Project
PRJNA195909:zebrafish embryo and larva development
Navigation
Downloads
Results for mecp2
Z-value: 1.34
Motif logo
Transcription factors associated with mecp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mecp2 | dr11_v1_chr8_-_7637626_7637640 | 0.91 | 6.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_55758103 Show fit | 1.71 |
ENSDART00000185964
|
|
|
| chr9_-_32158288 Show fit | 1.53 |
ENSDART00000037182
|
ankyrin repeat domain 44 |
|
| chr5_-_825920 Show fit | 1.45 |
ENSDART00000126982
|
zgc:158463 |
|
| chr4_+_3438510 Show fit | 1.38 |
ENSDART00000155320
|
ataxin 7-like 1 |
|
| chr4_-_77561679 Show fit | 1.29 |
ENSDART00000180809
|
|
|
| chr11_+_42422371 Show fit | 1.29 |
ENSDART00000163780
|
DENN/MADD domain containing 6Aa |
|
| chr19_-_47587719 Show fit | 1.27 |
ENSDART00000111108
|
|
|
| chr19_-_27830818 Show fit | 1.27 |
ENSDART00000131767
|
PAP associated domain containing 7 |
|
| chr5_-_30382925 Show fit | 1.21 |
ENSDART00000125381
|
grass carp reovirus (GCRV)-induced gene 2o |
|
| chr17_-_27235797 Show fit | 1.21 |
ENSDART00000130080
|
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mecp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 1.8 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 1.4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 1.4 | GO:0031098 | stress-activated protein kinase signaling cascade(GO:0031098) |
| 0.1 | 1.3 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.3 | 1.0 | GO:0060283 | negative regulation of oocyte development(GO:0060283) |
| 0.2 | 1.0 | GO:0016267 | O-glycan processing, core 1(GO:0016267) |
| 0.2 | 1.0 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.1 | 1.0 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 1.0 | GO:0033339 | pectoral fin development(GO:0033339) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.1 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.1 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.2 | 1.0 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 1.0 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.9 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.8 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 0.7 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.8 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 1.4 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 1.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 1.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 1.0 | GO:0048531 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.2 | 1.0 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.1 | 1.0 | GO:0070698 | type I activin receptor binding(GO:0070698) |
| 0.0 | 1.0 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 1.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 0.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 0.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 0.9 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 0.9 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.1 | 0.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 0.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 0.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |