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PRJNA195909:zebrafish embryo and larva development

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Results for nkx1.2lb

Z-value: 0.56

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Transcription factors associated with nkx1.2lb

Gene Symbol Gene ID Gene Info
nkx1.2lb
ENSDARG00000099427 NK1 transcription factor related 2-like,b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2lbdr11_v1_chr14_+_15064870_15064870-0.809.1e-03Click!

Activity profile of nkx1.2lb motif

Sorted Z-values of nkx1.2lb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_34002185 1.92 ENSDART00000046599
zar1l
zygote arrest 1-like
chr8_-_23780334 1.24 ENSDART00000145179
ENSDART00000145894
zgc:195245
zgc:195245
chr19_-_18313303 1.12 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
si:dkey-208k4.2
chr2_+_6253246 1.10 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr20_-_14114078 1.05 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
chr5_-_3991655 1.02 ENSDART00000159368
myo19
myosin XIX
chr25_-_32869794 0.88 ENSDART00000162784
tmem266
transmembrane protein 266
chr17_-_53329704 0.79 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr6_+_4255319 0.70 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr20_+_14114258 0.69 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr13_-_6279684 0.64 ENSDART00000092105
agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr14_-_30945515 0.60 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr25_+_20272145 0.59 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr11_+_31864921 0.57 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr7_-_40630698 0.52 ENSDART00000134547
ube3c
ubiquitin protein ligase E3C
chr1_-_48933 0.51 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr9_-_50000144 0.49 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha
chr17_-_15189397 0.49 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr5_-_67629263 0.48 ENSDART00000133753
zbtb20
zinc finger and BTB domain containing 20
chr12_-_4249000 0.47 ENSDART00000059298
zgc:92313
zgc:92313
chr21_-_31013817 0.47 ENSDART00000065504
ncbp3
nuclear cap binding subunit 3
chr8_-_39822917 0.46 ENSDART00000067843
zgc:162025
zgc:162025
chr8_-_20243389 0.45 ENSDART00000184904
acer1
alkaline ceramidase 1
chr7_-_59123066 0.45 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr13_-_36798204 0.45 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr13_+_35955562 0.42 ENSDART00000137377
si:ch211-67f13.7
si:ch211-67f13.7
chr25_+_36312459 0.41 ENSDART00000182484
CR354435.5

chr20_-_37813863 0.40 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr23_-_31913069 0.40 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr6_-_12275836 0.39 ENSDART00000189980
pkp4
plakophilin 4
chr13_-_36663358 0.39 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr7_+_20384408 0.37 ENSDART00000173809
si:dkey-33c9.6
si:dkey-33c9.6
chr7_-_64971839 0.37 ENSDART00000164682
sinhcafl
SIN3-HDAC complex associated factor, like
chr2_+_10006839 0.37 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr22_+_30089054 0.36 ENSDART00000185369
add3a
adducin 3 (gamma) a
chr4_+_306036 0.34 ENSDART00000103659
msgn1
mesogenin 1
chr11_+_12811906 0.34 ENSDART00000123445
rtel1
regulator of telomere elongation helicase 1
chr17_+_21902058 0.34 ENSDART00000142178
plekha1a
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr24_-_29586082 0.33 ENSDART00000136763
vav3a
vav 3 guanine nucleotide exchange factor a
chr6_+_31368071 0.32 ENSDART00000038990
jak1
Janus kinase 1
chr21_-_33995710 0.31 ENSDART00000100508
ENSDART00000179622
ebf1b
early B cell factor 1b
chr13_-_30142087 0.31 ENSDART00000110157
tysnd1
trypsin domain containing 1
chr21_+_4410733 0.30 ENSDART00000136831
ENSDART00000131612
HTRA2 (1 of many)
si:dkey-84o3.7
chr24_-_32582378 0.29 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr8_+_7756893 0.29 ENSDART00000191894
fgd1
FYVE, RhoGEF and PH domain containing 1
chr13_-_9236905 0.28 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-33c12.12
si:dkey-112g5.12
chr13_+_12761707 0.27 ENSDART00000015127
zgc:100846
zgc:100846
chr2_+_10007113 0.27 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr5_-_22052852 0.27 ENSDART00000002938
mtmr8
myotubularin related protein 8
chr3_-_40836081 0.27 ENSDART00000143135
wipi2
WD repeat domain, phosphoinositide interacting 2
chr17_+_16429826 0.26 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr8_-_4031121 0.26 ENSDART00000169474
ENSDART00000163754
mtmr3
myotubularin related protein 3
chr6_+_23026714 0.26 ENSDART00000124948
srp68
signal recognition particle 68
chr2_+_54696042 0.26 ENSDART00000074270
ankrd12
ankyrin repeat domain 12
chr5_-_33298352 0.26 ENSDART00000015076
zgc:103692
zgc:103692
chr4_+_63790028 0.25 ENSDART00000160964
si:dkey-92j16.2
si:dkey-92j16.2
chr13_-_9045879 0.25 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr13_+_9468535 0.25 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr13_-_9257728 0.23 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
HTRA2 (1 of many)
zgc:173425
chr13_-_9111927 0.23 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr9_+_16241656 0.23 ENSDART00000154326
si:ch211-261p9.4
si:ch211-261p9.4
chr13_-_9184132 0.22 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
HTRA2 (1 of many)
si:dkey-33c12.10
chr13_+_9496748 0.22 ENSDART00000147050
ENSDART00000102120
CR848040.4

chr21_+_4328348 0.22 ENSDART00000131658
ENSDART00000143799
HTRA2 (1 of many)
si:dkey-84o3.7
chr21_-_15200556 0.22 ENSDART00000141809
sfswap
splicing factor SWAP
chr12_-_19119176 0.21 ENSDART00000149180
aco2
aconitase 2, mitochondrial
chr13_-_9213207 0.20 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr1_-_44812014 0.20 ENSDART00000139044
si:dkey-9i23.8
si:dkey-9i23.8
chr13_+_9521629 0.19 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr3_+_32832538 0.19 ENSDART00000139410
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr13_-_9159852 0.19 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr21_+_4429001 0.18 ENSDART00000134520
HTRA2 (1 of many)
si:dkey-84o3.6
chr16_+_32051572 0.18 ENSDART00000039109
leng1
leukocyte receptor cluster (LRC) member 1
chr9_+_1313418 0.18 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr10_-_105100 0.18 ENSDART00000145716
ttc3
tetratricopeptide repeat domain 3
chr2_-_55298075 0.17 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr18_+_13236255 0.17 ENSDART00000091560
tldc1
TBC/LysM-associated domain containing 1
chr21_+_4368735 0.17 ENSDART00000182817
CT027677.1

chr1_+_55758257 0.17 ENSDART00000139312
tecrb
trans-2,3-enoyl-CoA reductase b
chr13_-_9070754 0.16 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
si:dkey-112g5.12
chr21_+_4348600 0.16 ENSDART00000138463
HTRA2 (1 of many)
si:dkey-84o3.2
chr7_+_24881680 0.16 ENSDART00000058843
krcp
kelch repeat-containing protein
chr25_-_7705487 0.14 ENSDART00000128099
prdm11
PR domain containing 11
chr23_-_35064785 0.14 ENSDART00000172240
BX294434.1

chr16_+_4078240 0.14 ENSDART00000160890
inpp5b
inositol polyphosphate-5-phosphatase B
chr9_+_35015747 0.14 ENSDART00000140110
gabpa
GA binding protein transcription factor, alpha subunit
chr7_+_20383841 0.13 ENSDART00000052906
si:dkey-33c9.6
si:dkey-33c9.6
chr17_+_24821627 0.12 ENSDART00000112389
wdr43
WD repeat domain 43
chr4_-_44611273 0.12 ENSDART00000156793
znf1115
zinc finger protein 1115
chr22_-_17458070 0.12 ENSDART00000139658
si:ch211-197g15.10
si:ch211-197g15.10
chr9_-_35334642 0.12 ENSDART00000157195
ncam2
neural cell adhesion molecule 2
chr20_+_36812368 0.08 ENSDART00000062931
abracl
ABRA C-terminal like
chr13_+_411607 0.07 ENSDART00000186483
CU570800.3

chr2_+_25315591 0.06 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr7_+_13418812 0.05 ENSDART00000191905
ENSDART00000091567
dagla
diacylglycerol lipase, alpha
chr4_-_42039794 0.05 ENSDART00000110313
si:dkeyp-85d8.5
si:dkeyp-85d8.5
chr23_-_1348933 0.03 ENSDART00000168981
CABZ01078120.1

chr21_-_21570134 0.03 ENSDART00000174388
or133-4
odorant receptor, family H, subfamily 133, member 4
chr14_+_918287 0.02 ENSDART00000167066
CU462913.1

chr7_+_34453185 0.02 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr2_+_19522082 0.02 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2lb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.1 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 1.5 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.6 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.5 GO:0097065 anterior head development(GO:0097065)
0.0 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.6 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.5 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.3 GO:0036268 swimming(GO:0036268)
0.0 0.3 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.0 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.3 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.7 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.0 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.0 0.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1990923 PET complex(GO:1990923)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.4 GO:0032190 acrosin binding(GO:0032190)
0.1 0.2 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 0.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.6 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)