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PRJNA195909:zebrafish embryo and larva development
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Results for mybl2b
Z-value: 1.93
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Transcription factors associated with mybl2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mybl2b | dr11_v1_chr11_+_1565806_1565806 | 0.88 | 1.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_43656125 Show fit | 4.95 |
ENSDART00000136392
ENSDART00000192805 ENSDART00000181960 |
si:ch211-263m18.4 si:dkey-229d11.5 |
|
| chr10_-_26202766 Show fit | 4.78 |
ENSDART00000136393
|
FH2 domain containing 3 |
|
| chr2_+_6253246 Show fit | 4.46 |
ENSDART00000058256
ENSDART00000076700 |
zona pellucida glycoprotein 3b |
|
| chr2_+_307665 Show fit | 3.52 |
ENSDART00000082083
|
zgc:113452 |
|
| chr19_+_43579786 Show fit | 2.72 |
ENSDART00000138404
|
si:ch211-199g17.2 |
|
| chr8_-_1730686 Show fit | 2.54 |
ENSDART00000183802
|
|
|
| chr25_-_16552135 Show fit | 2.44 |
ENSDART00000125836
|
si:ch211-266k8.4 |
|
| chr1_-_354115 Show fit | 2.40 |
ENSDART00000141590
ENSDART00000098627 |
protein S |
|
| chr24_-_21150100 Show fit | 2.37 |
ENSDART00000154249
ENSDART00000193256 |
GRAM domain containing 1c |
|
| chr16_-_41714988 Show fit | 2.20 |
ENSDART00000138798
|
centrosomal protein 85 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mybl2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.5 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 4.5 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 3.5 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.1 | 3.5 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 3.2 | GO:0048538 | thymus development(GO:0048538) |
| 0.1 | 3.1 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.1 | 3.0 | GO:0032924 | activin receptor signaling pathway(GO:0032924) |
| 0.0 | 3.0 | GO:0006869 | lipid transport(GO:0006869) |
| 0.1 | 2.7 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.1 | 2.7 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process(GO:0015012) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.9 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.2 | 3.0 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 2.7 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 2.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 2.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 2.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 2.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 1.9 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 1.9 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 1.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 0.4 | 4.5 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 4.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 3.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 2.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 2.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.5 | 2.1 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.3 | 2.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 2.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 2.0 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 1.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 0.9 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.8 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 1.5 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 1.3 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.2 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 1.1 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |