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PRJNA195909:zebrafish embryo and larva development

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Results for nkx3.3-1

Z-value: 0.76

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Transcription factors associated with nkx3.3-1

Gene Symbol Gene ID Gene Info
ENSDARG00000110589 NK3 homeobox 3

Activity profile of nkx3.3-1 motif

Sorted Z-values of nkx3.3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_33308045 1.19 ENSDART00000149711
solute carrier family 4 (anion exchanger), member 2b
chr4_+_9467049 0.88 ENSDART00000012659
zgc:55888
chr9_+_8380728 0.87 ENSDART00000133501
si:ch1073-75o15.4
chr6_-_1820606 0.86 ENSDART00000183228

chr19_-_6840506 0.81 ENSDART00000081568
transcription factor 19 (SC1), like
chr6_-_31987940 0.79 ENSDART00000132280
receptor tyrosine kinase-like orphan receptor 1
chr8_-_51507144 0.78 ENSDART00000024882
ENSDART00000135166
fibroblast growth factor receptor 1a
chr5_+_57726425 0.77 ENSDART00000134684
ferredoxin-fold anticodon binding domain containing 1
chr6_-_31739709 0.69 ENSDART00000087964
cache domain containing 1
chr3_-_60886984 0.68 ENSDART00000170974
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_-_41135215 0.68 ENSDART00000001861
solute carrier family 6 member 22, tandem duplicate 1
chr2_-_57918314 0.64 ENSDART00000138265
si:dkeyp-68b7.7
chr13_-_50463938 0.63 ENSDART00000083857
cyclin J
chr19_+_8612839 0.63 ENSDART00000144925
sorting nexin family member 27a
chr21_+_4256291 0.61 ENSDART00000148138
leucine rich repeat containing 8 VRAC subunit Aa
chr23_-_29812667 0.61 ENSDART00000006120
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr13_+_33462232 0.60 ENSDART00000177841
zgc:136302
chr2_-_57900430 0.60 ENSDART00000132245
ENSDART00000140060
si:dkeyp-68b7.7
chr4_-_5077158 0.60 ENSDART00000155915
adenosylhomocysteinase-like 2
chr20_+_23498255 0.59 ENSDART00000149922
palladin, cytoskeletal associated protein
chr15_+_45595385 0.57 ENSDART00000161937
ENSDART00000170214
ENSDART00000157450
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr25_+_28282274 0.57 ENSDART00000164502
aminoadipate-semialdehyde synthase
chr8_+_10869183 0.56 ENSDART00000188111
bromodomain and PHD finger containing, 3b
chr18_-_29977431 0.55 ENSDART00000135357
si:ch211-220f16.2
chr21_-_30026359 0.55 ENSDART00000153645
PWWP domain containing 2A
chr5_+_13870340 0.54 ENSDART00000160690
hexokinase 2
chr7_+_36467796 0.53 ENSDART00000146202
akt interacting protein
chr11_+_31680513 0.52 ENSDART00000139900
ENSDART00000040305
diaphanous-related formin 3
chr25_+_2361721 0.52 ENSDART00000172905
zmp:0000000932
chr19_-_29302249 0.51 ENSDART00000188751
serum response factor binding protein 1
chr5_-_57204352 0.51 ENSDART00000171252
ENSDART00000180727
mannosidase, alpha, class 2A, member 1
chr6_+_58622831 0.50 ENSDART00000128793
Sp7 transcription factor
chr5_-_54712159 0.50 ENSDART00000149207
cyclin B1
chr7_+_20260172 0.50 ENSDART00000012450
dishevelled segment polarity protein 2
chr10_-_7472323 0.48 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
neuregulin 1
chr12_+_29236274 0.48 ENSDART00000006505
mix-type homeobox gene 2
chr16_+_3982590 0.47 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr21_+_15435946 0.47 ENSDART00000137491
si:dkey-11o15.10
chr23_-_24542952 0.47 ENSDART00000088777
ATPase 13A2
chr17_-_25831569 0.46 ENSDART00000148743
hedgehog acyltransferase
chr22_-_16755885 0.46 ENSDART00000036467
PATJ, crumbs cell polarity complex component
chr19_+_32321797 0.46 ENSDART00000167664
ataxin 1a
chr5_-_38248347 0.46 ENSDART00000084917
ENSDART00000139479
solute carrier family 12, member 9
chr8_-_51753604 0.45 ENSDART00000007090
T-box 16
chr4_-_14642379 0.44 ENSDART00000114977
si:ch211-127b11.1
chr1_-_58887610 0.44 ENSDART00000180647
microfibril-associated glycoprotein 4-like precursor
chr16_-_22585289 0.44 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cingulin a
chr7_-_23777445 0.44 ENSDART00000173527
si:ch211-200p22.4
chr6_-_12275836 0.43 ENSDART00000189980
plakophilin 4
chr20_+_46741074 0.43 ENSDART00000145294
si:ch211-57i17.1
chr16_-_13612650 0.42 ENSDART00000080372
D site albumin promoter binding protein b
chr23_+_25172976 0.41 ENSDART00000140789
si:dkey-151g10.3
chr7_-_70283372 0.41 ENSDART00000112969
adhesion G protein-coupled receptor A3
chr11_+_27134116 0.41 ENSDART00000129736
histone deacetylase 11
chr10_-_33343244 0.40 ENSDART00000164191
C2 calcium-dependent domain containing 2
chr23_-_26227805 0.40 ENSDART00000158082

chr5_-_55848511 0.40 ENSDART00000183503
calcium/calmodulin-dependent protein kinase IV
chr5_-_5243079 0.39 ENSDART00000130576
ENSDART00000164377
multivesicular body subunit 12Ba
chr6_+_515181 0.38 ENSDART00000171374
si:ch73-379f7.5
chr16_+_27444098 0.37 ENSDART00000157690
inversin
chr4_-_14649158 0.37 ENSDART00000145737
si:dkey-183c2.4
chr21_+_18925318 0.37 ENSDART00000136182
si:ch211-222n4.2
chr7_-_5487593 0.37 ENSDART00000136594
Rho guanine nucleotide exchange factor (GEF) 11
chr3_-_31069776 0.37 ENSDART00000167462
elongin B
chr5_+_44846280 0.36 ENSDART00000084370
KN motif and ankyrin repeat domains 1a
chr8_-_43689324 0.36 ENSDART00000159904
E1A binding protein p400
chr23_-_17003533 0.35 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr16_+_38240027 0.35 ENSDART00000111081
prune exopolyphosphatase
chr12_+_16087077 0.35 ENSDART00000141898
zinc finger protein 281b
chr20_-_33675676 0.35 ENSDART00000147168
rho-associated, coiled-coil containing protein kinase 2b
chr8_-_14554785 0.35 ENSDART00000057645
quiescin Q6 sulfhydryl oxidase 1
chr10_+_37268854 0.34 ENSDART00000131897
neurofibromin 1b
chr3_+_14581643 0.34 ENSDART00000182840
zinc finger protein 653
chr14_-_51014292 0.34 ENSDART00000029797
Fas associated factor family member 2
chr3_+_11926030 0.33 ENSDART00000081367
DnaJ (Hsp40) homolog, subfamily A, member 3A
chr12_-_45304971 0.33 ENSDART00000186537
ENSDART00000126405
ferredoxin reductase
chr4_-_8030583 0.32 ENSDART00000113628
si:ch211-240l19.8
chr8_-_4031121 0.32 ENSDART00000169474
ENSDART00000163754
myotubularin related protein 3
chr8_-_8446430 0.32 ENSDART00000137382
cyclin-dependent kinase 16
chr16_+_6750289 0.31 ENSDART00000167736
zinc finger protein 236
chr13_+_23093743 0.31 ENSDART00000148034
phosphoinositide-3-kinase adaptor protein 1
chr18_+_22174630 0.31 ENSDART00000089549
RHO family interacting cell polarization regulator 1
chr16_-_12097558 0.31 ENSDART00000123142
peroxisomal biogenesis factor 5
chr22_-_27113332 0.31 ENSDART00000146951
ENSDART00000178855
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr25_+_33033633 0.31 ENSDART00000192336
talin 2b
chr11_-_5953636 0.30 ENSDART00000140960
ENSDART00000123601
DET1 and DDB1 associated 1
chr8_+_8712446 0.30 ENSDART00000158674
ELK1, member of ETS oncogene family
chr5_-_57820873 0.30 ENSDART00000089961
salt-inducible kinase 2a
chr17_-_16069905 0.29 ENSDART00000110383
microtubule-associated protein 7a
chr17_+_21817859 0.29 ENSDART00000143832
ENSDART00000141462
IKAROS family zinc finger 5
chr24_-_41195068 0.29 ENSDART00000121592
activin A receptor type 2Ba
chr5_+_29652198 0.29 ENSDART00000184083
TSC complex subunit 1a
chr5_-_8907819 0.29 ENSDART00000188523
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr16_-_26132122 0.29 ENSDART00000157787
lipase, hormone-sensitive b
chr5_-_29122834 0.29 ENSDART00000087197
whirlin b
chr22_+_7480465 0.29 ENSDART00000034545
zgc:92745
chr3_-_52899394 0.29 ENSDART00000128223
coiled-coil-helix-coiled-coil-helix domain containing 5
chr19_-_43757568 0.29 ENSDART00000058491
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr22_+_9922301 0.28 ENSDART00000105924
bloody fingers
chr16_+_46725087 0.28 ENSDART00000008920
RAB11a, member RAS oncogene family, like
chr14_-_36763302 0.28 ENSDART00000074786
cathepsin O
chr11_+_19370717 0.28 ENSDART00000165906
prickle homolog 2b
chr17_+_23554932 0.28 ENSDART00000135814
pantothenate kinase 1a
chr20_-_53078607 0.28 ENSDART00000163494
ENSDART00000191730

chr5_-_23783739 0.28 ENSDART00000139502
si:ch211-287c22.1
chr19_+_791538 0.28 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr18_+_44566863 0.28 ENSDART00000176084
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr20_-_28698172 0.28 ENSDART00000190635
signal-induced proliferation-associated 1 like 1
chr22_+_32228882 0.27 ENSDART00000092082
mesencephalic astrocyte-derived neurotrophic factor
chr24_-_25166720 0.27 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr11_+_19370447 0.26 ENSDART00000186154
prickle homolog 2b
chr1_-_26045560 0.26 ENSDART00000172737
ENSDART00000076120
ENSDART00000193593
G patch domain and ankyrin repeats 1
chr11_-_2221159 0.26 ENSDART00000189292
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr7_-_30272871 0.25 ENSDART00000099586
zgc:162945
chr25_+_7299488 0.25 ENSDART00000184836
high mobility group 20A
chr22_-_31020690 0.25 ENSDART00000130604
ssu-2 homolog, tandem duplicate 4
chr1_+_55095314 0.24 ENSDART00000132727
aftiphilin a
chr1_+_18863060 0.24 ENSDART00000139241
ring finger protein 38
chr20_+_27298783 0.24 ENSDART00000013861
protein phosphatase 4, regulatory subunit 4
chr11_+_19271557 0.23 ENSDART00000190559
prickle homolog 2b
chr19_+_40248697 0.23 ENSDART00000151269
cyclin-dependent kinase 6
chr17_+_21818093 0.23 ENSDART00000125335
IKAROS family zinc finger 5
chr3_-_34753605 0.23 ENSDART00000000160
thyroid hormone receptor alpha a
chr5_-_29122615 0.23 ENSDART00000144802
whirlin b
chr14_+_49152341 0.22 ENSDART00000084114
nuclear receptor binding SET domain protein 1a
chr10_-_38468847 0.22 ENSDART00000133914
glycerophosphodiester phosphodiesterase domain containing 5a
chr9_+_51655636 0.22 ENSDART00000169908
RNA binding motif single stranded interacting protein 1
chr19_-_35155722 0.22 ENSDART00000151924
microtubule-actin crosslinking factor 1a
chr5_-_26765188 0.22 ENSDART00000029450
ring finger protein 181
chr6_+_41808673 0.22 ENSDART00000038163
RAD18 E3 ubiquitin protein ligase
chr9_-_1604601 0.22 ENSDART00000143130
alkylglycerone phosphate synthase
chr10_+_44641599 0.22 ENSDART00000172128
seizure related 6 homolog (mouse)-like
chr18_+_26829362 0.22 ENSDART00000132728
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr8_+_53051701 0.21 ENSDART00000131514
NAD kinase a
chr15_-_20709289 0.21 ENSDART00000136767
tyrosylprotein sulfotransferase 1
chr23_-_18568522 0.21 ENSDART00000004655
selenophosphate synthetase 2
chr22_-_34551568 0.21 ENSDART00000148147
ring finger protein 123
chr1_-_524433 0.21 ENSDART00000147610
si:ch73-41e3.7
chr13_+_10023256 0.21 ENSDART00000110035
S1 RNA binding domain 1
chr18_-_22094102 0.21 ENSDART00000100904
par-6 family cell polarity regulator alpha
chr1_+_55643198 0.20 ENSDART00000060693
adhesion G protein-coupled receptor E7
chr23_+_12840080 0.20 ENSDART00000081016
ENSDART00000121697
structural maintenance of chromosomes 1A, like
chr5_-_12063381 0.20 ENSDART00000026749
nipsnap homolog 1 (C. elegans)
chr23_-_21535040 0.20 ENSDART00000010647
regulator of chromosome condensation 2
chr10_-_38456382 0.20 ENSDART00000182129
glycerophosphodiester phosphodiesterase domain containing 5a
chr15_-_24676211 0.20 ENSDART00000153502
ENSDART00000100756
transmembrane protein 199
chr14_-_31814149 0.19 ENSDART00000173393
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_55916911 0.19 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
ataxia, cerebellar, Cayman type b
chr9_-_34882516 0.19 ENSDART00000011163
acetylserotonin O-methyltransferase-like
chr23_+_36601984 0.18 ENSDART00000128598
insulin-like growth factor binding protein 6b
chr24_-_11057305 0.18 ENSDART00000186494
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr7_-_40578733 0.18 ENSDART00000173926
ENSDART00000010035
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr5_-_26764880 0.18 ENSDART00000140392
ENSDART00000134728
ring finger protein 181
chr23_-_36418708 0.18 ENSDART00000132273
zinc finger protein 740b
chr14_+_21722235 0.18 ENSDART00000183667
syntaxin 3A
chr6_+_3280939 0.17 ENSDART00000151359
lysine (K)-specific demethylase 4A, genome duplicate a
chr21_+_34814444 0.17 ENSDART00000161816
WD repeat domain 55
chr25_+_11456696 0.17 ENSDART00000171408
si:ch73-141f14.1
chr25_-_37284370 0.17 ENSDART00000103222
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr16_+_20934353 0.17 ENSDART00000052660
src kinase associated phosphoprotein 2
chr4_-_2059233 0.17 ENSDART00000188177
ENSDART00000129521
ENSDART00000082289
cleavage and polyadenylation specific factor 6
chr21_+_10021823 0.17 ENSDART00000163995
hect domain and RLD 7
chr5_+_26765275 0.17 ENSDART00000144169
si:ch211-102c2.8
chr15_+_20281305 0.16 ENSDART00000155065
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr25_-_11016675 0.16 ENSDART00000099572
mesoderm posterior ab
chr1_-_30568225 0.16 ENSDART00000144297
ENSDART00000164204
UBA domain containing 2
chr6_+_46431848 0.16 ENSDART00000181056
ENSDART00000144569
ENSDART00000064865
ENSDART00000133992
staufen double-stranded RNA binding protein 1
chr1_-_49950643 0.15 ENSDART00000138301
sphingomyelin synthase 2
chr21_-_38031038 0.15 ENSDART00000179483
ENSDART00000076238
RNA binding motif protein 41
chr1_-_54706039 0.15 ENSDART00000083633
exosome component 1
chr15_+_42285643 0.15 ENSDART00000152731
SR-related CTD-associated factor 4b
chr15_+_15771418 0.15 ENSDART00000153831
si:ch211-33e4.3
chr4_-_10835620 0.14 ENSDART00000150739
PTPRF interacting protein, binding protein 1a (liprin beta 1)
chr3_-_18384501 0.14 ENSDART00000027630
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr13_+_18371208 0.14 ENSDART00000138172
cell division cycle and apoptosis regulator 1
chr21_+_26612777 0.14 ENSDART00000142667
estrogen-related receptor alpha
chr9_+_15893093 0.13 ENSDART00000099483
ENSDART00000134657
si:dkey-14o1.20
chr19_+_30990815 0.13 ENSDART00000134645
syncoilin, intermediate filament protein
chr12_+_17754859 0.13 ENSDART00000112119
basic helix-loop-helix family, member a15
chr8_-_25814263 0.13 ENSDART00000143397
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_-_35892051 0.12 ENSDART00000145884
transforming, acidic coiled-coil containing protein 3
chr6_-_59381391 0.12 ENSDART00000157066
protein phosphatase 1, regulatory subunit 16B
chr16_+_14710436 0.12 ENSDART00000027982
collagen, type XIV, alpha 1a
chr17_-_51262430 0.11 ENSDART00000163222
trafficking protein particle complex 12
chr8_-_18229169 0.11 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
chr15_-_43873005 0.11 ENSDART00000190326
NADPH oxidase 4
chr7_-_59311165 0.11 ENSDART00000171105
meiosis 1 associated protein
chr6_-_52235118 0.11 ENSDART00000191243
translocase of outer mitochondrial membrane 34
chr22_+_724639 0.11 ENSDART00000105323
zgc:162255
chr3_-_21010979 0.11 ENSDART00000109578
family with sequence similarity 117, member Aa
chr9_-_43073960 0.10 ENSDART00000059460
titin, tandem duplicate 2
chr10_+_40660772 0.10 ENSDART00000148007
trace amine associated receptor 19l
chr21_-_2158298 0.10 ENSDART00000182199
expressed sequence AI877918
chr17_+_38447473 0.10 ENSDART00000149007
codanin 1
chr21_-_21527983 0.10 ENSDART00000014254
diablo, IAP-binding mitochondrial protein b
chr22_+_1330477 0.10 ENSDART00000157567

chr12_+_8074343 0.10 ENSDART00000124084
ciliary associated calcium binding coiled-coil 1
chr8_+_25254435 0.10 ENSDART00000143554
adenosine monophosphate deaminase 2b
chr2_+_30463825 0.10 ENSDART00000092356
neuropilin (NRP) and tolloid (TLL)-like 1
chr22_-_36750589 0.10 ENSDART00000010824
aminoacylase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3.3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.2 0.6 GO:0033512 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 0.5 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.2 0.5 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) intermediate mesoderm development(GO:0048389)
0.1 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.6 GO:0039689 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 0.5 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.1 0.5 GO:0097094 regulation of osteoblast proliferation(GO:0033688) craniofacial suture morphogenesis(GO:0097094)
0.1 0.4 GO:0019075 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.1 0.4 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.1 0.5 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.8 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.2 GO:0097384 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.5 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.4 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.3 GO:2000623 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.5 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.3 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.1 0.2 GO:0046833 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 0.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.4 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.5 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.4 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.6 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 0.2 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.0 0.5 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.5 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0060912 cardiac cell fate specification(GO:0060912)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.4 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.2 GO:0060465 pharynx development(GO:0060465)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.2 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.0 0.3 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.8 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.3 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.5 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.3 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.3 GO:0009408 response to heat(GO:0009408)
0.0 0.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.0 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 0.4 GO:0030891 VCB complex(GO:0030891)
0.1 0.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.5 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.1 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.5 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.3 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 0.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 1.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 ST GA13 PATHWAY G alpha 13 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport