ISMARA results: mecom

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PRJNA195909:zebrafish embryo and larva development

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Results for mecom

Z-value: 1.86

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Transcription factors associated with mecom

Gene Symbol	Gene ID	Gene Info
mecom NCBI UniProt	ENSDARG00000060808	MDS1 and EVI1 complex locus

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mecom	dr11_v1_chr15_-_35406564_35406564	0.95	1.2e-04	Click!

Activity profile of mecom motif

Sorted Z-values of mecom motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_61203203 Show fit	5.40	ENSDART00000171787	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr3_-_32817274 Show fit	4.65	ENSDART00000142582	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr17_-_125091 Show fit	4.22	ENSDART00000158825	actc1b NCBI UniProt Show fit	actin, alpha, cardiac muscle 1b
chr16_-_41990421 Show fit	3.66	ENSDART00000055921	pycard NCBI UniProt Show fit	PYD and CARD domain containing
chr21_+_6556635 Show fit	3.56	ENSDART00000139598	col5a1 NCBI UniProt Show fit	procollagen, type V, alpha 1
chr7_-_8374950 Show fit	3.54	ENSDART00000057101	aep1 NCBI UniProt Show fit	aerolysin-like protein
chr10_-_22854758 Show fit	3.52	ENSDART00000079449	and3 NCBI UniProt Show fit	actinodin3
chr15_-_23647078 Show fit	3.24	ENSDART00000059366	ckmb NCBI UniProt Show fit	creatine kinase, muscle b
chr5_-_20195350 Show fit	3.09	ENSDART00000139675	dao.1 NCBI UniProt Show fit	D-amino-acid oxidase, tandem duplicate 1
chr13_+_13681681 Show fit	2.89	ENSDART00000057825	cfd NCBI UniProt Show fit	complement factor D (adipsin)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mecom

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.9	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	5.0	GO:0030199	collagen fibril organization(GO:0030199)
0.0	4.0	GO:0042742	defense response to bacterium(GO:0042742)
0.7	3.7	GO:0030299	intestinal cholesterol absorption(GO:0030299)
0.1	3.7	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.2	3.2	GO:0042396	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.8	3.1	GO:0055130	alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
1.0	2.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.5	2.8	GO:0035176	mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.3	2.7	GO:0018904	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)

Showing 1 to 10 of 99 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.7	GO:0005615	extracellular space(GO:0005615)
0.2	6.9	GO:0005861	troponin complex(GO:0005861)
0.1	4.9	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.3	4.2	GO:0005869	dynactin complex(GO:0005869)
0.0	4.1	GO:0030424	axon(GO:0030424)
0.9	3.7	GO:0061702	inflammasome complex(GO:0061702)
0.9	3.6	GO:0005588	collagen type V trimer(GO:0005588)
0.1	3.5	GO:0046930	pore complex(GO:0046930)
0.0	3.1	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.4	2.7	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)

Showing 1 to 10 of 38 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.6	GO:0008013	beta-catenin binding(GO:0008013)
0.0	5.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	4.0	GO:0008201	heparin binding(GO:0008201)
0.2	3.7	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
1.2	3.5	GO:0048030	disaccharide binding(GO:0048030)
0.2	3.2	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.8	3.1	GO:0003884	D-amino-acid oxidase activity(GO:0003884)
0.1	2.7	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	2.7	GO:0005178	integrin binding(GO:0005178)
0.5	2.6	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)

Showing 1 to 10 of 66 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	NABA COLLAGENS	Genes encoding collagen proteins
0.2	3.7	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	3.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	2.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	2.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.3	2.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	2.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.6	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	1.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	6.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	5.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	2.9	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	2.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	2.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3	2.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	1.4	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	1.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.2	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)

Showing 1 to 10 of 23 entries

Results for mecom

Z-value: 1.86

Motif logo

Transcription factors associated with mecom

Activity-expression correlation:

Activity profile of mecom motif

Sorted Z-values of mecom motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mecom

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: