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PRJNA195909:zebrafish embryo and larva development
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Results for meis3
Z-value: 1.27
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Transcription factors associated with meis3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| meis3 | dr11_v1_chr15_-_6863317_6863317 | 0.57 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_22310919 Show fit | 2.48 |
ENSDART00000108719
|
crystallin, gamma M2d10 |
|
| chr16_-_16152199 Show fit | 2.33 |
ENSDART00000012718
|
fatty acid binding protein 11b |
|
| chr10_-_39011514 Show fit | 2.30 |
ENSDART00000075123
|
Purkinje cell protein 4a |
|
| chr9_-_22205682 Show fit | 2.22 |
ENSDART00000101869
|
crystallin, gamma M2d12 |
|
| chr9_-_22232902 Show fit | 2.16 |
ENSDART00000101845
|
crystallin, gamma M2d5 |
|
| chr9_-_22240052 Show fit | 2.10 |
ENSDART00000111109
|
crystallin, gamma M2d9 |
|
| chr23_+_23658474 Show fit | 2.04 |
ENSDART00000162838
|
agrin |
|
| chr1_-_26026956 Show fit | 1.99 |
ENSDART00000102346
|
si:ch211-145b13.6 |
|
| chr6_-_14146979 Show fit | 1.98 |
ENSDART00000089564
|
calcium channel, voltage-dependent, beta 4b subunit |
|
| chr1_-_40911332 Show fit | 1.91 |
ENSDART00000027463
|
H6 family homeobox 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of meis3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.7 | 2.0 | GO:1902571 | regulation of serine-type peptidase activity(GO:1902571) |
| 0.2 | 2.0 | GO:0018120 | peptidyl-arginine ADP-ribosylation(GO:0018120) |
| 0.0 | 2.0 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.2 | 1.9 | GO:1900052 | regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052) |
| 0.6 | 1.7 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.3 | 1.6 | GO:0007405 | neuroblast proliferation(GO:0007405) |
| 0.0 | 1.6 | GO:1990266 | neutrophil migration(GO:1990266) |
| 0.4 | 1.5 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.0 | 1.5 | GO:0071466 | cellular response to xenobiotic stimulus(GO:0071466) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 1.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.4 | 1.2 | GO:0043614 | multi-eIF complex(GO:0043614) |
| 0.0 | 1.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 1.0 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 0.8 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 2.0 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 2.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 2.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 2.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 1.7 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.2 | 1.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 1.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 1.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757) |
| 0.2 | 1.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.4 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.1 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.6 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |