ISMARA results: myb+mybl1

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PRJNA195909:zebrafish embryo and larva development

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Results for myb+mybl1

Z-value: 2.11

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Transcription factors associated with myb+mybl1

Gene Symbol	Gene ID	Gene Info
mybl1 NCBI UniProt	ENSDARG00000030999	v-myb avian myeloblastosis viral oncogene homolog-like 1
myb NCBI UniProt	ENSDARG00000053666	v-myb avian myeloblastosis viral oncogene homolog
myb NCBI UniProt	ENSDARG00000114024	v-myb avian myeloblastosis viral oncogene homolog

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
myb	dr11_v1_chr23_+_31815423_31815492	-0.89	1.5e-03	Click!
mybl1	dr11_v1_chr24_+_23791758_23791839	-0.77	1.5e-02	Click!

Activity profile of myb+mybl1 motif

Sorted Z-values of myb+mybl1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_50685862 Show fit	3.62	ENSDART00000134146	mtss1 NCBI UniProt Show fit	metastasis suppressor 1
chr14_+_15155684 Show fit	3.14	ENSDART00000167966	zgc:158852 NCBI UniProt Show fit	zgc:158852
chr19_-_27827744 Show fit	2.85	ENSDART00000181620	papd7 NCBI UniProt Show fit	PAP associated domain containing 7
chr8_+_23034718 Show fit	2.82	ENSDART00000184512	ythdf1 NCBI UniProt Show fit	YTH N(6)-methyladenosine RNA binding protein 1
chr12_-_10508952 Show fit	2.71	ENSDART00000152806	zgc:152977 NCBI UniProt Show fit	zgc:152977
chr22_-_25612680 Show fit	2.67	ENSDART00000114167	si:ch211-12h2.8 NCBI UniProt Show fit	si:ch211-12h2.8
chr19_+_10661520 Show fit	2.61	ENSDART00000091813 ENSDART00000165653	ago3b NCBI UniProt Show fit	argonaute RISC catalytic component 3b
chr5_+_20257225 Show fit	2.15	ENSDART00000127919	ssh1a NCBI UniProt Show fit	slingshot protein phosphatase 1a
chr10_+_11038192 Show fit	2.13	ENSDART00000047954	ugcg NCBI UniProt Show fit	UDP-glucose ceramide glucosyltransferase
chr16_-_27566552 Show fit	2.09	ENSDART00000142102	zgc:153215 NCBI UniProt Show fit	zgc:153215

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of myb+mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.1	4.3	GO:0036297	interstrand cross-link repair(GO:0036297)
0.3	3.8	GO:0050779	RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.7	3.5	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	3.1	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.6	3.0	GO:0071908	determination of intestine left/right asymmetry(GO:0071908)
0.3	3.0	GO:0016246	RNA interference(GO:0016246)
0.3	2.9	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.1	2.8	GO:0006998	nuclear envelope organization(GO:0006998)
0.1	2.7	GO:0018345	protein palmitoylation(GO:0018345)

Showing 1 to 10 of 150 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.6	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1	2.7	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	2.7	GO:0043596	nuclear replication fork(GO:0043596)
0.4	2.5	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	2.3	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.4	2.2	GO:0031415	NatA complex(GO:0031415)
0.1	2.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.5	2.0	GO:0043073	germ cell nucleus(GO:0043073)
0.1	2.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.1	2.0	GO:0035861	site of double-strand break(GO:0035861)

Showing 1 to 10 of 78 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	5.4	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.3	4.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.6	3.8	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	3.8	GO:0046982	protein heterodimerization activity(GO:0046982)
0.4	3.6	GO:0035198	miRNA binding(GO:0035198)
0.0	3.5	GO:0000287	magnesium ion binding(GO:0000287)
0.0	3.1	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	3.0	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1	2.9	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	3.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	2.7	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	2.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	2.2	PID AURORA A PATHWAY	Aurora A signaling
0.1	2.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	2.1	PID BCR 5PATHWAY	BCR signaling pathway
0.1	2.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	2.0	PID P73PATHWAY	p73 transcription factor network
0.1	1.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.2	2.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	2.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	1.8	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	1.7	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	1.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.4	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.1	1.3	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.2	1.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	1.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK

Showing 1 to 10 of 41 entries

Results for myb+mybl1

Z-value: 2.11

Motif logo

Transcription factors associated with myb+mybl1

Activity-expression correlation:

Activity profile of myb+mybl1 motif

Sorted Z-values of myb+mybl1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of myb+mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: