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PRJNA195909:zebrafish embryo and larva development
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Results for mef2aa+mef2ab
Z-value: 2.59
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Transcription factors associated with mef2aa+mef2ab
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mef2ab | dr11_v1_chr7_+_15677196_15677196 | 0.67 | 4.7e-02 | Click! |
| mef2aa | dr11_v1_chr18_+_23193820_23193820 | 0.48 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_61205711 Show fit | 7.32 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr9_-_22205682 Show fit | 5.36 |
ENSDART00000101869
|
crystallin, gamma M2d12 |
|
| chr3_+_32526263 Show fit | 4.95 |
ENSDART00000150897
|
si:ch73-367p23.2 |
|
| chr3_+_28939759 Show fit | 4.93 |
ENSDART00000141904
|
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1 |
|
| chr19_-_7450796 Show fit | 4.64 |
ENSDART00000104750
|
MLLT11, transcription factor 7 cofactor |
|
| chr12_-_26064105 Show fit | 4.56 |
ENSDART00000168825
|
LIM domain binding 3b |
|
| chr9_-_22188117 Show fit | 4.26 |
ENSDART00000132890
|
crystallin, gamma M2d17 |
|
| chr12_-_17712393 Show fit | 4.20 |
ENSDART00000143534
ENSDART00000010144 |
parvalbumin 2 |
|
| chr12_-_5120339 Show fit | 4.12 |
ENSDART00000168759
|
retinol binding protein 4, plasma |
|
| chr5_-_72125551 Show fit | 3.98 |
ENSDART00000149412
|
SET and MYND domain containing 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of mef2aa+mef2ab
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | GO:0061061 | muscle structure development(GO:0061061) |
| 0.1 | 9.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.4 | 8.8 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.3 | 4.8 | GO:0051452 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
| 0.1 | 4.7 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.9 | 4.6 | GO:0090199 | regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 4.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.6 | 4.1 | GO:0034633 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) |
| 0.1 | 3.5 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.2 | 3.1 | GO:0006599 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 8.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 7.7 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.3 | 6.8 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 6.5 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 5.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 5.1 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 4.8 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 3.9 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 3.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 12.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 8.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.7 | 7.2 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.2 | 6.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 4.8 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.6 | 4.1 | GO:0034632 | retinol transporter activity(GO:0034632) |
| 0.1 | 4.0 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 1.2 | 3.5 | GO:0031716 | calcitonin receptor binding(GO:0031716) |
| 0.1 | 3.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 2.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 2.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 1.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 2.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 1.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.6 | 1.7 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 1.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.3 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 1.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |