ISMARA results: meis1a+meis1b

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PRJNA195909:zebrafish embryo and larva development

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Results for meis1a+meis1b

Z-value: 1.65

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Transcription factors associated with meis1a+meis1b

Gene Symbol	Gene ID	Gene Info
meis1a NCBI UniProt	ENSDARG00000002937	Meis homeobox 1 a
meis1b NCBI UniProt	ENSDARG00000012078	Meis homeobox 1 b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
meis1b	dr11_v1_chr13_-_5568928_5568928	-0.72	3.0e-02	Click!
meis1a	dr11_v1_chr1_+_51496862_51496862	-0.23	5.5e-01	Click!

Activity profile of meis1a+meis1b motif

Sorted Z-values of meis1a+meis1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_27855346 Show fit	2.71	ENSDART00000175159 ENSDART00000192645	buc NCBI UniProt Show fit	bucky ball
chr18_+_1703984 Show fit	2.37	ENSDART00000114010	slitrk3a NCBI UniProt Show fit	SLIT and NTRK-like family, member 3a
chr19_+_33850705 Show fit	2.25	ENSDART00000160356	pex1 NCBI UniProt Show fit	peroxisomal biogenesis factor 1
chr5_+_55984270 Show fit	2.15	ENSDART00000047358 ENSDART00000138191	fkbp6 NCBI UniProt Show fit	FK506 binding protein 6
chr17_+_47174525 Show fit	1.85	ENSDART00000156831	CLIP4 NCBI UniProt Show fit	si:dkeyp-47f9.4
chr3_+_29082267 Show fit	1.73	ENSDART00000145615	cacna1i NCBI UniProt Show fit	calcium channel, voltage-dependent, T type, alpha 1I subunit
chr5_-_67661102 Show fit	1.72	ENSDART00000013605	zbtb20 NCBI UniProt Show fit	zinc finger and BTB domain containing 20
chr12_+_46543572 Show fit	1.69	ENSDART00000167510	hid1b NCBI UniProt Show fit	HID1 domain containing b
chr17_+_13031497 Show fit	1.67	ENSDART00000115208	fbxo33 NCBI UniProt Show fit	F-box protein 33
chr6_+_51713076 Show fit	1.62	ENSDART00000146281	ripor3 NCBI UniProt Show fit	RIPOR family member 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of meis1a+meis1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.0	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	3.2	GO:0090630	activation of GTPase activity(GO:0090630)
1.0	2.9	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.0	2.9	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.5	2.7	GO:0060832	oocyte animal/vegetal axis specification(GO:0060832)
0.1	2.5	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	2.3	GO:0015718	monocarboxylic acid transport(GO:0015718)
0.1	2.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.1	2.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	2.0	GO:0016579	protein deubiquitination(GO:0016579)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.8	GO:0005769	early endosome(GO:0005769)
0.1	4.0	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	3.2	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.3	2.7	GO:0032019	mitochondrial cloud(GO:0032019)
0.0	2.1	GO:0042383	sarcolemma(GO:0042383)
0.0	1.9	GO:0008021	synaptic vesicle(GO:0008021)
0.0	1.8	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	1.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	1.6	GO:0002116	semaphorin receptor complex(GO:0002116)
0.2	1.4	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Showing 1 to 10 of 73 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:1901981	phosphatidylinositol phosphate binding(GO:1901981)
0.0	3.0	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	2.9	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	2.7	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1	2.5	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.2	2.3	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	2.3	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	2.0	GO:0000149	SNARE binding(GO:0000149)
0.0	1.9	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.3	1.8	GO:0048156	tau protein binding(GO:0048156)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	2.1	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	1.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	1.7	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	1.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	1.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	1.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.1	0.9	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.7	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	2.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	1.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	1.6	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	1.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.5	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.1	1.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	1.4	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	1.2	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	1.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification

Showing 1 to 10 of 37 entries

Results for meis1a+meis1b

Z-value: 1.65

Motif logo

Transcription factors associated with meis1a+meis1b

Activity-expression correlation:

Activity profile of meis1a+meis1b motif

Sorted Z-values of meis1a+meis1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of meis1a+meis1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: