00000152009
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr12_+_13344896 0.52 ENSDART00000089017
ribonuclease type III, nuclear
chr20_-_23426339 0.52 ENSDART00000004625
zygote arrest 1
chr12_-_4835378 0.52 ENSDART00000172093
si:ch211-93e11.8
chr13_-_33207367 0.51 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
thyroid hormone receptor interactor 11
chr4_-_14624481 0.51 ENSDART00000137847
plexin b2a
chr7_-_40959667 0.51 ENSDART00000084070
RNA binding motif protein 33a
chr6_+_19948043 0.51 ENSDART00000182636
phosphoinositide-3-kinase, regulatory subunit 5
chr2_-_22530969 0.51 ENSDART00000159641
zinc finger protein 644a
chr7_+_71586485 0.51 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr3_-_60589292 0.51 ENSDART00000157822
jumonji domain containing 6
chr18_-_6824518 0.51 ENSDART00000141132
protein phosphatase 6, regulatory subunit 2b
chr2_+_23039041 0.51 ENSDART00000056921
casein kinase 1, gamma 2a
chr2_-_26604208 0.51 ENSDART00000133508
ENSDART00000006748
Yip1 domain family, member 1
chr15_+_37936458 0.51 ENSDART00000154491
si:ch73-380l3.2
chr6_+_49021703 0.51 ENSDART00000149394
solute carrier family 16 (monocarboxylate transporter), member 1a
chr3_-_3439150 0.51 ENSDART00000021286
si:dkey-46g23.5
chr14_+_21722235 0.50 ENSDART00000183667
syntaxin 3A
chr21_+_37477001 0.50 ENSDART00000114778
angiomotin
chr16_-_10223741 0.50 ENSDART00000188099
si:rp71-15i12.1
chr24_+_8904741 0.50 ENSDART00000140924
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr9_-_32158288 0.50 ENSDART00000037182
ankyrin repeat domain 44
chr11_+_31380495 0.50 ENSDART00000185073
signal-induced proliferation-associated 1 like 2
chr23_+_19564392 0.50 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr20_-_39789846 0.49 ENSDART00000188418
ring finger protein 217
chr13_-_4134141 0.49 ENSDART00000132354
tight junction associated protein 1 (peripheral)
chr8_-_40442979 0.49 ENSDART00000157698
ENSDART00000192657
TBC1 domain family, member 10Aa
chr9_+_23770666 0.49 ENSDART00000182493
si:ch211-219a4.3
chr9_+_8364553 0.48 ENSDART00000190713
si:dkey-90l23.2
chr2_+_8717155 0.48 ENSDART00000018114
ENSDART00000137872
ENSDART00000133037
ubiquitin specific peptidase 33
chr1_+_47331644 0.48 ENSDART00000053284
B cell CLL/lymphoma 9
chr10_+_3145707 0.47 ENSDART00000160046
hypermethylated in cancer 2
chr11_-_28911172 0.47 ENSDART00000168493
immunoglobin superfamily, member 21a
chr16_-_8120203 0.47 ENSDART00000193430
SNF related kinase a
chr18_-_21746421 0.47 ENSDART00000188809
protein serine kinase H1
chr7_-_24719655 0.46 ENSDART00000052805
cap methyltransferase 2
chr5_-_18474486 0.46 ENSDART00000090580
si:dkey-215k6.1
chr10_-_35108683 0.46 ENSDART00000049633
zgc:110006
chr2_-_26603958 0.46 ENSDART00000143085
Yip1 domain family, member 1
chr10_+_585719 0.46 ENSDART00000180167
SMAD family member 4a
chr21_+_10076203 0.46 ENSDART00000190383

chr21_-_14174786 0.45 ENSDART00000145366
whirlin a
chr24_-_20321012 0.45 ENSDART00000163683
mitogen-activated protein kinase kinase kinase 20
chr22_+_34701848 0.45 ENSDART00000082066
ATPase H+ transporting V0 subunit e2
chr25_+_4581214 0.45 ENSDART00000185552

chr5_+_7279104 0.45 ENSDART00000190014
si:ch73-72b7.1
chr11_+_37803773 0.45 ENSDART00000019047
SRY (sex determining region Y)-box 13
chr25_-_12203952 0.45 ENSDART00000158204
ENSDART00000091727
neurotrophic tyrosine kinase, receptor, type 3a
chr4_+_5848229 0.45 ENSDART00000161101
ENSDART00000067357
LYR motif containing 5a
chr8_+_26396552 0.44 ENSDART00000087151
aminomethyltransferase
chr25_-_7670391 0.44 ENSDART00000044970
Bet1 golgi vesicular membrane trafficking protein-like
chr4_-_5019113 0.44 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr4_-_14191434 0.44 ENSDART00000142374
ENSDART00000136730
pseudouridylate synthase 7-like
chr13_-_36525982 0.44 ENSDART00000114744
phosphofurin acidic cluster sorting protein 2
chr23_+_27789795 0.44 ENSDART00000141458
lysine (K)-specific methyltransferase 2D
chr21_+_33311622 0.44 ENSDART00000163808
si:ch211-151g22.1
chr11_-_27953135 0.43 ENSDART00000168338
endothelin converting enzyme 1
chr13_-_8353515 0.43 ENSDART00000080351
ENSDART00000190842
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
chr2_+_50608099 0.43 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2e3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0001207 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.3 0.9 GO:0035046 pronuclear migration(GO:0035046)
0.3 1.9 GO:0040016 embryonic cleavage(GO:0040016)
0.3 0.5 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 0.9 GO:0044806 multicellular organism aging(GO:0010259) G-quadruplex DNA unwinding(GO:0044806)
0.2 1.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.2 0.8 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.2 1.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.7 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 0.7 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.2 1.5 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 0.7 GO:0006590 thyroid hormone generation(GO:0006590)
0.2 0.7 GO:0090234 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.2 0.6 GO:2000623 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 2.7 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:0048917 posterior lateral line ganglion development(GO:0048917)
0.1 1.3 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 0.7 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.4 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.4 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.9 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.1 1.3 GO:0014074 response to purine-containing compound(GO:0014074) response to ATP(GO:0033198) response to organophosphorus(GO:0046683)
0.1 0.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.4 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.5 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.9 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 0.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.4 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 0.6 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.1 0.7 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.1 0.6 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 0.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.3 GO:0010039 response to iron ion(GO:0010039)
0.1 0.3 GO:0042117 monocyte activation(GO:0042117)
0.1 0.4 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.1 0.5 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.5 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.3 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 0.6 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.1 0.2 GO:0061511 centriole elongation(GO:0061511)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 1.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.2 GO:0003403 optic vesicle formation(GO:0003403)
0.1 0.4 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.1 0.6 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.5 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.7 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.3 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.1 0.6 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.2 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.1 0.2 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 0.4 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.7 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.9 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.3 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:1905133 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 1.1 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.6 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.4 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.8 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0021634 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) optic nerve formation(GO:0021634)
0.0 0.4 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 1.5 GO:0051298 centrosome duplication(GO:0051298)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.9 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.4 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0043111 replication fork arrest(GO:0043111)
0.0 0.5 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 1.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.4 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.6 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 1.3 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.4 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:0009450 gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 1.3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.4 GO:0060173 limb development(GO:0060173)
0.0 0.5 GO:1990090 response to nerve growth factor(GO:1990089) cellular response to nerve growth factor stimulus(GO:1990090)
0.0 0.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.3 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.1 GO:0061081 positive regulation of cytokine-mediated signaling pathway(GO:0001961) macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of response to cytokine stimulus(GO:0060760) positive regulation of macrophage cytokine production(GO:0060907) positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081) myeloid leukocyte cytokine production(GO:0061082)
0.0 0.4 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 3.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.3 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.6 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.0 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 0.6 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 1.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.3 GO:0060021 palate development(GO:0060021)
0.0 0.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.3 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 1.2 GO:0006400 tRNA modification(GO:0006400)
0.0 1.0 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 0.0 GO:0034475 U4 snRNA 3'-end processing(GO:0034475) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.5 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.1 GO:1900044 regulation of histone ubiquitination(GO:0033182) negative regulation of histone ubiquitination(GO:0033183) histone H2A K63-linked ubiquitination(GO:0070535) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.0 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0006203 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 1.0 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 1.1 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.6 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.4 GO:0016197 endosomal transport(GO:0016197)
0.0 0.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.8 GO:0017148 negative regulation of translation(GO:0017148)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 0.8 GO:0019185 snRNA-activating protein complex(GO:0019185)
0.2 0.9 GO:0044609 DBIRD complex(GO:0044609)
0.1 1.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 0.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.9 GO:0071914 prominosome(GO:0071914)
0.1 0.6 GO:0000938 GARP complex(GO:0000938)
0.1 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.4 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.1 0.3 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.3 GO:0097546 ciliary base(GO:0097546)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.7 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.4 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.9 GO:0071565 nBAF complex(GO:0071565)
0.0 0.8 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.5 GO:0005903 brush border(GO:0005903)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 1.1 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.9 GO:0005769 early endosome(GO:0005769)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 1.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 1.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 2.7 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 0.9 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.2 0.6 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.2 0.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 0.5 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 1.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.9 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.4 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.1 0.3 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.8 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.4 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.3 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.3 GO:1901612 cardiolipin binding(GO:1901612)
0.1 2.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.4 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 1.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.5 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.1 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.2 GO:0046403 polynucleotide 3'-phosphatase activity(GO:0046403)
0.1 0.5 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.2 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIF-class transcription factor binding(GO:0001096)
0.1 1.2 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.3 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.4 GO:0035198 miRNA binding(GO:0035198)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.7 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0004776 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.0 0.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.1 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 2.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.4 GO:0008266 poly-pyrimidine tract binding(GO:0008187) poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960)
0.0 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0032184 SUMO binding(GO:0032183) SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.4 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.6 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 4.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.6 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.4 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 4.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.7 GO:0015370 solute:sodium symporter activity(GO:0015370)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.5 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID REELIN PATHWAY Reelin signaling pathway
0.1 1.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 0.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.1 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.6 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID PI3KCI PATHWAY Class I PI3K signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 0.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 0.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 1.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling