ISMARA results: nkx1.2la

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PRJNA195909:zebrafish embryo and larva development

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Results for nkx1.2la

Z-value: 1.38

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Transcription factors associated with nkx1.2la

Gene Symbol	Gene ID	Gene Info
nkx1.2la NCBI UniProt	ENSDARG00000006350	NK1 transcription factor related 2-like,a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nkx1.2la	dr11_v1_chr13_+_40770628_40770628	0.09	8.2e-01	Click!

Activity profile of nkx1.2la motif

Sorted Z-values of nkx1.2la motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_23984179 Show fit	2.94	ENSDART00000175879	apoc2 NCBI UniProt Show fit	apolipoprotein C-II
chr4_-_9891874 Show fit	2.94	ENSDART00000067193	adm2a NCBI UniProt Show fit	adrenomedullin 2a
chr25_+_29160102 Show fit	2.81	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr8_+_16025554 Show fit	2.67	ENSDART00000110171	elavl4 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr4_+_16885854 Show fit	2.39	ENSDART00000017726	etnk1 NCBI UniProt Show fit	ethanolamine kinase 1
chr21_-_43015383 Show fit	2.38	ENSDART00000065097	dpysl3 NCBI UniProt Show fit	dihydropyrimidinase-like 3
chr15_+_23799461 Show fit	2.32	ENSDART00000154885	si:ch211-167j9.4 NCBI UniProt Show fit	si:ch211-167j9.4
chr16_-_20312146 Show fit	2.12	ENSDART00000134980	si:dkeyp-86h10.3 NCBI UniProt Show fit	si:dkeyp-86h10.3
chr23_+_19813677 Show fit	2.11	ENSDART00000139192 ENSDART00000142308	emd NCBI UniProt Show fit	emerin (Emery-Dreifuss muscular dystrophy)
chr13_-_9886579 Show fit	2.09	ENSDART00000101926	si:ch211-117n7.7 NCBI UniProt Show fit	si:ch211-117n7.7

Showing 1 to 10 of 154 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2la

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.9	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2	2.9	GO:0044872	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	2.8	GO:0006096	glycolytic process(GO:0006096)
0.2	2.4	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.4	2.1	GO:0006660	phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0	2.1	GO:0007605	sensory perception of sound(GO:0007605)
0.1	2.0	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.1	1.9	GO:0030497	fatty acid elongation(GO:0030497)
0.3	1.7	GO:0021767	mammillary body development(GO:0021767)
0.1	1.7	GO:0060325	face morphogenesis(GO:0060325)

Showing 1 to 10 of 54 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.3	GO:0030426	growth cone(GO:0030426)
0.3	2.9	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	2.0	GO:0005795	Golgi stack(GO:0005795)
0.3	1.6	GO:0042584	chromaffin granule membrane(GO:0042584)
0.0	1.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.5	GO:0005581	collagen trimer(GO:0005581)
0.2	1.4	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	1.4	GO:0034707	chloride channel complex(GO:0034707)
0.0	1.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	1.0	GO:0005858	axonemal dynein complex(GO:0005858)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	2.9	GO:0005179	hormone activity(GO:0005179)
0.5	2.8	GO:0004743	pyruvate kinase activity(GO:0004743)
0.2	2.4	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.2	2.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.3	2.0	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.5	1.9	GO:0018812	3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1	1.7	GO:0005112	Notch binding(GO:0005112)
0.0	1.6	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	1.6	GO:0008188	neuropeptide receptor activity(GO:0008188)

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.8	PID BMP PATHWAY	BMP receptor signaling
0.0	0.7	PID FGF PATHWAY	FGF signaling pathway
0.0	0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.4	2.6	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	2.4	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	2.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	1.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.8	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	0.7	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor

Showing 1 to 10 of 16 entries

Results for nkx1.2la

Z-value: 1.38

Motif logo

Transcription factors associated with nkx1.2la

Activity-expression correlation:

Activity profile of nkx1.2la motif

Sorted Z-values of nkx1.2la motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2la

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: