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PRJNA195909:zebrafish embryo and larva development

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Results for noto+vax1

Z-value: 0.46

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Transcription factors associated with noto+vax1

Gene Symbol Gene ID Gene Info
ENSDARG00000021201 notochord homeobox
ENSDARG00000021916 ventral anterior homeobox 1
ENSDARG00000114230 ventral anterior homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
notodr11_v1_chr13_+_14976108_14976108-0.684.3e-02Click!
vax1dr11_v1_chr17_-_21441464_214414640.078.6e-01Click!

Activity profile of noto+vax1 motif

Sorted Z-values of noto+vax1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_47446158 0.65 ENSDART00000152857
formin 2b
chr5_+_20257225 0.64 ENSDART00000127919
slingshot protein phosphatase 1a
chr13_-_35808904 0.63 ENSDART00000171667
mitogen-activated protein kinase kinase kinase 4
chr19_-_18313303 0.61 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
chr2_+_50608099 0.59 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr19_+_41464870 0.47 ENSDART00000102778
distal-less homeobox 6a
chr14_+_51056605 0.46 ENSDART00000159639

chr5_-_15283509 0.46 ENSDART00000052712
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
chr9_-_14683574 0.45 ENSDART00000144022
par-3 family cell polarity regulator beta b
chr8_-_22274222 0.45 ENSDART00000131805
nephronophthisis 4
chr22_-_21897203 0.43 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr2_-_38284648 0.42 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr20_-_18382708 0.39 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr6_+_32382743 0.37 ENSDART00000190009
dedicator of cytokinesis 7
chr19_+_32401278 0.35 ENSDART00000184353
ataxin 1a
chr16_-_22544047 0.34 ENSDART00000131657
cingulin a
chr16_-_7828838 0.31 ENSDART00000191434
ENSDART00000108653
T cell activation inhibitor, mitochondrial
chr25_+_2361721 0.30 ENSDART00000172905
zmp:0000000932
chr11_-_13107106 0.29 ENSDART00000184477
ELOVL fatty acid elongase 1b
chr6_+_40354424 0.29 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr18_+_5137241 0.28 ENSDART00000159601
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr20_-_1635922 0.28 ENSDART00000181502

chr18_-_43884044 0.27 ENSDART00000087382
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr19_-_20430892 0.27 ENSDART00000111409
TBC1 domain family, member 5
chr15_+_31701716 0.27 ENSDART00000113370
beta 3-glucosyltransferase a
chr7_-_12464412 0.26 ENSDART00000178723
ADAMTS-like 3
chr17_-_3815693 0.26 ENSDART00000161207
phospholipase C beta 4
chr10_+_28160265 0.25 ENSDART00000022484
ring finger protein, transmembrane 1
chr10_-_2524917 0.24 ENSDART00000188642

chr19_+_2631565 0.24 ENSDART00000171487
family with sequence similarity 126, member A
chr6_-_57539141 0.24 ENSDART00000156967
itchy E3 ubiquitin protein ligase a
chr12_+_48803098 0.23 ENSDART00000074768
peptidylprolyl isomerase Fb
chr21_+_8427059 0.23 ENSDART00000143151
DENN/MADD domain containing 1A
chr12_+_34891529 0.23 ENSDART00000015643
tubulin folding cofactor C
chr8_-_25034411 0.22 ENSDART00000135973
nuclear transcription factor Y, alpha, like
chr8_-_52562672 0.21 ENSDART00000159333
ENSDART00000159974
si:ch73-199g24.2
chr4_+_9011448 0.21 ENSDART00000192357
sorting and assembly machinery component 50 homolog, like
chr8_-_39822917 0.20 ENSDART00000067843
zgc:162025
chr6_-_19271210 0.20 ENSDART00000163628
ENSDART00000159124
zgc:174863
chr2_-_43123949 0.20 ENSDART00000075347
ENSDART00000132346
leucine rich repeat containing 6
chr11_+_11303458 0.19 ENSDART00000162486
ENSDART00000160703
si:dkey-23f9.4
chr2_-_39558643 0.19 ENSDART00000139860
ENSDART00000145231
ENSDART00000141721
cerebellin 7
chr2_-_2957970 0.19 ENSDART00000162505
si:ch1073-82l19.1
chr4_+_21129752 0.18 ENSDART00000169764
synaptotagmin Ia
chr15_+_44366556 0.17 ENSDART00000133449
guanylate cyclase 1 soluble subunit alpha 2
chr13_-_24257631 0.15 ENSDART00000146524
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr17_+_21902058 0.15 ENSDART00000142178
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr1_+_513986 0.15 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr2_-_26720854 0.14 ENSDART00000148110
si:dkey-181m9.8
chr6_-_30954268 0.13 ENSDART00000154523
phosphodiesterase 4B, cAMP-specific a
chr5_+_41477954 0.11 ENSDART00000185871
protein inhibitor of activated STAT, 2
chr12_+_22580579 0.11 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr9_-_54248182 0.11 ENSDART00000129540
leucyl-tRNA synthetase a
chr10_-_33621739 0.11 ENSDART00000142655
ENSDART00000128049
hormonally up-regulated Neu-associated kinase
chr18_-_2727764 0.11 ENSDART00000160841
si:ch211-248g20.5
chr6_-_40922971 0.10 ENSDART00000155363
SFI1 centrin binding protein
chr16_+_43765993 0.10 ENSDART00000149154
si:dkey-122a22.2
chr14_+_22591624 0.09 ENSDART00000108987
GDNF family receptor alpha 4b
chr3_-_32902138 0.08 ENSDART00000144026
ENSDART00000083874
ENSDART00000145443
ENSDART00000148239
ENSDART00000134917
K(lysine) acetyltransferase 7a
chr10_+_16036246 0.08 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr20_+_29209767 0.08 ENSDART00000141252
katanin p80 subunit B-like 1
chr14_+_30762131 0.08 ENSDART00000145039
si:ch211-145o7.3
chr19_+_9295244 0.07 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
chr20_-_37813863 0.07 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr6_+_3280939 0.07 ENSDART00000151359
lysine (K)-specific demethylase 4A, genome duplicate a
chr23_-_1348933 0.07 ENSDART00000168981

chr7_-_46777876 0.06 ENSDART00000193954
teashirt zinc finger homeobox 3b
chr5_+_41477526 0.06 ENSDART00000153567
protein inhibitor of activated STAT, 2
chr16_-_13818061 0.06 ENSDART00000132982
ENSDART00000144856
leukocyte receptor cluster (LRC) member 9
chr22_-_2959005 0.05 ENSDART00000040701
inhibitor of growth family, member 5a
chr17_+_16046314 0.05 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr18_+_9362455 0.05 ENSDART00000187025
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr1_-_31534089 0.05 ENSDART00000007770
ladybird homeobox 1b
chr10_-_26744131 0.05 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr13_+_15190677 0.05 ENSDART00000142240
ENSDART00000129045
mitochondrial antiviral signaling protein
chr7_+_65261576 0.04 ENSDART00000169566
beta-carotene oxygenase 1
chr18_+_17827149 0.04 ENSDART00000190237
ENSDART00000189345
si:ch211-216l23.1
chr24_+_19415124 0.03 ENSDART00000186931
sulfatase 1
chr6_-_40581376 0.03 ENSDART00000185412
translocator protein
chr2_-_21819421 0.03 ENSDART00000121586
chromodomain helicase DNA binding protein 7
chr15_+_31899312 0.03 ENSDART00000155315
furry homolog a (Drosophila)
chr1_-_7970653 0.03 ENSDART00000188909
si:dkey-79f11.7
chr25_+_36338289 0.03 ENSDART00000187881
zgc:165555
chr21_-_42876565 0.02 ENSDART00000126480
zmp:0000001268
chr16_+_45425181 0.02 ENSDART00000168591
PHD finger protein 1
chr8_+_25034544 0.01 ENSDART00000123300
neugrin, neurite outgrowth associated
chr1_-_51719110 0.01 ENSDART00000190574
ribonuclease H2, subunit A
chr3_-_27601812 0.01 ENSDART00000077734
zgc:66160
chr13_+_8677166 0.01 ENSDART00000181016
ENSDART00000135028
PROP paired-like homeobox 1
chr14_-_36320506 0.01 ENSDART00000074639
epidermal growth factor

Network of associatons between targets according to the STRING database.

First level regulatory network of noto+vax1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.2 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.3 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0097065 anterior head development(GO:0097065)
0.0 0.4 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 0.3 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.4 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway