ISMARA results: nkx2.3+nkx2.7

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PRJNA195909:zebrafish embryo and larva development

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Results for nkx2.3+nkx2.7

Z-value: 1.27

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol	Gene ID	Gene Info
nkx2.7 NCBI UniProt	ENSDARG00000021232	NK2 transcription factor related 7
nkx2.3 NCBI UniProt	ENSDARG00000039095	NK2 homeobox 3
nkx2.3 NCBI UniProt	ENSDARG00000113490	NK2 homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nkx2.3	dr11_v1_chr13_-_40411908_40411917	0.80	8.9e-03	Click!
nkx2.7	dr11_v1_chr8_-_50287949_50287949	0.56	1.2e-01	Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_44439661 Show fit	2.23	ENSDART00000100309	crybb1l2 NCBI UniProt Show fit	crystallin, beta B1, like 2
chr12_+_15008582 Show fit	2.07	ENSDART00000003847	mylpfb NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle b
chr14_-_3381303 Show fit	2.05	ENSDART00000171601	im:7150988 NCBI UniProt Show fit	im:7150988
chr25_+_31277415 Show fit	1.90	ENSDART00000036275	tnni2a.4 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 4
chr5_-_14373662 Show fit	1.78	ENSDART00000183694	tet3 NCBI UniProt Show fit	tet methylcytosine dioxygenase 3
chr3_+_60721342 Show fit	1.66	ENSDART00000157772	foxj1a NCBI UniProt Show fit	forkhead box J1a
chr8_-_50147948 Show fit	1.65	ENSDART00000149010	hp NCBI UniProt Show fit	haptoglobin
chr25_+_20089986 Show fit	1.64	ENSDART00000143441 ENSDART00000184073	tnni4b.2 NCBI UniProt Show fit	troponin I4b, tandem duplicate 2
chr5_+_32206378 Show fit	1.62	ENSDART00000126873 ENSDART00000051361	myhz2 NCBI UniProt Show fit	myosin, heavy polypeptide 2, fast muscle specific
chr19_-_5358443 Show fit	1.61	ENSDART00000105036	cyt1l NCBI UniProt Show fit	type I cytokeratin, enveloping layer, like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0003009	skeletal muscle contraction(GO:0003009)
0.0	3.1	GO:0071466	cellular response to xenobiotic stimulus(GO:0071466)
0.5	2.5	GO:0032656	interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1	2.5	GO:0051764	actin crosslink formation(GO:0051764)
0.0	2.4	GO:0002040	sprouting angiogenesis(GO:0002040)
0.1	2.3	GO:0030199	collagen fibril organization(GO:0030199)
0.0	2.2	GO:0002088	lens development in camera-type eye(GO:0002088)
0.0	2.2	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.7	2.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3	1.7	GO:0060296	regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)

Showing 1 to 10 of 163 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0005604	basement membrane(GO:0005604)
0.1	4.1	GO:0005861	troponin complex(GO:0005861)
0.0	2.6	GO:0005882	intermediate filament(GO:0005882)
0.1	2.2	GO:0043679	axon terminus(GO:0043679)
0.0	2.2	GO:0016459	myosin complex(GO:0016459)
0.0	1.7	GO:0001726	ruffle(GO:0001726)
0.0	1.5	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	1.5	GO:0005581	collagen trimer(GO:0005581)
0.0	1.3	GO:0031941	filamentous actin(GO:0031941)
0.0	1.3	GO:0030426	growth cone(GO:0030426)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	3.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.6	GO:0005212	structural constituent of eye lens(GO:0005212)
0.4	2.5	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	2.3	GO:0005179	hormone activity(GO:0005179)
0.7	2.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.3	1.8	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	1.6	GO:0055102	phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.2	1.3	GO:0008158	hedgehog receptor activity(GO:0008158)
0.1	1.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)

Showing 1 to 10 of 94 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	1.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	1.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	0.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.9	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	0.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.3	1.8	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	1.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	1.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.1	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	1.0	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	1.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	1.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	0.9	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.9	REACTOME STEROID HORMONES	Genes involved in Steroid hormones

Showing 1 to 10 of 36 entries

Results for nkx2.3+nkx2.7

Z-value: 1.27

Motif logo

Transcription factors associated with nkx2.3+nkx2.7

Activity-expression correlation:

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: