ISMARA results: meis2a+meis2b_FO834857.1

Project

PRJNA195909:zebrafish embryo and larva development

Navigation

Downloads

Results for meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Z-value: 1.94

Motif logo

Transcription factors associated with meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Gene Symbol	Gene ID	Gene Info
meis2b NCBI UniProt	ENSDARG00000077840	Meis homeobox 2a
meis2a NCBI UniProt	ENSDARG00000098240	Meis homeobox 2a
FO834857.1 NCBI UniProt	ENSDARG00000112895	homeobox protein TGIF2-like
pknox1.1 NCBI UniProt	ENSDARG00000018765	pbx/knotted 1 homeobox 1.1
pknox1.2 NCBI UniProt	ENSDARG00000036542	pbx/knotted 1 homeobox 1.2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
meis2b	dr11_v1_chr20_-_10120442_10120442	-0.90	1.1e-03	Click!
FO834857.1	dr11_v1_chr6_-_1814457_1814457	0.85	4.0e-03	Click!
meis2a	dr11_v1_chr17_+_52822831_52822831	-0.59	9.7e-02	Click!
pknox1.1	dr11_v1_chr9_+_19529951_19529951	0.53	1.4e-01	Click!
pknox1.2	dr11_v1_chr1_-_46984142_46984142	-0.33	3.9e-01	Click!

Activity profile of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Sorted Z-values of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_25959940 Show fit	3.72	ENSDART00000143011 ENSDART00000140626	si:dkey-72l14.4 NCBI UniProt Show fit	si:dkey-72l14.4
chr17_-_36860988 Show fit	3.29	ENSDART00000154981	senp6b NCBI UniProt Show fit	SUMO1/sentrin specific peptidase 6b
chr8_-_32385989 Show fit	3.08	ENSDART00000143716 ENSDART00000098850	lipg NCBI UniProt Show fit	lipase, endothelial
chr14_-_41468892 Show fit	2.96	ENSDART00000173099 ENSDART00000003170	mid1ip1l NCBI UniProt Show fit	MID1 interacting protein 1, like
chr12_-_48168135 Show fit	2.77	ENSDART00000186624	pald1a NCBI UniProt Show fit	phosphatase domain containing, paladin 1a
chr14_-_6402769 Show fit	2.77	ENSDART00000121552	slc44a1b NCBI UniProt Show fit	solute carrier family 44 (choline transporter), member 1b
chr6_+_49052741 Show fit	2.66	ENSDART00000011876	sycp1 NCBI UniProt Show fit	synaptonemal complex protein 1
chr22_-_37834312 Show fit	2.56	ENSDART00000076128	ppp1r2 NCBI UniProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 2
chr3_+_7771420 Show fit	2.55	ENSDART00000156809 ENSDART00000156309	hook2 NCBI UniProt Show fit	hook microtubule-tethering protein 2
chr16_+_50434668 Show fit	2.53	ENSDART00000193500	IGLON5 NCBI UniProt Show fit	zgc:110372

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.7	GO:0032418	lysosome localization(GO:0032418)
0.0	3.7	GO:0000122	negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.2	3.5	GO:0019433	triglyceride catabolic process(GO:0019433)
0.1	3.5	GO:0006405	RNA export from nucleus(GO:0006405)
0.0	3.5	GO:0030837	negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1	3.4	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.8	3.3	GO:0090230	regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.1	3.3	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.1	3.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.3	2.8	GO:0038007	netrin-activated signaling pathway(GO:0038007)

Showing 1 to 10 of 208 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.7	GO:0002102	podosome(GO:0002102)
0.1	3.5	GO:0005643	nuclear pore(GO:0005643)
0.2	3.4	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	3.0	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.7	2.7	GO:0043073	germ cell nucleus(GO:0043073)
0.5	2.7	GO:0034657	GID complex(GO:0034657)
0.1	2.6	GO:0005844	polysome(GO:0005844)
0.1	2.5	GO:0035102	PRC1 complex(GO:0035102)
0.0	2.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	2.3	GO:0005776	autophagosome(GO:0005776)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.5	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	6.2	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	5.8	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	5.7	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	4.0	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.0	3.8	GO:0008017	microtubule binding(GO:0008017)
0.1	3.7	GO:0017124	SH3 domain binding(GO:0017124)
0.1	3.6	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.5	3.4	GO:0000995	transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.4	3.3	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)

Showing 1 to 10 of 158 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	3.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	2.2	PID BCR 5PATHWAY	BCR signaling pathway
0.1	2.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	1.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	1.8	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	1.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	1.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	1.4	PID ATR PATHWAY	ATR signaling pathway
0.2	1.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	4.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1	3.7	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1	3.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	3.1	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	2.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	2.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	1.8	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	1.6	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	1.5	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling

Showing 1 to 10 of 49 entries

Results for meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Z-value: 1.94

Motif logo

Transcription factors associated with meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Activity-expression correlation:

Activity profile of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Sorted Z-values of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: