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PRJNA195909:zebrafish embryo and larva development
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Results for mef2b
Z-value: 1.32
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Transcription factors associated with mef2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mef2b | dr11_v1_chr22_+_18188045_18188045 | 0.46 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_61205711 Show fit | 5.10 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr3_-_32818607 Show fit | 4.18 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr25_+_29160102 Show fit | 3.38 |
ENSDART00000162854
|
pyruvate kinase M1/2b |
|
| chr11_+_11201096 Show fit | 2.85 |
ENSDART00000171916
ENSDART00000171521 ENSDART00000087105 ENSDART00000159603 |
myomesin 2a |
|
| chr9_-_33107237 Show fit | 2.70 |
ENSDART00000013918
|
calsequestrin 2 |
|
| chr5_-_72125551 Show fit | 2.65 |
ENSDART00000149412
|
SET and MYND domain containing 1a |
|
| chr16_+_29663809 Show fit | 2.41 |
ENSDART00000191336
|
tropomodulin 4 (muscle) |
|
| chr6_-_42003780 Show fit | 2.39 |
ENSDART00000032527
|
caveolin 3 |
|
| chr5_+_51597677 Show fit | 2.31 |
ENSDART00000048210
ENSDART00000184797 |
creatine kinase, mitochondrial 2b (sarcomeric) |
|
| chr23_+_20110086 Show fit | 2.12 |
ENSDART00000054664
|
troponin C type 1b (slow) |
Network of associatons between targets according to the STRING database.
First level regulatory network of mef2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.3 | 3.8 | GO:0045851 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
| 0.7 | 2.7 | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882) |
| 0.3 | 2.6 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.3 | 2.4 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.3 | 2.4 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 0.2 | 2.4 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.2 | 2.3 | GO:0046314 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.3 | 2.1 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 0.2 | 2.0 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 4.5 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.4 | 3.8 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.4 | 2.7 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 2.4 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.3 | 2.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 1.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 1.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 1.5 | GO:0008305 | integrin complex(GO:0008305) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 4.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 4.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 3.8 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.6 | 3.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 2.6 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.6 | 2.4 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 2.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 2.3 | GO:0004111 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.3 | 2.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 1.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 1.1 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.9 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.1 | 0.8 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 0.5 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 0.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |