ISMARA results: mycn

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PRJNA195909:zebrafish embryo and larva development

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Results for mycn

Z-value: 1.24

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Transcription factors associated with mycn

Gene Symbol	Gene ID	Gene Info
mycn NCBI UniProt	ENSDARG00000006837	MYCN proto-oncogene, bHLH transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mycn	dr11_v1_chr20_+_33294428_33294428	-0.48	2.0e-01	Click!

Activity profile of mycn motif

Sorted Z-values of mycn motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_14277003 Show fit	1.97	ENSDART00000006628	zgc:173742 NCBI UniProt Show fit	zgc:173742
chr3_+_24595922 Show fit	1.89	ENSDART00000169405	si:dkey-68o6.5 NCBI UniProt Show fit	si:dkey-68o6.5
chr15_-_17099560 Show fit	1.80	ENSDART00000101724	mos NCBI UniProt Show fit	v-mos Moloney murine sarcoma viral oncogene homolog
chr23_+_32101361 Show fit	1.77	ENSDART00000138849	zgc:56699 NCBI UniProt Show fit	zgc:56699
chr23_+_38159715 Show fit	1.61	ENSDART00000137969	zgc:112994 NCBI UniProt Show fit	zgc:112994
chr22_-_20695237 Show fit	1.51	ENSDART00000112722	org NCBI UniProt Show fit	oogenesis-related gene
chr16_-_21489514 Show fit	1.50	ENSDART00000149525 ENSDART00000148517 ENSDART00000146914 ENSDART00000186493 ENSDART00000193081 ENSDART00000186017	mpp6a NCBI UniProt Show fit	membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr13_-_12021566 Show fit	1.34	ENSDART00000125430	pprc1 NCBI UniProt Show fit	peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr5_+_68807170 Show fit	1.33	ENSDART00000017849	her7 NCBI UniProt Show fit	hairy and enhancer of split related-7
chr14_-_8940499 Show fit	1.30	ENSDART00000129030	zgc:153681 NCBI UniProt Show fit	zgc:153681

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0030488	tRNA methylation(GO:0030488)
0.4	4.1	GO:0043046	DNA methylation involved in gamete generation(GO:0043046)
0.2	2.0	GO:0009303	rRNA transcription(GO:0009303)
0.1	2.0	GO:0006265	DNA topological change(GO:0006265)
0.6	1.8	GO:1902102	meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.4	1.8	GO:1990481	mRNA pseudouridine synthesis(GO:1990481)
0.2	1.8	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	1.8	GO:0007283	spermatogenesis(GO:0007283)
0.1	1.7	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	1.7	GO:0015718	monocarboxylic acid transport(GO:0015718)

Showing 1 to 10 of 153 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.2	GO:0005730	nucleolus(GO:0005730)
0.3	2.7	GO:0071546	pi-body(GO:0071546)
0.0	2.3	GO:0000786	nucleosome(GO:0000786)
0.1	2.2	GO:0043186	P granule(GO:0043186)
0.4	1.9	GO:0031515	tRNA (m1A) methyltransferase complex(GO:0031515)
0.2	1.8	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.1	1.5	GO:0032040	small-subunit processome(GO:0032040)
0.5	1.4	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.1	1.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.3	1.1	GO:0035339	SPOTS complex(GO:0035339)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	2.5	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	2.4	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	2.2	GO:0034062	DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2	2.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.4	1.9	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0	1.9	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2	1.7	GO:0034584	piRNA binding(GO:0034584)
0.1	1.7	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	1.7	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Showing 1 to 10 of 121 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	2.0	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	1.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.3	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.1	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	1.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	1.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.8	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.8	PID TNF PATHWAY	TNF receptor signaling pathway

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.2	2.0	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	1.4	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
0.0	1.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.2	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	1.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	0.9	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.8	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.1	0.7	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	0.7	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels

Showing 1 to 10 of 34 entries

Results for mycn

Z-value: 1.24

Motif logo

Transcription factors associated with mycn

Activity-expression correlation:

Activity profile of mycn motif

Sorted Z-values of mycn motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: