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PRJNA195909:zebrafish embryo and larva development

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Results for nfat5a+nfat5b

Z-value: 0.49

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Transcription factors associated with nfat5a+nfat5b

Gene Symbol Gene ID Gene Info
ENSDARG00000020872 nuclear factor of activated T cells 5a
ENSDARG00000102556 nuclear factor of activated T cells 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfat5adr11_v1_chr25_-_37121335_37121335-0.432.5e-01Click!
nfat5bdr11_v1_chr7_+_67325933_67325933-0.363.4e-01Click!

Activity profile of nfat5a+nfat5b motif

Sorted Z-values of nfat5a+nfat5b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_39444843 0.70 ENSDART00000143999
ENSDART00000173554
ENSDART00000173698
ENSDART00000173754
ENSDART00000144075
ENSDART00000138192
ENSDART00000145457
ENSDART00000141750
ENSDART00000103056
ENSDART00000142946
ENSDART00000173748
troponin T type 3b (skeletal, fast)
chr16_+_23398369 0.69 ENSDART00000037694
S100 calcium binding protein A10b
chr16_+_23397785 0.67 ENSDART00000148961
S100 calcium binding protein A10b
chr2_+_55982940 0.59 ENSDART00000097753
ENSDART00000097751
nicotinamide riboside kinase 2
chr9_+_53725294 0.57 ENSDART00000165991
chondromodulin
chr9_+_53725128 0.55 ENSDART00000169062
chondromodulin
chr15_+_33989181 0.53 ENSDART00000169487
von Willebrand factor D and EGF domains
chr2_+_55982300 0.50 ENSDART00000183903
nicotinamide riboside kinase 2
chr6_+_2097690 0.38 ENSDART00000193770
transglutaminase 2b
chr16_+_31804590 0.37 ENSDART00000167321
wingless-type MMTV integration site family, member 4b
chr24_-_24060632 0.35 ENSDART00000090514
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr19_-_8748571 0.29 ENSDART00000031173
ribosomal protein S27, isoform 1
chr1_-_26293203 0.29 ENSDART00000180140
CXXC finger 4
chr1_+_19303241 0.28 ENSDART00000129970
si:dkeyp-118a3.2
chr9_+_310331 0.28 ENSDART00000172446
ENSDART00000187731
ENSDART00000193970
SH3 and cysteine rich domain 3
chr16_-_28836523 0.27 ENSDART00000108596
ENSDART00000142920
perilipin 6
chr14_-_25599002 0.27 ENSDART00000040955
solute carrier family 25, member 48
chr9_+_33145522 0.26 ENSDART00000005879
ATP synthase peripheral stalk subunit OSCP
chr23_+_36771593 0.26 ENSDART00000078240
membrane-associated ring finger (C3HC4) 9
chr20_-_40720458 0.26 ENSDART00000153151
ENSDART00000061261
ENSDART00000138569
connexin 43
chr20_-_29787192 0.26 ENSDART00000125348
ENSDART00000048759
inhibitor of DNA binding 2b
chr5_+_67971627 0.26 ENSDART00000144879
mitochondrial translational initiation factor 3
chr8_+_31872992 0.25 ENSDART00000146933
complement component 7a
chr2_-_6115688 0.24 ENSDART00000081663
peroxiredoxin 1
chr24_-_21923930 0.24 ENSDART00000131944
transgelin 3b
chr7_-_48667056 0.24 ENSDART00000006378
cyclin-dependent kinase inhibitor 1Ca
chr25_+_34013093 0.22 ENSDART00000011967
annexin A2a
chr16_+_20895904 0.22 ENSDART00000052662
homeobox A13b
chr10_+_22782522 0.22 ENSDART00000079498
ENSDART00000145558
si:ch211-237l4.6
chr1_-_26292897 0.22 ENSDART00000112899
ENSDART00000185410
CXXC finger 4
chr2_-_41518340 0.21 ENSDART00000130830
otolith matrix protein
chr12_-_30549022 0.21 ENSDART00000102474
zgc:158404
chr18_-_14860435 0.20 ENSDART00000018502
mitogen-activated protein kinase 12a
chr10_+_13209580 0.20 ENSDART00000000887
ENSDART00000136932
Ras association (RalGDS/AF-6) domain family 6
chr10_+_21730585 0.20 ENSDART00000188576
protocadherin 1 gamma 22
chr6_+_49095646 0.19 ENSDART00000103385
solute carrier family 25, member 55a
chr23_+_36122058 0.18 ENSDART00000184448
homeobox C3a
chr24_-_21674950 0.18 ENSDART00000123216
ENSDART00000046211
ligand of numb-protein X 2a
chr20_+_34326874 0.18 ENSDART00000061659
influenza virus NS1A binding protein a
chr21_+_26657404 0.18 ENSDART00000129035
ENSDART00000186550
peroxiredoxin 5
chr2_+_31382590 0.18 ENSDART00000086863
collectin sub-family member 12
chr23_+_28770225 0.17 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr15_+_1796313 0.17 ENSDART00000126253
family with sequence similarity 124B
chr13_-_42749916 0.17 ENSDART00000140019
calpain 2, (m/II) large subunit a
chr5_-_37900350 0.16 ENSDART00000084839
ENSDART00000084841
ENSDART00000133437
transmembrane protease, serine 13b
chr3_-_31019715 0.15 ENSDART00000156687
ENSDART00000156127
ENSDART00000153945
si:dkeyp-71f10.5
chr3_-_32590164 0.15 ENSDART00000151151
tetraspanin 4b
chr18_-_898870 0.15 ENSDART00000151777
ENSDART00000062654
poly (ADP-ribose) polymerase family, member 6a
chr21_+_5494561 0.14 ENSDART00000169728
lymphocyte antigen 6 family member M3
chr13_-_11667661 0.14 ENSDART00000102411
dynactin 1b
chr5_-_12713920 0.13 ENSDART00000099749
si:dkey-98f17.3
chr2_-_43151358 0.13 ENSDART00000061170
ENSDART00000056161
finTRIM family, member 15
chr4_+_76722754 0.13 ENSDART00000153867
membrane-spanning 4-domains, subfamily A, member 17A.3
chr3_-_35554809 0.13 ENSDART00000010944
dynactin 5
chr1_-_22834824 0.12 ENSDART00000043556
LIM domain binding 2b
chr25_+_7461624 0.12 ENSDART00000170569
synaptotagmin XII
chr2_-_20923864 0.12 ENSDART00000006870
prostaglandin-endoperoxide synthase 2a
chr22_-_32360464 0.12 ENSDART00000148886
poly(rC) binding protein 4
chr6_-_57635577 0.11 ENSDART00000168708
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr10_+_21722892 0.11 ENSDART00000162855
protocadherin 1 gamma 13
chr11_-_12051805 0.11 ENSDART00000110117
ENSDART00000182744
suppressor of cytokine signaling 7
chr7_-_56793739 0.11 ENSDART00000082842
si:ch211-146m13.3
chr21_+_22840246 0.10 ENSDART00000151621
baculoviral IAP repeat containing 2
chr7_+_56098590 0.10 ENSDART00000098453
cadherin 15, type 1, M-cadherin (myotubule)
chr23_-_26522760 0.10 ENSDART00000142417
ENSDART00000135606
ENSDART00000122668
si:dkey-205h13.1
chr8_+_7144066 0.09 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr7_-_31941670 0.09 ENSDART00000180929
ENSDART00000075389
brain-derived neurotrophic factor
chr5_-_42904329 0.09 ENSDART00000112807
chemokine (C-X-C motif) ligand 20
chr10_-_37072776 0.09 ENSDART00000110835
myosin XVIIIAa
chr24_-_24060460 0.08 ENSDART00000142813
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr21_+_44557006 0.08 ENSDART00000170159
C-x(9)-C motif containing 4 homolog (S. cerevisiae)
chr3_+_40856095 0.08 ENSDART00000143207
monocyte to macrophage differentiation-associated 2a
chr13_-_50139916 0.08 ENSDART00000099475
nidogen 1a
chr18_+_45792035 0.08 ENSDART00000135045
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr3_-_29688370 0.08 ENSDART00000151147
ENSDART00000151679
si:ch73-233k15.2
chr20_-_1174266 0.08 ENSDART00000023304
gamma-aminobutyric acid (GABA) A receptor, rho 2b
chr2_-_37888429 0.08 ENSDART00000183277
mannose binding lectin 2
chr2_-_37960688 0.07 ENSDART00000055565
cerebellin 14
chr25_+_7321675 0.07 ENSDART00000104712
ENSDART00000142934
high mobility group 20A
chr25_-_13842618 0.07 ENSDART00000160258
mitogen-activated protein kinase 8 interacting protein 1a
chr2_-_37862380 0.07 ENSDART00000186005
si:ch211-284o19.8
chr21_-_17603182 0.06 ENSDART00000020048
ENSDART00000177270
gelsolin a
chr5_-_63109232 0.06 ENSDART00000115128
ubiquitin specific peptidase 2b
chr7_+_72012397 0.06 ENSDART00000011303
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
chr6_-_42073367 0.06 ENSDART00000154304
glutamate receptor, metabotropic 2a
chr7_+_57795974 0.06 ENSDART00000148369
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr6_-_50704689 0.06 ENSDART00000074100
oxidative stress induced growth inhibitor 1
chr14_+_23970818 0.06 ENSDART00000123338
ENSDART00000124944
kinesin family member 3A
chr20_+_10498986 0.06 ENSDART00000064114
zgc:100997
chr5_-_49012569 0.06 ENSDART00000184690
si:dkey-172m14.2
chr4_+_57093908 0.05 ENSDART00000170198
si:ch211-238e22.5
chr10_-_42882215 0.05 ENSDART00000180580
ENSDART00000187374

chr13_-_41155472 0.05 ENSDART00000160588
si:dkeyp-86d6.2
chr7_+_39624728 0.05 ENSDART00000173847
ENSDART00000173845
protein tyrosine phosphatase, non-receptor type 5
chr20_+_10498704 0.04 ENSDART00000192985
zgc:100997
chr22_-_8306743 0.04 ENSDART00000123982

chr16_+_29303971 0.04 ENSDART00000087149
hyaluronan and proteoglycan link protein 2
chr21_+_2742823 0.04 ENSDART00000189004

chr16_-_21047872 0.04 ENSDART00000131582
chromobox homolog 3b
chr2_-_36925561 0.04 ENSDART00000187690
microtubule-associated protein 1Sb
chr1_+_56502706 0.04 ENSDART00000188665

chr11_-_236984 0.03 ENSDART00000170778
dual specificity phosphatase 7
chr4_+_47751483 0.03 ENSDART00000160043
si:ch211-196f19.1
chr12_-_17024079 0.03 ENSDART00000129027
interferon-induced protein with tetratricopeptide repeats 11
chr15_+_37950556 0.03 ENSDART00000153947
si:dkey-238d18.12
chr2_-_34483597 0.03 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr6_+_51932563 0.03 ENSDART00000181778
angiopoietin 4
chr17_+_24756379 0.03 ENSDART00000185059
SH3 and cysteine rich domain
chr1_-_29658721 0.03 ENSDART00000132063
si:dkey-1h24.6
chr1_+_56972616 0.03 ENSDART00000152812
si:ch211-1f22.11
chr4_-_52504961 0.03 ENSDART00000163123
si:dkey-78o7.3
chr10_+_44955106 0.02 ENSDART00000185837
interleukin 1, beta
chr23_-_31645760 0.02 ENSDART00000035031
serum/glucocorticoid regulated kinase 1
chr4_-_53047883 0.02 ENSDART00000157496
si:dkey-201g16.5
chr23_+_26102028 0.02 ENSDART00000139488
si:dkey-78k11.4
chr1_+_57041549 0.02 ENSDART00000152198
si:ch211-1f22.16
chr19_-_42416696 0.02 ENSDART00000086961
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr4_+_35594200 0.02 ENSDART00000193902
si:dkeyp-4c4.2
chr10_+_44986419 0.02 ENSDART00000162566
H2A histone family, member Vb
chr5_-_49011912 0.02 ENSDART00000097450
si:dkey-172m14.2
chr4_+_31405646 0.02 ENSDART00000128732
si:rp71-5o12.3
chr18_+_9641210 0.02 ENSDART00000182024
piccolo presynaptic cytomatrix protein b
chr14_+_18782610 0.02 ENSDART00000164468
si:ch211-111e20.1
chr10_+_1899595 0.02 ENSDART00000040271

chr10_-_40968095 0.01 ENSDART00000184104
neuropeptide FF receptor 1 like 1
chr12_-_10441661 0.01 ENSDART00000014379
ubiquinol-cytochrome c reductase core protein 2b
chr14_-_33218418 0.01 ENSDART00000163046
si:dkey-31j3.11
chr17_-_33414781 0.01 ENSDART00000142203
ENSDART00000034638
coiled-coil domain containing 28A
chr2_+_42318012 0.01 ENSDART00000138137
finTRIM family, member 8
chr4_-_52379723 0.01 ENSDART00000168272
si:dkeyp-107f9.4
chr9_+_7909490 0.01 ENSDART00000133063
ENSDART00000109288
myosin XVI
chr16_+_45746549 0.01 ENSDART00000190403
progestin and adipoQ receptor family member VI
chr17_+_12658411 0.01 ENSDART00000139918
GPN-loop GTPase 1
chr16_-_14587332 0.01 ENSDART00000012479
DNA replication and sister chromatid cohesion 1
chr2_+_23790748 0.01 ENSDART00000041877
cysteine-serine-rich nuclear protein 1a
chr3_+_22059066 0.01 ENSDART00000155739
KAT8 regulatory NSL complex subunit 1b
chr6_+_612330 0.01 ENSDART00000166872
ENSDART00000191758
kynureninase
chr2_-_24369087 0.01 ENSDART00000081237
plasmalemma vesicle associated protein a
chr13_+_22104298 0.01 ENSDART00000115393
si:dkey-174i8.1
chr3_-_40529782 0.00 ENSDART00000055194
ENSDART00000141737
actin, beta 2
chr16_+_34046733 0.00 ENSDART00000058424
family with sequence similarity 46, member Ba

Network of associatons between targets according to the STRING database.

First level regulatory network of nfat5a+nfat5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.3 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 0.3 GO:0043476 pigment accumulation(GO:0043476)
0.0 0.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.7 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.0 0.1 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.0 0.2 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.1 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.2 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 0.7 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions