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PRJNA195909:zebrafish embryo and larva development
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Results for mef2d
Z-value: 2.91
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Transcription factors associated with mef2d
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mef2d | dr11_v1_chr16_-_29194517_29194517 | -0.37 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_7546259 Show fit | 10.16 |
ENSDART00000015732
|
myosin, light polypeptide 3, skeletal muscle |
|
| chr3_-_61205711 Show fit | 9.04 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr12_-_17712393 Show fit | 6.79 |
ENSDART00000143534
ENSDART00000010144 |
parvalbumin 2 |
|
| chr15_-_23645810 Show fit | 6.24 |
ENSDART00000168845
|
creatine kinase, muscle b |
|
| chr11_+_11201096 Show fit | 6.17 |
ENSDART00000171916
ENSDART00000171521 ENSDART00000087105 ENSDART00000159603 |
myomesin 2a |
|
| chr23_+_20110086 Show fit | 6.10 |
ENSDART00000054664
|
troponin C type 1b (slow) |
|
| chr25_+_29160102 Show fit | 5.40 |
ENSDART00000162854
|
pyruvate kinase M1/2b |
|
| chr24_-_24038800 Show fit | 5.12 |
ENSDART00000080549
|
lysozyme |
|
| chr9_-_33107237 Show fit | 5.03 |
ENSDART00000013918
|
calsequestrin 2 |
|
| chr5_-_72125551 Show fit | 4.88 |
ENSDART00000149412
|
SET and MYND domain containing 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of mef2d
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.1 | GO:0006599 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.1 | 7.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.5 | 7.6 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.2 | 7.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.5 | 7.0 | GO:0045851 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
| 1.2 | 6.0 | GO:0010332 | response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480) |
| 0.1 | 5.8 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.7 | 5.3 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 1.3 | 5.0 | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882) |
| 0.5 | 4.9 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0005576 | extracellular region(GO:0005576) |
| 0.8 | 16.8 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 13.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 11.8 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.7 | 7.0 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.7 | 5.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.7 | 5.0 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.5 | 4.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 4.1 | GO:0008305 | integrin complex(GO:0008305) |
| 0.3 | 4.0 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 39.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 27.0 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.0 | 13.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 9.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.7 | 9.1 | GO:0016775 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.3 | 8.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.5 | 7.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.6 | 6.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.8 | 6.4 | GO:0015168 | glycerol transmembrane transporter activity(GO:0015168) |
| 0.0 | 6.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 4.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 2.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.5 | 3.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 3.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 2.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 2.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.7 | 2.1 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 2.1 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |