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PRJNA195909:zebrafish embryo and larva development

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Results for nfia

Z-value: 2.43

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Transcription factors associated with nfia

Gene Symbol Gene ID Gene Info
ENSDARG00000062420 nuclear factor I/A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfiadr11_v1_chr22_-_16997887_169978870.684.6e-02Click!

Activity profile of nfia motif

Sorted Z-values of nfia motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_55139127 6.12 ENSDART00000115324
hemoglobin, alpha embryonic 1.3
chr25_+_20089986 4.09 ENSDART00000143441
ENSDART00000184073
troponin I4b, tandem duplicate 2
chr12_-_17712393 3.80 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr5_-_32292965 3.78 ENSDART00000183522
ENSDART00000131983
myosin, heavy polypeptide 1.2, skeletal muscle
chr3_+_23221047 3.78 ENSDART00000009393
collagen, type I, alpha 1a
chr21_+_26390549 3.55 ENSDART00000185643
thymosin, beta
chr12_+_42436328 3.51 ENSDART00000167324
early B cell factor 3a
chr13_+_30804367 3.38 ENSDART00000053946
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
chr16_-_55028740 3.35 ENSDART00000156368
ENSDART00000161704
zgc:114181
chr9_-_22182396 3.08 ENSDART00000101809
crystallin, gamma M2d6
chr5_+_32228538 3.07 ENSDART00000077471
myosin heavy chain 4
chr2_+_2470687 3.06 ENSDART00000184024
ENSDART00000061955
myosin, light chain 13
chr7_+_29951997 3.04 ENSDART00000173453
alpha-tropomyosin
chr5_-_71705191 3.03 ENSDART00000187767
adenylate kinase 1
chr15_-_23645810 2.94 ENSDART00000168845
creatine kinase, muscle b
chr24_+_2519761 2.92 ENSDART00000106619
neuritin 1a
chr9_-_42696408 2.87 ENSDART00000144744
collagen, type V, alpha 2a
chr5_-_32309129 2.80 ENSDART00000123003
myosin, heavy polypeptide 1.1, skeletal muscle
chr12_+_13256415 2.72 ENSDART00000144542
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr16_-_13595027 2.72 ENSDART00000060004
ntl-dependent gene 5
chr3_+_31621774 2.71 ENSDART00000076636
frizzled class receptor 2
chr11_+_30729745 2.64 ENSDART00000103270
solute carrier family 22 (organic anion transporter), member 7a
chr5_+_32222303 2.63 ENSDART00000051362
myosin heavy chain 4
chr5_+_32247310 2.62 ENSDART00000182649
myosin, heavy chain a
chr9_-_33107237 2.62 ENSDART00000013918
calsequestrin 2
chr22_+_38767780 2.50 ENSDART00000149499
alkaline phosphatase, intestinal, tandem duplicate 1
chr6_+_13742899 2.45 ENSDART00000104722
cyclin-dependent kinase 5, regulatory subunit 2a (p39)
chr15_-_29388012 2.42 ENSDART00000115032
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr23_+_20110086 2.38 ENSDART00000054664
troponin C type 1b (slow)
chr16_+_10318893 2.37 ENSDART00000055380
tubulin, beta 5
chr19_+_12915498 2.37 ENSDART00000132892
collagen triple helix repeat containing 1a
chr24_-_24038800 2.36 ENSDART00000080549
lysozyme
chr23_+_36653376 2.22 ENSDART00000053189
G protein-coupled receptor 182
chr18_-_23874929 2.20 ENSDART00000134910
nuclear receptor subfamily 2, group F, member 2
chr16_+_29650698 2.20 ENSDART00000137153
tropomodulin 4 (muscle)
chr22_+_5176255 2.15 ENSDART00000092647
ceramide synthase 1
chr16_-_45209684 2.14 ENSDART00000184595
FXYD domain containing ion transport regulator 1 (phospholemman)
chr15_-_26552393 2.14 ENSDART00000150152
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr20_+_25340814 2.12 ENSDART00000063028
connective tissue growth factor a
chr3_-_50865079 2.09 ENSDART00000164295
peripheral myelin protein 22a
chr15_-_29387446 2.08 ENSDART00000145976
ENSDART00000035096
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr20_+_26702377 2.07 ENSDART00000077753
forkhead box C1b
chr12_+_42436920 2.06 ENSDART00000177303
early B cell factor 3a
chr23_+_31107685 2.05 ENSDART00000103448
T-box 18
chr25_+_34576067 2.05 ENSDART00000157519
transient receptor potential cation channel, subfamily M, member 1b
chr7_-_60831082 1.94 ENSDART00000073654
ENSDART00000136999
pyruvate carboxylase b
chr20_-_20533865 1.94 ENSDART00000125039
SIX homeobox 6b
chr20_-_44496245 1.92 ENSDART00000012229
FK506 binding protein 1b
chr17_+_33719415 1.90 ENSDART00000132294
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr18_-_40481028 1.89 ENSDART00000134177
zgc:101040
chr13_-_29424454 1.89 ENSDART00000026765
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr10_-_26738209 1.88 ENSDART00000188590
fibroblast growth factor 13b
chr15_+_7187228 1.88 ENSDART00000109394
hairy-related 13
chr6_-_55958705 1.87 ENSDART00000155963
EYA transcriptional coactivator and phosphatase 2
chr22_+_28446365 1.87 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr15_+_19652807 1.86 ENSDART00000134321
ENSDART00000054426
lens intrinsic membrane protein 2.3
chr11_-_7261717 1.81 ENSDART00000128959
zgc:113223
chr21_-_44104600 1.74 ENSDART00000044599
organic anion transporter X
chr9_-_6927587 1.71 ENSDART00000059092
transmembrane protein 182a
chr18_+_22994113 1.71 ENSDART00000171871
core-binding factor, beta subunit
chr8_-_16259063 1.71 ENSDART00000057590
DMRT-like family A2
chr25_+_14507567 1.69 ENSDART00000015681
developing brain homeobox 1b
chr17_+_10242166 1.68 ENSDART00000170420
C-type lectin domain containing 14A
chr18_+_15706160 1.67 ENSDART00000131524
si:ch211-264e16.1
chr23_+_21663631 1.67 ENSDART00000066125
dehydrogenase/reductase (SDR family) member 3a
chr23_-_10175898 1.63 ENSDART00000146185
keratin 5
chr5_-_28679135 1.63 ENSDART00000193585
tenascin C
chr14_-_21064199 1.62 ENSDART00000172099
si:dkey-74k8.3
chr2_+_38161318 1.61 ENSDART00000044264
matrix metallopeptidase 14b (membrane-inserted)
chr21_+_21374277 1.60 ENSDART00000079431
reticulon 2b
chr11_-_25418856 1.60 ENSDART00000013714
GATA binding protein 1a
chr17_-_21793113 1.59 ENSDART00000104612
H6 family homeobox 3a
chr4_-_16412084 1.57 ENSDART00000188460
decorin
chr10_+_39084354 1.56 ENSDART00000158245
si:ch73-1a9.3
chr16_+_20915319 1.56 ENSDART00000079383
homeobox A9b
chr18_-_20636549 1.55 ENSDART00000060259
wingless-type MMTV integration site family member 2
chr4_+_19535946 1.54 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
leucine rich repeat containing 4.1
chr7_-_17028015 1.53 ENSDART00000022441
developing brain homeobox 1a
chr14_-_21063977 1.53 ENSDART00000164373
si:dkey-74k8.3
chr22_-_26945493 1.53 ENSDART00000077411
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr22_+_5106751 1.53 ENSDART00000138967
ataxia, cerebellar, Cayman type a
chr17_+_33453689 1.52 ENSDART00000156894
Ras and Rab interactor 3
chr14_+_18785727 1.52 ENSDART00000184452
si:ch211-111e20.1
chr14_-_32016615 1.51 ENSDART00000105761
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr1_+_26667872 1.50 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemogen
chr18_+_27318589 1.50 ENSDART00000037813
CD81 molecule b
chr21_-_20932603 1.49 ENSDART00000138155
ENSDART00000079709
complement component 6
chr25_+_34014523 1.48 ENSDART00000182856
annexin A2a
chr16_-_38553721 1.47 ENSDART00000109124
R-spondin 2
chr17_+_18117358 1.47 ENSDART00000144894
B cell CLL/lymphoma 11Ba
chr19_-_3381422 1.46 ENSDART00000105146
endothelin 1
chr4_-_16341801 1.45 ENSDART00000140190
keratocan
chr23_-_11870962 1.45 ENSDART00000143481
si:dkey-178k16.1
chr3_-_53533128 1.44 ENSDART00000183591
notch 3
chr22_+_5176693 1.44 ENSDART00000160927
ceramide synthase 1
chr15_-_26552652 1.42 ENSDART00000152336
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr19_-_9711472 1.41 ENSDART00000016197
ENSDART00000175075
solute carrier family 2 (facilitated glucose transporter), member 3a
chr9_+_34089156 1.39 ENSDART00000000005
coiled-coil domain containing 80
chr22_-_23253252 1.36 ENSDART00000175556
LIM homeobox 9
chr17_-_6382392 1.35 ENSDART00000188051
ENSDART00000192560
ENSDART00000137389
ENSDART00000115389
taxilin beta b
chr11_-_45185792 1.35 ENSDART00000171328
si:dkey-93h22.7
chr7_+_18364176 1.35 ENSDART00000171606
ENSDART00000186368
CD248 molecule, endosialin a
chr6_-_40771813 1.35 ENSDART00000076200
H1 histone family, member X
chr10_-_17988779 1.34 ENSDART00000132206
ENSDART00000144841
si:dkey-242g16.2
chr8_+_46217861 1.34 ENSDART00000038790
angiopoietin-like 7
chr10_-_28761454 1.34 ENSDART00000129400
activated leukocyte cell adhesion molecule a
chr17_+_51627209 1.33 ENSDART00000056886
zgc:113142
chr16_-_29277164 1.32 ENSDART00000058870
Rh family, B glycoprotein (gene/pseudogene)
chr7_-_51321126 1.32 ENSDART00000067647
RAS-like, family 11, member A
chr19_+_19762183 1.30 ENSDART00000163611
ENSDART00000187604
homeobox A3a
chr14_+_13454840 1.30 ENSDART00000161854
plastin 3 (T isoform)
chr16_+_31802203 1.30 ENSDART00000058739
ENSDART00000110834
wingless-type MMTV integration site family, member 4b
chr14_+_32022272 1.30 ENSDART00000105760
zic family member 6
chr13_+_24834199 1.29 ENSDART00000101274
zgc:153981
chr23_+_23658474 1.29 ENSDART00000162838
agrin
chr10_-_22057001 1.29 ENSDART00000016575
T cell leukemia homeobox 3b
chr4_+_4232562 1.28 ENSDART00000177529
small lysine rich protein 1
chr3_+_32557615 1.27 ENSDART00000151608
paired box 10
chr21_-_36972127 1.26 ENSDART00000100310
drebrin 1
chr5_-_51830997 1.26 ENSDART00000163616
homer scaffolding protein 1b
chr15_+_27364394 1.26 ENSDART00000122101
T-box 2b
chr13_+_27951688 1.26 ENSDART00000050303
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr25_-_15045338 1.25 ENSDART00000161165
ENSDART00000165774
ENSDART00000172538
paired box 6a
chr15_-_34567370 1.25 ENSDART00000099793
sclerostin domain containing 1a
chr5_-_41831646 1.24 ENSDART00000134326
si:dkey-65b12.6
chr10_+_39263827 1.23 ENSDART00000172509
FAD-dependent oxidoreductase domain containing 1
chr18_+_44649804 1.23 ENSDART00000059063
EH-domain containing 2b
chr1_-_22861348 1.23 ENSDART00000139412
si:dkey-92j12.6
chr25_+_28772632 1.23 ENSDART00000160619
solute carrier family 41 (magnesium transporter), member 2a
chr5_+_37837245 1.22 ENSDART00000171617
ependymin
chr11_+_13630107 1.22 ENSDART00000172220
si:ch211-1a19.3
chr1_+_49568335 1.22 ENSDART00000142957
collagen, type XVII, alpha 1a
chr5_-_33460959 1.20 ENSDART00000085636
si:ch211-182d3.1
chr14_-_30808174 1.20 ENSDART00000173262
protease, serine, 23
chr17_-_19535328 1.20 ENSDART00000077809
cytochrome P450, family 26, subfamily C, polypeptide 1
chr5_-_67911111 1.19 ENSDART00000051833
GS homeobox 1
chr3_+_26044969 1.19 ENSDART00000133523
HMG box domain containing 4a
chr5_-_48268049 1.18 ENSDART00000187454
myocyte enhancer factor 2cb
chr21_+_11503212 1.17 ENSDART00000146701
si:dkey-184p9.7
chr20_+_19066858 1.17 ENSDART00000192086
SRY (sex determining region Y)-box 7
chr10_+_43189325 1.17 ENSDART00000185584
versican b
chr15_-_20468302 1.17 ENSDART00000018514
deltaC
chr24_-_17039638 1.16 ENSDART00000048823
complement component 8, gamma polypeptide
chr8_+_48613040 1.15 ENSDART00000121432
natriuretic peptide A
chr17_-_32863250 1.14 ENSDART00000167292
prospero homeobox 1a
chr8_+_15254564 1.14 ENSDART00000024433
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr1_+_47446032 1.13 ENSDART00000126904
ENSDART00000007262
gap junction protein alpha 8 paralog b
chr9_-_48370645 1.13 ENSDART00000140185
collagen, type XXVIII, alpha 2a
chr9_-_34296406 1.13 ENSDART00000125451
immunoglobulin-like domain containing receptor 2
chr18_-_21271373 1.11 ENSDART00000060001
purine nucleoside phosphorylase 6
chr17_+_38573471 1.09 ENSDART00000040627
spectrin, beta, erythrocytic
chr17_-_30666037 1.09 ENSDART00000156509
ALK and LTK ligand 2b
chr10_+_21576909 1.09 ENSDART00000168604
ENSDART00000166533
protocadherin 1 alpha 3
chr3_-_51912019 1.09 ENSDART00000149914
apoptosis-associated tyrosine kinase a
chr21_-_22730832 1.08 ENSDART00000101797
F-box protein 40, tandem duplicate 1
chr3_-_50046004 1.07 ENSDART00000109544
si:ch1073-100f3.2
chr19_-_10243148 1.06 ENSDART00000148073
shisa family member 7
chr7_-_27037990 1.06 ENSDART00000173561
nucleobindin 2a
chr12_-_31009315 1.06 ENSDART00000133854
transcription factor 7 like 2
chr8_-_25980694 1.05 ENSDART00000135456
si:dkey-72l14.3
chr1_+_37391141 1.04 ENSDART00000083593
ENSDART00000168647
SPARC-like 1
chr5_+_53482597 1.04 ENSDART00000180333

chr18_+_22994427 1.03 ENSDART00000173131
ENSDART00000172995
ENSDART00000172923
ENSDART00000141521
ENSDART00000173201
ENSDART00000059961
core-binding factor, beta subunit
chr14_-_7128980 1.03 ENSDART00000171311
si:ch73-43g23.1
chr21_-_4032650 1.02 ENSDART00000151648
netrin g2b
chr23_-_24148646 1.02 ENSDART00000113598
Rho guanine nucleotide exchange factor (GEF) 19
chr25_-_10503043 1.01 ENSDART00000155404
cytochrome c oxidase subunit 8b
chr7_-_27686021 1.01 ENSDART00000079112
ENSDART00000100989
calcitonin/calcitonin-related polypeptide, alpha
chr9_-_1949915 1.01 ENSDART00000190712
homeobox D3a
chr14_-_26704829 1.01 ENSDART00000078563
neurogenin 1
chr3_+_15176737 1.00 ENSDART00000065805
tetraspanin 10
chr7_-_50517023 0.99 ENSDART00000073910
ADAMTS like 5
chr2_-_8017579 0.98 ENSDART00000040209
eph receptor B3a
chr8_+_29593986 0.98 ENSDART00000077642
atonal bHLH transcription factor 1a
chr7_+_54605640 0.98 ENSDART00000168474
fibroblast growth factor 3
chr6_+_21202639 0.98 ENSDART00000083126
cell death-inducing DFFA-like effector c
chr18_+_30508729 0.98 ENSDART00000185140
cytochrome c oxidase subunit IV isoform 1
chr3_-_32541033 0.97 ENSDART00000151476
ENSDART00000055324
reticulocalbin 3, EF-hand calcium binding domain
chr3_-_58644920 0.97 ENSDART00000155953
dehydrogenase/reductase (SDR family) member 7Ca
chr1_+_40801696 0.97 ENSDART00000147497
carboxypeptidase Z
chr23_-_4855122 0.97 ENSDART00000133701
solute carrier family 6 (neurotransmitter transporter), member 1a
chr9_-_6372535 0.97 ENSDART00000149189
esophageal cancer related gene 4a
chr12_+_26471712 0.96 ENSDART00000162115
nudE neurodevelopment protein 1-like 1a
chr7_+_65939098 0.96 ENSDART00000193599
Ras association domain family member 10
chr12_-_31012741 0.96 ENSDART00000145967
transcription factor 7 like 2
chr9_+_21151138 0.95 ENSDART00000133903
hydroxyacid oxidase 2 (long chain)
chr1_-_9644630 0.95 ENSDART00000123725
ENSDART00000161164
UDP glucuronosyltransferase 5 family, polypeptide B3
chr14_+_36886950 0.95 ENSDART00000183719
si:ch211-132p1.3
chr8_+_8468139 0.95 ENSDART00000186684
catechol-O-methyltransferase a
chr17_+_42842632 0.95 ENSDART00000155547
ENSDART00000126087
glutaminyl-peptide cyclotransferase
chr6_-_24301324 0.94 ENSDART00000171401

chr5_+_52067723 0.94 ENSDART00000166902
SET binding protein 1
chr16_+_12521872 0.94 ENSDART00000114411
Ras interacting protein 1
chr21_+_45733871 0.94 ENSDART00000187285
ENSDART00000193018
zgc:77058
chr8_+_8973425 0.93 ENSDART00000066107
B cell receptor associated protein 31
chr21_+_22630627 0.93 ENSDART00000193092
si:dkeyp-69c1.7
chr16_+_1254390 0.91 ENSDART00000092627
ADAMTS like 4
chr4_+_74131530 0.90 ENSDART00000174125

chr16_+_5579744 0.90 ENSDART00000147973
microtubule-actin crosslinking factor 1 b
chr19_-_24443867 0.90 ENSDART00000163763
ENSDART00000043133
thrombospondin 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of nfia

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
0.9 3.8 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.9 2.7 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.9 3.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 2.2 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.7 2.6 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.6 1.9 GO:0042908 xenobiotic transport(GO:0042908)
0.6 3.1 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.5 1.6 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.5 4.3 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.5 2.1 GO:0035790 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.5 2.0 GO:0010226 response to lithium ion(GO:0010226)
0.5 1.5 GO:0033335 anal fin development(GO:0033335)
0.5 1.4 GO:0035019 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.5 3.3 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.5 1.4 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.4 2.2 GO:0048664 neuron fate determination(GO:0048664)
0.4 1.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.4 1.3 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.4 1.6 GO:0030224 monocyte differentiation(GO:0030224)
0.4 2.0 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.4 1.1 GO:1905072 cardiac jelly development(GO:1905072)
0.3 1.0 GO:0021985 neurohypophysis development(GO:0021985)
0.3 1.0 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 2.1 GO:0060017 parathyroid gland development(GO:0060017)
0.3 0.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 0.9 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.3 0.9 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.3 1.2 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.3 1.5 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.3 0.8 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.3 1.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.3 1.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 1.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.3 2.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.3 1.0 GO:0021516 dorsal spinal cord development(GO:0021516)
0.2 0.7 GO:0071314 response to cocaine(GO:0042220) cellular response to alkaloid(GO:0071312) cellular response to cocaine(GO:0071314)
0.2 2.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 5.1 GO:0015671 oxygen transport(GO:0015671)
0.2 0.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 0.9 GO:0018199 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.2 0.9 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 2.9 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.1 GO:0070378 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.2 1.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 1.1 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.2 1.9 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 0.6 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.3 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.2 0.6 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.2 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.7 GO:0014909 smooth muscle cell migration(GO:0014909)
0.2 1.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 1.3 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.2 0.7 GO:0021742 abducens nucleus development(GO:0021742)
0.2 1.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 0.9 GO:0090527 actin filament reorganization(GO:0090527)
0.2 1.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 0.6 GO:0015859 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.2 0.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 0.9 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.2 1.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.1 7.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 1.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.5 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.5 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.6 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.1 3.5 GO:0019835 cytolysis(GO:0019835)
0.1 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.9 GO:0046686 response to cadmium ion(GO:0046686)
0.1 1.2 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 1.9 GO:0036065 fucosylation(GO:0036065)
0.1 1.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.8 GO:0021570 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.1 0.2 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 3.9 GO:0050654 chondroitin sulfate proteoglycan metabolic process(GO:0050654)
0.1 4.3 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.6 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.7 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.1 0.8 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 1.7 GO:0021984 adenohypophysis development(GO:0021984)
0.1 0.4 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.1 0.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.3 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 1.6 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.8 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.1 1.9 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.4 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.1 0.9 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 0.8 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.1 GO:0002090 regulation of receptor internalization(GO:0002090)
0.1 0.5 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.8 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.4 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 0.4 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 0.7 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 0.2 GO:0015874 norepinephrine transport(GO:0015874)
0.1 0.8 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.1 0.5 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.9 GO:0090109 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.4 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 0.4 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.9 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 0.1 GO:0032095 regulation of response to food(GO:0032095)
0.1 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.5 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.7 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.1 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.4 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.3 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 0.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.5 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.1 0.1 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.4 GO:0010573 vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574) positive regulation of vascular endothelial growth factor production(GO:0010575) esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.3 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.3 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 4.3 GO:0021510 spinal cord development(GO:0021510)
0.1 0.2 GO:0071435 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.1 0.5 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.8 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 1.2 GO:0003171 atrioventricular valve development(GO:0003171)
0.0 0.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 2.0 GO:0060402 cytosolic calcium ion transport(GO:0060401) calcium ion transport into cytosol(GO:0060402)
0.0 0.5 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.5 GO:0051350 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.0 2.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 11.0 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.1 GO:0032814 natural killer cell activation(GO:0030101) regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.0 4.2 GO:0031101 fin regeneration(GO:0031101)
0.0 0.4 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.2 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 1.3 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 1.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 1.2 GO:0060840 artery development(GO:0060840)
0.0 0.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.2 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.4 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.3 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 0.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.3 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.9 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.8 GO:0010842 retina layer formation(GO:0010842)
0.0 0.6 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) potassium ion homeostasis(GO:0055075) sodium ion export(GO:0071436)
0.0 0.3 GO:0072506 phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.0 2.8 GO:0006936 muscle contraction(GO:0006936)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.6 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.8 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 1.6 GO:1901214 regulation of neuron death(GO:1901214)
0.0 1.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.0 GO:0016331 morphogenesis of embryonic epithelium(GO:0016331)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.8 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:0042476 odontogenesis(GO:0042476)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.5 GO:0008272 sulfate transport(GO:0008272)
0.0 3.6 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.2 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.5 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 1.3 GO:0010770 positive regulation of cell morphogenesis involved in differentiation(GO:0010770)
0.0 3.1 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 0.2 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.7 GO:2000181 negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.5 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 1.2 GO:0048469 cell maturation(GO:0048469)
0.0 0.3 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 0.4 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.1 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.0 0.1 GO:0007140 male meiosis(GO:0007140)
0.0 0.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0005588 collagen type V trimer(GO:0005588)
0.6 3.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.5 2.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.4 5.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 2.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.3 1.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 1.8 GO:0030428 cell septum(GO:0030428)
0.2 1.1 GO:0008091 spectrin(GO:0008091)
0.2 3.5 GO:0005579 membrane attack complex(GO:0005579)
0.2 7.6 GO:0005861 troponin complex(GO:0005861)
0.2 0.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 1.7 GO:0042583 chromaffin granule(GO:0042583)
0.2 1.8 GO:0045095 keratin filament(GO:0045095)
0.2 0.5 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.9 GO:0005922 connexon complex(GO:0005922)
0.1 2.2 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 0.7 GO:0005883 neurofilament(GO:0005883)
0.1 2.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 14.0 GO:0016459 myosin complex(GO:0016459)
0.1 2.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 8.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 1.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.4 GO:0046930 pore complex(GO:0046930)
0.0 2.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.0 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.1 GO:0030427 site of polarized growth(GO:0030427)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 3.9 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 1.3 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 38.5 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 14.9 GO:0005576 extracellular region(GO:0005576)
0.0 0.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0016234 inclusion body(GO:0016234)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.8 GO:0008305 integrin complex(GO:0008305)
0.0 0.7 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.6 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0055037 recycling endosome(GO:0055037)
0.0 0.9 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.6 2.4 GO:0003796 lysozyme activity(GO:0003796)
0.4 5.1 GO:0031720 haptoglobin binding(GO:0031720)
0.4 1.1 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.3 1.0 GO:0031716 calcitonin receptor binding(GO:0031716)
0.3 0.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 1.9 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.3 1.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.3 3.1 GO:0016805 dipeptidase activity(GO:0016805)
0.3 2.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 1.5 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 2.2 GO:0001972 retinoic acid binding(GO:0001972)
0.3 3.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.3 1.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 0.7 GO:0016496 substance P receptor activity(GO:0016496)
0.2 4.9 GO:0042056 chemoattractant activity(GO:0042056)
0.2 3.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.2 0.9 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.2 3.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 1.8 GO:0004100 chitin synthase activity(GO:0004100)
0.2 1.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 2.9 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 1.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2 1.1 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.2 1.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 7.6 GO:0005518 collagen binding(GO:0005518)
0.2 1.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 0.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 1.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 0.7 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 0.9 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 0.5 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.2 3.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 1.0 GO:0019215 intermediate filament binding(GO:0019215)
0.2 0.8 GO:0008432 JUN kinase binding(GO:0008432)
0.2 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.2 1.2 GO:0036122 BMP binding(GO:0036122)
0.1 0.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.0 GO:0070888 E-box binding(GO:0070888)
0.1 2.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.5 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 1.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.1 2.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.5 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 1.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 3.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 3.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 4.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.9 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.5 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.3 GO:2001069 glycogen binding(GO:2001069)
0.1 11.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 5.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.5 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.4 GO:0015288 porin activity(GO:0015288)
0.1 0.8 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 1.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 1.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.1 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.8 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.3 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 0.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 0.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.7 GO:0051787 misfolded protein binding(GO:0051787)
0.1 5.1 GO:0008201 heparin binding(GO:0008201)
0.1 0.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.4 GO:0016972 thiol oxidase activity(GO:0016972)
0.1 0.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 18.9 GO:0051015 actin filament binding(GO:0051015)
0.1 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.3 GO:0034632 retinol transporter activity(GO:0034632)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.0 GO:0010181 FMN binding(GO:0010181)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.5 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 2.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.6 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.3 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.7 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 11.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.7 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 17.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.0 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.0 2.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.7 GO:0051427 hormone receptor binding(GO:0051427)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.2 GO:0098918 structural constituent of presynaptic active zone(GO:0098882) structural constituent of synapse(GO:0098918)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 18.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 7.2 PID AP1 PATHWAY AP-1 transcription factor network
0.1 1.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.8 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 4.1 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 1.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 4.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.0 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 4.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 0.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 2.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 2.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis