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PRJNA195909:zebrafish embryo and larva development

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Results for nfic

Z-value: 1.13

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Transcription factors associated with nfic

Gene Symbol Gene ID Gene Info
nfic
ENSDARG00000043210 nuclear factor I/C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nficdr11_v1_chr8_+_20776654_207766540.872.6e-03Click!

Activity profile of nfic motif

Sorted Z-values of nfic motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_55139127 3.96 ENSDART00000115324
hbae1.3
hemoglobin, alpha embryonic 1.3
chr1_+_7546259 3.59 ENSDART00000015732
mylz3
myosin, light polypeptide 3, skeletal muscle
chr10_+_44042033 3.12 ENSDART00000190006
ENSDART00000046172
cryba4
crystallin, beta A4
chr17_-_125091 2.98 ENSDART00000158825
actc1b
actin, alpha, cardiac muscle 1b
chr2_+_55982940 2.13 ENSDART00000097753
ENSDART00000097751
nmrk2
nicotinamide riboside kinase 2
chr16_+_23397785 2.08 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr19_-_5332784 1.71 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chr17_+_52822422 1.68 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr1_+_4101741 1.46 ENSDART00000163793
slitrk6
SLIT and NTRK-like family, member 6
chr1_-_44434707 1.34 ENSDART00000110148
cryba1l2
crystallin, beta A1, like 2
chr1_+_49568335 1.33 ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr11_+_13630107 1.30 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr23_+_18944388 1.22 ENSDART00000104487
cox4i2
cytochrome c oxidase subunit IV isoform 2
chr16_-_43025885 1.21 ENSDART00000193146
ENSDART00000157302
si:dkey-7j14.5
si:dkey-7j14.5
chr7_-_26306546 1.13 ENSDART00000140817
zgc:77439
zgc:77439
chr20_-_47704973 1.09 ENSDART00000174808
tfap2b
transcription factor AP-2 beta
chr7_-_26306954 1.02 ENSDART00000057288
zgc:77439
zgc:77439
chr2_-_8017579 1.00 ENSDART00000040209
ephb3a
eph receptor B3a
chr8_+_25616946 0.95 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr22_-_10487490 0.93 ENSDART00000064798
aspn
asporin (LRR class 1)
chr6_-_13114406 0.92 ENSDART00000188015
zgc:194469
zgc:194469
chr10_-_8358396 0.91 ENSDART00000059322
csgalnact1a
chondroitin sulfate N-acetylgalactosaminyltransferase 1a
chr7_-_55675617 0.87 ENSDART00000021009
ENSDART00000188631
cbfa2t3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr4_+_22365061 0.87 ENSDART00000039277
lhfpl3
LHFPL tetraspan subfamily member 3
chr16_+_50100420 0.85 ENSDART00000128167
nr1d2a
nuclear receptor subfamily 1, group D, member 2a
chr8_-_6877390 0.81 ENSDART00000170883
ENSDART00000005321
neflb
neurofilament, light polypeptide b
chr22_-_33679277 0.80 ENSDART00000169948
FO904977.1

chr14_+_20893065 0.79 ENSDART00000079452
lygl1
lysozyme g-like 1
chr17_-_43466317 0.78 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr19_+_30388186 0.77 ENSDART00000103474
tspan13b
tetraspanin 13b
chr4_+_74131530 0.74 ENSDART00000174125
CABZ01072523.1

chr12_+_30653047 0.74 ENSDART00000148562
thbs2b
thrombospondin 2b
chr1_-_28629471 0.73 ENSDART00000121758
ednrba
endothelin receptor Ba
chr19_+_43780970 0.71 ENSDART00000063870
rpl11
ribosomal protein L11
chr2_-_17827983 0.69 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr6_-_35401282 0.68 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr4_-_17629444 0.68 ENSDART00000108814
nrip2
nuclear receptor interacting protein 2
chr1_+_33328857 0.65 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr2_+_7818368 0.64 ENSDART00000007068
kcnmb2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr21_-_34658266 0.63 ENSDART00000023038
dacha
dachshund a
chr5_-_57898008 0.63 ENSDART00000050945
layna
layilin a
chr12_+_30168342 0.62 ENSDART00000142756
ablim1b
actin binding LIM protein 1b
chr20_-_25486384 0.62 ENSDART00000141340
si:dkey-183n20.15
si:dkey-183n20.15
chr19_+_9786722 0.62 ENSDART00000138310
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr14_+_8174828 0.60 ENSDART00000167228
psd2
pleckstrin and Sec7 domain containing 2
chr6_-_8295657 0.60 ENSDART00000185135
slc44a2
solute carrier family 44 (choline transporter), member 2
chr5_-_46329880 0.60 ENSDART00000156577
si:ch211-130m23.5
si:ch211-130m23.5
chr6_-_34006917 0.58 ENSDART00000190702
ENSDART00000184003
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr17_-_30863252 0.55 ENSDART00000062811
yy1a
YY1 transcription factor a
chr9_-_48937089 0.54 ENSDART00000193442
cers6
ceramide synthase 6
chr10_-_17232372 0.53 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr11_-_43948885 0.51 ENSDART00000164522
CABZ01074203.1

chr2_+_47905735 0.51 ENSDART00000159701
ftr23
finTRIM family, member 23
chr9_-_48937240 0.50 ENSDART00000075627
cers6
ceramide synthase 6
chr10_-_27566481 0.50 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr23_-_45504991 0.49 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr8_-_44223899 0.46 ENSDART00000143020
stx2b
syntaxin 2b
chr7_-_29341233 0.46 ENSDART00000140938
ENSDART00000147251
trpm1a
transient receptor potential cation channel, subfamily M, member 1a
chr10_-_1718395 0.45 ENSDART00000137620
si:ch73-46j18.5
si:ch73-46j18.5
chr5_-_68826177 0.45 ENSDART00000136605
si:ch211-283h6.4
si:ch211-283h6.4
chr12_+_35654749 0.45 ENSDART00000169889
ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr5_+_37517800 0.44 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr11_+_14284866 0.44 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr24_-_12745222 0.44 ENSDART00000151836
si:ch211-196f5.9
si:ch211-196f5.9
chr3_+_57038033 0.43 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr15_-_14469704 0.42 ENSDART00000185077
numbl
numb homolog (Drosophila)-like
chr25_-_36248053 0.42 ENSDART00000134928
nfatc3b
nuclear factor of activated T cells 3b
chr7_+_36898850 0.41 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr10_+_7636811 0.39 ENSDART00000160673
hint1
histidine triad nucleotide binding protein 1
chr8_-_14375890 0.38 ENSDART00000090306
xpr1a
xenotropic and polytropic retrovirus receptor 1a
chr15_+_31806303 0.37 ENSDART00000155902
frya
furry homolog a (Drosophila)
chr2_+_31665836 0.37 ENSDART00000135411
ENSDART00000143914
si:ch211-106h4.12
si:ch211-106h4.12
chr9_+_37152564 0.36 ENSDART00000189497
gli2a
GLI family zinc finger 2a
chr20_-_42100932 0.34 ENSDART00000191930
slc35f1
solute carrier family 35, member F1
chr8_-_44223473 0.32 ENSDART00000098525
stx2b
syntaxin 2b
chr11_-_42980535 0.31 ENSDART00000181160
ENSDART00000192064
CABZ01069998.1

chr20_-_33976305 0.29 ENSDART00000111022
sele
selectin E
chr17_-_10309766 0.29 ENSDART00000160994
ttc6
tetratricopeptide repeat domain 6
chr7_+_36898622 0.28 ENSDART00000190773
tox3
TOX high mobility group box family member 3
chr23_+_25822742 0.27 ENSDART00000184436
r3hdml
R3H domain containing-like
chr9_-_23884937 0.27 ENSDART00000141377
FAM124A
si:dkeyp-74a11.1
chr21_+_38634296 0.26 ENSDART00000114467
AL935199.1

chr10_-_16065185 0.26 ENSDART00000187266
si:dkey-184a18.5
si:dkey-184a18.5
chr24_-_31942656 0.25 ENSDART00000180308
ENSDART00000016879
c1ql3a
complement component 1, q subcomponent-like 3a
chr4_+_61171310 0.24 ENSDART00000141738
si:dkey-9p20.18
si:dkey-9p20.18
chr22_-_15693085 0.23 ENSDART00000141861
si:ch1073-396h14.1
si:ch1073-396h14.1
chr6_+_41186320 0.23 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr22_+_32120156 0.22 ENSDART00000149666
dock3
dedicator of cytokinesis 3
chr24_-_22756508 0.22 ENSDART00000035409
ENSDART00000146247
zc2hc1a
zinc finger, C2HC-type containing 1A
chr19_+_9091673 0.21 ENSDART00000052898
si:ch211-81a5.5
si:ch211-81a5.5
chr7_+_52135791 0.20 ENSDART00000098705
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr4_-_38033800 0.20 ENSDART00000159662
si:dkeyp-82b4.4
si:dkeyp-82b4.4
chr9_-_23885220 0.18 ENSDART00000112058
FAM124A
si:dkeyp-74a11.1
chr3_+_57997980 0.17 ENSDART00000168477
ENSDART00000193840
pycr1a
pyrroline-5-carboxylate reductase 1a
chr16_+_33143503 0.16 ENSDART00000058471
ENSDART00000179385
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr17_+_5846202 0.16 ENSDART00000189713
fndc4b
fibronectin type III domain containing 4b
chr14_+_23811808 0.13 ENSDART00000014411
kctd16a
potassium channel tetramerization domain containing 16a
chr3_+_31039923 0.13 ENSDART00000147706
cox6a2
cytochrome c oxidase subunit VIa polypeptide 2
chr13_-_22774491 0.13 ENSDART00000189320
si:ch211-150i13.1
si:ch211-150i13.1
chr21_+_39361040 0.13 ENSDART00000085453
cluhb
clustered mitochondria (cluA/CLU1) homolog b
chr1_+_28089703 0.12 ENSDART00000166989
psip1a
PC4 and SFRS1 interacting protein 1a
chr20_+_51464670 0.12 ENSDART00000150110
thbd
thrombomodulin
chr24_-_35707552 0.12 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr20_+_48739154 0.11 ENSDART00000100262
zgc:110348
zgc:110348
chr15_+_21672281 0.11 ENSDART00000153923
si:dkey-40g16.5
si:dkey-40g16.5
chr20_-_47188966 0.11 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr21_+_10866421 0.10 ENSDART00000137858
alpk2
alpha-kinase 2
chr3_-_37681824 0.08 ENSDART00000185858
gpatch8
G patch domain containing 8
chr17_-_35352690 0.05 ENSDART00000016053
rnf144aa
ring finger protein 144aa
chr1_+_35194454 0.05 ENSDART00000165389
sc:d189
sc:d189
chr6_-_35032792 0.05 ENSDART00000168256
ddr2a
discoidin domain receptor tyrosine kinase 2a
chr3_-_38777553 0.05 ENSDART00000193045
znf281a
zinc finger protein 281a
chr3_-_40528333 0.05 ENSDART00000193047
actb2
actin, beta 2
chr2_+_6303639 0.04 ENSDART00000132859
otol1a
otolin 1a
chr22_-_29083070 0.04 ENSDART00000104812
ENSDART00000172576
cbx6a
chromobox homolog 6a
chr12_+_4160804 0.04 ENSDART00000152515
itgam
integrin, alpha M (complement component 3 receptor 3 subunit)
chr6_+_7533601 0.03 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr15_-_18091157 0.02 ENSDART00000153848
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr5_+_55225497 0.02 ENSDART00000144087
tmc2a
transmembrane channel-like 2a
chr2_+_16460321 0.02 ENSDART00000145107
agfg1b
ArfGAP with FG repeats 1b
chr3_-_34279109 0.02 ENSDART00000183255
tnrc6c1
trinucleotide repeat containing 6C1
chr10_+_40684758 0.01 ENSDART00000133648
taar19h
trace amine associated receptor 19h
chr9_-_46382637 0.00 ENSDART00000085738
lct
lactase
chr23_-_18572685 0.00 ENSDART00000047175
ssr4
signal sequence receptor, delta
chr20_-_8110672 0.00 ENSDART00000113993
si:ch211-232i5.1
si:ch211-232i5.1

Network of associatons between targets according to the STRING database.

First level regulatory network of nfic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 1.0 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.2 4.0 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0015871 choline transport(GO:0015871)
0.1 0.6 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 0.5 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.7 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.6 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 0.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 4.5 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.7 GO:0050935 iridophore differentiation(GO:0050935)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.6 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.5 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.2 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.8 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 1.7 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.7 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.7 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.4 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.4 GO:0009154 purine ribonucleotide catabolic process(GO:0009154)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.0 GO:0005869 dynactin complex(GO:0005869)
0.2 0.5 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 0.8 GO:0005883 neurofilament(GO:0005883)
0.1 1.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.0 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 GO:0031720 haptoglobin binding(GO:0031720)
0.3 2.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.2 2.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.6 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.7 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.9 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 1.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 2.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 4.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.8 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway