ISMARA results: nr2c1

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PRJNA195909:zebrafish embryo and larva development

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Results for nr2c1

Z-value: 1.60

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Transcription factors associated with nr2c1

Gene Symbol	Gene ID	Gene Info
nr2c1 NCBI UniProt	ENSDARG00000045527	nuclear receptor subfamily 2, group C, member 1
nr2c1 NCBI UniProt	ENSDARG00000111803	nuclear receptor subfamily 2, group C, member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr2c1	dr11_v1_chr4_-_25858620_25858620	-0.94	1.8e-04	Click!

Activity profile of nr2c1 motif

Sorted Z-values of nr2c1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_-_43866526 Show fit	4.29	ENSDART00000111309	treh NCBI UniProt Show fit	trehalase (brush-border membrane glycoprotein)
chr21_+_1119046 Show fit	4.23	ENSDART00000184678	CABZ01088049.1 NCBI UniProt Show fit
chr6_+_154556 Show fit	3.95	ENSDART00000193153	zglp1 NCBI UniProt Show fit	zinc finger, GATA-like protein 1
chr10_-_21362071 Show fit	3.81	ENSDART00000125167	avd NCBI UniProt Show fit	avidin
chr19_-_8798178 Show fit	3.26	ENSDART00000188232	cers2a NCBI UniProt Show fit	ceramide synthase 2a
chr3_-_34724879 Show fit	2.76	ENSDART00000177021	thraa NCBI UniProt Show fit	thyroid hormone receptor alpha a
chr18_+_27515640 Show fit	2.47	ENSDART00000181593	tp53i11b NCBI UniProt Show fit	tumor protein p53 inducible protein 11b
chr18_-_43866001 Show fit	2.46	ENSDART00000150218	treh NCBI UniProt Show fit	trehalase (brush-border membrane glycoprotein)
chr5_+_29851433 Show fit	2.42	ENSDART00000143434	ubash3ba NCBI UniProt Show fit	ubiquitin associated and SH3 domain containing Ba
chr1_+_24387659 Show fit	2.40	ENSDART00000130356	qdprb2 NCBI UniProt Show fit	quinoid dihydropteridine reductase b2

Showing 1 to 10 of 194 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2c1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	6.8	GO:0005991	trehalose metabolic process(GO:0005991)
0.1	3.9	GO:0048599	oocyte development(GO:0048599)
1.1	3.3	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.1	3.3	GO:0046513	ceramide biosynthetic process(GO:0046513)
0.4	3.1	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.3	2.8	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154)
0.5	2.5	GO:1901842	regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2	2.4	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.6	2.3	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.6	2.3	GO:1902373	negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)

Showing 1 to 10 of 77 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5	2.3	GO:1990923	PET complex(GO:1990923)
0.1	1.7	GO:0015030	Cajal body(GO:0015030)
0.0	1.7	GO:0032156	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	1.5	GO:0030173	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.5	1.4	GO:1990072	TRAPPIII protein complex(GO:1990072)
0.1	1.4	GO:0017119	Golgi transport complex(GO:0017119)
0.1	1.4	GO:0005921	gap junction(GO:0005921)
0.1	1.3	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	1.2	GO:0001772	immunological synapse(GO:0001772)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	6.8	GO:0004555	alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1	4.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	4.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.8	3.8	GO:0009374	biotin binding(GO:0009374)
0.2	3.3	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.9	2.8	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0	2.8	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0	2.8	GO:0030246	carbohydrate binding(GO:0030246)
0.1	2.5	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	2.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 63 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.3	ST STAT3 PATHWAY	STAT3 Pathway
0.0	2.1	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.4	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	1.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.2	PID E2F PATHWAY	E2F transcription factor network
0.0	0.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.9	PID P73PATHWAY	p73 transcription factor network
0.0	0.8	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.3	PID ARF6 PATHWAY	Arf6 signaling events

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	6.8	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.4	3.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	2.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	2.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	1.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	1.2	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.0	1.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	1.0	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	0.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	0.8	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane

Showing 1 to 10 of 19 entries

Results for nr2c1

Z-value: 1.60

Motif logo

Transcription factors associated with nr2c1

Activity-expression correlation:

Activity profile of nr2c1 motif

Sorted Z-values of nr2c1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2c1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: