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PRJNA195909:zebrafish embryo and larva development

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Results for mecom

Z-value: 1.86

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Transcription factors associated with mecom

Gene Symbol Gene ID Gene Info
ENSDARG00000060808 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mecomdr11_v1_chr15_-_35406564_354065640.951.2e-04Click!

Activity profile of mecom motif

Sorted Z-values of mecom motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_61203203 5.40 ENSDART00000171787
parvalbumin 1
chr3_-_32817274 4.65 ENSDART00000142582
myosin light chain, phosphorylatable, fast skeletal muscle a
chr17_-_125091 4.22 ENSDART00000158825
actin, alpha, cardiac muscle 1b
chr16_-_41990421 3.66 ENSDART00000055921
PYD and CARD domain containing
chr21_+_6556635 3.56 ENSDART00000139598
procollagen, type V, alpha 1
chr7_-_8374950 3.54 ENSDART00000057101
aerolysin-like protein
chr10_-_22854758 3.52 ENSDART00000079449
actinodin3
chr15_-_23647078 3.24 ENSDART00000059366
creatine kinase, muscle b
chr5_-_20195350 3.09 ENSDART00000139675
D-amino-acid oxidase, tandem duplicate 1
chr13_+_13681681 2.89 ENSDART00000057825
complement factor D (adipsin)
chr18_-_6633984 2.81 ENSDART00000185241
troponin I, skeletal, slow c
chr21_+_7582036 2.75 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr7_-_24364536 2.73 ENSDART00000064789
thioredoxin
chr13_-_33822550 2.72 ENSDART00000143703
fibronectin leucine rich transmembrane 3
chr22_-_17611742 2.61 ENSDART00000144031
glutathione peroxidase 4a
chr15_+_19838458 2.51 ENSDART00000101204
activated leukocyte cell adhesion molecule b
chr15_+_22311803 2.39 ENSDART00000150182
hepatic and glial cell adhesion molecule a
chr14_+_35691889 2.36 ENSDART00000074685
glycine receptor, beta b
chr23_+_20110086 2.33 ENSDART00000054664
troponin C type 1b (slow)
chr7_+_38750871 2.29 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
coagulation factor II (thrombin)
chr10_-_31782616 2.28 ENSDART00000128839
fasciculation and elongation protein zeta 1 (zygin I)
chr23_+_44745317 2.24 ENSDART00000165654
ATPase Na+/K+ transporting subunit beta 2a
chr25_+_18564266 2.03 ENSDART00000172338
caveolin 1
chr5_+_49744713 1.98 ENSDART00000133384
nuclear receptor subfamily 2, group F, member 1a
chr18_+_16246806 1.96 ENSDART00000142584
ALX homeobox 1
chr3_-_18575868 1.86 ENSDART00000122968
aquaporin 8b
chr20_+_26538137 1.84 ENSDART00000045397
syntaxin 11b, tandem duplicate 1
chr15_+_33991928 1.84 ENSDART00000170177
von Willebrand factor D and EGF domains
chr24_+_25069609 1.82 ENSDART00000115165
APC membrane recruitment protein 2
chr15_+_19646902 1.81 ENSDART00000179822
lens intrinsic membrane protein 2.3
chr14_+_33722950 1.80 ENSDART00000075312
apelin
chr2_-_20923864 1.73 ENSDART00000006870
prostaglandin-endoperoxide synthase 2a
chr25_+_18563476 1.72 ENSDART00000170841
caveolin 1
chr9_+_48455909 1.67 ENSDART00000167243
low density lipoprotein receptor-related protein 2a
chr3_+_23743139 1.67 ENSDART00000187409
homeobox B3a
chr13_+_10232695 1.65 ENSDART00000080805
SIX homeobox 2a
chr18_-_6634424 1.62 ENSDART00000062423
ENSDART00000179955
troponin I, skeletal, slow c
chr8_-_14179798 1.59 ENSDART00000040645
ENSDART00000146749
ras homolog gene family, member Aa
chr10_-_28761454 1.57 ENSDART00000129400
activated leukocyte cell adhesion molecule a
chr25_-_31629095 1.56 ENSDART00000170673
ENSDART00000166930
laminin, beta 1a
chr3_+_23742868 1.54 ENSDART00000153512
homeobox B3a
chr14_+_52563794 1.50 ENSDART00000168874
ribosomal protein L26
chr19_+_16222618 1.48 ENSDART00000137189
ENSDART00000169246
ENSDART00000190583
ENSDART00000189521
protein tyrosine phosphatase, receptor type, U, a
chr10_+_9159279 1.46 ENSDART00000064968
RasGEF domain family, member 1Bb
chr20_+_34845672 1.42 ENSDART00000128895
elastin microfibril interfacer 1a
chr7_-_17028015 1.40 ENSDART00000022441
developing brain homeobox 1a
chr11_-_3343463 1.40 ENSDART00000066177
tubulin, alpha 2
chr4_-_16353733 1.40 ENSDART00000186785
lumican
chr22_+_10752511 1.38 ENSDART00000081188
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr24_-_26304386 1.37 ENSDART00000175416
otospiralin
chr21_-_37733287 1.35 ENSDART00000157826
membrane protein, palmitoylated 1
chr6_-_39275793 1.34 ENSDART00000180477
ENSDART00000148531
Rho guanine nucleotide exchange factor (GEF) 25b
chr11_-_23219367 1.34 ENSDART00000003646
opticin
chr2_+_25816843 1.34 ENSDART00000078639
solute carrier family 2 (facilitated glucose transporter), member 2
chr20_-_34801181 1.34 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr21_-_15674802 1.33 ENSDART00000136666
matrix metallopeptidase 11b
chr22_+_10752787 1.33 ENSDART00000186542
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr2_+_29976419 1.29 ENSDART00000056748
engrailed homeobox 2b
chr6_+_8176486 1.26 ENSDART00000193308
nuclear factor, interleukin 3 regulated, member 5
chr9_+_2002701 1.25 ENSDART00000082329
even-skipped homeobox 2
chr6_-_31806345 1.25 ENSDART00000149369
si:dkey-209n16.2
chr8_+_34731982 1.24 ENSDART00000066050
4-hydroxyphenylpyruvate dioxygenase b
chr23_-_24682244 1.24 ENSDART00000104035
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr2_-_59145027 1.23 ENSDART00000128320

chr22_+_11535131 1.21 ENSDART00000113930
neuropeptide B
chr13_+_29771463 1.21 ENSDART00000134424
ENSDART00000138332
ENSDART00000134330
ENSDART00000160944
ENSDART00000076992
ENSDART00000160921
paired box 2a
chr8_-_38477817 1.21 ENSDART00000075989
inositol polyphosphate-5-phosphatase L
chr10_-_7988396 1.20 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr1_+_41588170 1.20 ENSDART00000139175
si:dkey-56e3.2
chr6_-_34008827 1.19 ENSDART00000191183
ENSDART00000003701
ENSDART00000192502
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr8_+_20880848 1.18 ENSDART00000134488
ENSDART00000138605
ENSDART00000192234
si:ch73-196i15.3
chr6_-_10964083 1.18 ENSDART00000181583
notum pectinacetylesterase 2
chr24_+_28525507 1.18 ENSDART00000191121
Rho GTPase activating protein 29a
chr17_-_42213822 1.17 ENSDART00000187904
ENSDART00000180029
NK2 homeobox 2a
chr24_+_23742690 1.17 ENSDART00000130162
transcription factor 24
chr16_+_11573471 1.17 ENSDART00000145858
si:dkey-11o1.2
chr17_-_30702411 1.17 ENSDART00000114358
zgc:194392
chr10_+_8767541 1.16 ENSDART00000170272
integrin, alpha 1
chr9_-_21904695 1.13 ENSDART00000134768
LIM domain 7a
chr23_+_9220436 1.13 ENSDART00000033663
ENSDART00000139870
ribosomal protein S21
chr16_-_42013858 1.13 ENSDART00000045403
ets variant 2
chr16_+_7662609 1.12 ENSDART00000184895
ENSDART00000149404
ENSDART00000081418
ENSDART00000081422
blood vessel epicardial substance
chr8_+_39511932 1.12 ENSDART00000113511
leucine zipper, putative tumor suppressor 1
chr21_+_5209716 1.11 ENSDART00000102539
ENSDART00000053148
ENSDART00000102536
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr6_-_7438584 1.10 ENSDART00000053776
FK506 binding protein 11
chr6_-_39765546 1.08 ENSDART00000185767
phosphofructokinase, muscle b
chr6_-_50203682 1.08 ENSDART00000083999
ENSDART00000143050
RALY heterogeneous nuclear ribonucleoprotein
chr9_-_9348058 1.07 ENSDART00000132257
zgc:113337
chr12_+_638435 1.07 ENSDART00000152508
si:ch211-176g6.1
chr1_-_21723329 1.07 ENSDART00000137138
si:ch211-134c9.2
chr8_-_28349859 1.06 ENSDART00000062671
tubulin, alpha 8 like
chr5_+_51026563 1.05 ENSDART00000050988
glucosaminyl (N-acetyl) transferase 4, core 2, a
chr5_+_4338874 1.05 ENSDART00000141866
spermidine/spermine N1-acetyltransferase 1a, duplicate 1
chr4_-_685412 1.04 ENSDART00000168167
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr4_+_41227127 1.03 ENSDART00000136445
si:dkey-16p19.5
chr10_+_22012389 1.03 ENSDART00000035188
Kv channel interacting protein 1 b
chr3_+_32443395 1.03 ENSDART00000188447
proline rich 12b
chr16_-_42014272 0.98 ENSDART00000180488
ets variant 2
chr17_-_12926456 0.97 ENSDART00000044126
INSM transcriptional repressor 2
chr9_-_23922778 0.96 ENSDART00000135769
collagen, type VI, alpha 3
chr8_-_52715911 0.95 ENSDART00000168241
tubulin, beta 2b
chr23_-_32304650 0.95 ENSDART00000143772
ENSDART00000085642
ENSDART00000188989
diacylglycerol kinase, alpha a
chr25_-_12923482 0.94 ENSDART00000161754

chr18_+_8346920 0.94 ENSDART00000083421
carnitine palmitoyltransferase 1B (muscle)
chr6_-_10963887 0.93 ENSDART00000151102
notum pectinacetylesterase 2
chr14_+_9462726 0.93 ENSDART00000063559
RELT-like 2
chr18_-_21271373 0.91 ENSDART00000060001
purine nucleoside phosphorylase 6
chr4_+_25220674 0.90 ENSDART00000066934
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr20_+_48803248 0.88 ENSDART00000164006
NK2 homeobox 4b
chr16_+_12836143 0.88 ENSDART00000067741
calcium channel, voltage-dependent, gamma subunit 6b
chr15_-_8517555 0.87 ENSDART00000140213
neuronal PAS domain protein 1
chr4_+_27131725 0.87 ENSDART00000013083
bromodomain containing 1a
chr25_+_25438165 0.86 ENSDART00000161369
si:ch211-103e16.5
chr20_+_1996202 0.86 ENSDART00000184143

chr7_-_38340674 0.84 ENSDART00000075782
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10a
chr9_-_1986014 0.84 ENSDART00000142842
homeobox D12a
chr21_+_41743493 0.82 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr2_-_10188598 0.81 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr19_+_19511394 0.80 ENSDART00000172410
JAZF zinc finger 1a
chr8_+_23485079 0.80 ENSDART00000026316
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr8_+_25079470 0.80 ENSDART00000000744
synaptophysin-like 2b
chr4_-_27398385 0.78 ENSDART00000142117
ENSDART00000150553
ENSDART00000182746
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr7_+_44445595 0.78 ENSDART00000108766
cadherin 5
chr23_+_42304602 0.77 ENSDART00000166004
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr8_+_27743550 0.77 ENSDART00000046004
wingless-type MMTV integration site family, member 2Bb
chr19_-_42557416 0.76 ENSDART00000163217
ENSDART00000128278
ENSDART00000162304
ENSDART00000166556
si:dkey-267n13.1
chr23_-_30781875 0.76 ENSDART00000114628
ENSDART00000180949
ENSDART00000191313
myelin transcription factor 1a
chr24_+_25471196 0.74 ENSDART00000066625
small muscle protein, X-linked
chr7_+_24114694 0.74 ENSDART00000127177
mitochondrial ribosomal protein L52
chr21_-_12119711 0.73 ENSDART00000131538
CUGBP, Elav-like family member 4
chr20_-_45807982 0.73 ENSDART00000074546
fermitin family member 1
chr9_+_30720048 0.72 ENSDART00000146115
Kruppel-like factor 12b
chr10_+_34394454 0.72 ENSDART00000110121
StAR-related lipid transfer (START) domain containing 13a
chr7_+_36552725 0.72 ENSDART00000173682
chromodomain helicase DNA binding protein 9
chr2_-_43168292 0.72 ENSDART00000132588
cAMP responsive element modulator a
chr9_+_10014817 0.71 ENSDART00000132065
neurexophilin 2a
chr22_-_17256573 0.70 ENSDART00000136119
ENSDART00000062891
nephrosis 2, idiopathic, steroid-resistant (podocin)
chr16_+_19014886 0.70 ENSDART00000079298
si:ch211-254p10.2
chr6_-_40697585 0.69 ENSDART00000113196
si:ch211-157b11.14
chr1_+_22002649 0.69 ENSDART00000141317
dynein, axonemal, heavy chain 6
chr22_-_29242347 0.68 ENSDART00000040761
parvalbumin 7
chr22_-_3152357 0.68 ENSDART00000170983
lamin B2
chr15_+_7054754 0.68 ENSDART00000149800
forkhead box L2a
chr21_-_22317920 0.67 ENSDART00000191083
ENSDART00000108701
glycerophosphodiester phosphodiesterase domain containing 4b
chr19_+_37620342 0.66 ENSDART00000158960
thrombospondin, type I, domain containing 7Aa
chr7_-_59054322 0.66 ENSDART00000165390
charged multivesicular body protein 5b
chr9_-_23990416 0.64 ENSDART00000113176
collagen, type VI, alpha 3
chr6_-_46861676 0.63 ENSDART00000188712
ENSDART00000190148
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr7_+_35238234 0.63 ENSDART00000178732
tubulin polymerization-promoting protein family member 3
chr21_-_40799404 0.63 ENSDART00000147405
ENSDART00000157512
zgc:162239
chr16_+_10972733 0.63 ENSDART00000049323
POU class 2 homeobox 2a
chr11_-_3865472 0.61 ENSDART00000161426
GATA binding protein 2a
chr23_-_45705525 0.60 ENSDART00000148959
endothelin receptor type Ab
chr5_-_5147041 0.60 ENSDART00000180236
LIM homeobox transcription factor 1, beta a
chr3_-_18792492 0.60 ENSDART00000134208
ENSDART00000034373
hydroxyacylglutathione hydrolase
chr3_+_24634481 0.60 ENSDART00000163080
si:dkey-68o6.8
chr1_+_33383971 0.60 ENSDART00000150043
dehydrogenase/reductase (SDR family) X-linked
chr1_+_31110817 0.59 ENSDART00000137863
eukaryotic translation elongation factor 1 alpha 1b
chr12_-_7854216 0.59 ENSDART00000149594
ankyrin 3b
chr9_+_10014514 0.59 ENSDART00000185590
neurexophilin 2a
chr9_-_19161982 0.59 ENSDART00000081878
POU class 1 homeobox 1
chr3_-_22228602 0.58 ENSDART00000017750
myosin, light chain 4, alkali; atrial, embryonic
chr15_+_6652396 0.58 ENSDART00000192813
ENSDART00000157678
NOP53 ribosome biogenesis factor
chr12_-_45197038 0.57 ENSDART00000016635
BRCA2 and CDKN1A interacting protein
chr22_-_15280638 0.57 ENSDART00000063008
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_1187928 0.57 ENSDART00000127252
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr2_-_51794472 0.56 ENSDART00000186652

chr9_+_1138323 0.54 ENSDART00000190352
ENSDART00000190387
solute carrier family 15 (oligopeptide transporter), member 1a
chr25_+_24616717 0.54 ENSDART00000089113
ankyrin repeat and BTB (POZ) domain containing 2b
chr14_-_3070613 0.54 ENSDART00000193729
ENSDART00000090196
solute carrier family 35, member A4
chr23_+_35969228 0.53 ENSDART00000179992
ENSDART00000184107
homeobox C10a
chr15_-_5172170 0.52 ENSDART00000062830
odorant receptor, family E, subfamily 126, member 5
chr19_+_27342479 0.52 ENSDART00000184687
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr15_-_8517376 0.52 ENSDART00000186289
neuronal PAS domain protein 1
chr13_+_3252950 0.52 ENSDART00000020671
peripherin 2b (retinal degeneration, slow)
chr11_-_37509001 0.50 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr18_-_17485419 0.50 ENSDART00000018764
forkhead box L1
chr13_-_12005429 0.49 ENSDART00000180302
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_5581487 0.49 ENSDART00000141943
spleen tyrosine kinase
chr2_-_1548330 0.49 ENSDART00000082155
ENSDART00000108481
ENSDART00000111272
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr25_+_25438322 0.48 ENSDART00000150364
si:ch211-103e16.5
chr14_-_32089117 0.48 ENSDART00000158014
si:ch211-69b22.5
chr5_-_10946232 0.48 ENSDART00000163139
ENSDART00000031265
reticulon 4 receptor
chr2_+_20410652 0.48 ENSDART00000185940
palmdelphin a
chr3_-_16289826 0.48 ENSDART00000131972
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr14_+_22591624 0.47 ENSDART00000108987
GDNF family receptor alpha 4b
chr16_-_14353567 0.47 ENSDART00000139859
integrin, alpha 10
chr5_+_20421539 0.46 ENSDART00000164499
selectin P ligand
chr18_-_28938912 0.46 ENSDART00000136201
si:ch211-174j14.2
chr4_-_12104421 0.46 ENSDART00000139561
mitochondrial ribosomal protein S33
chr8_-_53680653 0.46 ENSDART00000164739
wingless-type MMTV integration site family, member 5a
chr21_-_30658509 0.45 ENSDART00000139764
si:dkey-22f5.9
chr6_-_15101477 0.44 ENSDART00000187713
ENSDART00000124132
four and a half LIM domains 2b
chr25_+_26844028 0.43 ENSDART00000127274
ENSDART00000156179
semaphorin 7A
chr17_+_29348013 0.42 ENSDART00000188885
ENSDART00000192005
ENSDART00000190484
ENSDART00000188565
potassium channel tetramerization domain containing 3
chr8_+_2487250 0.42 ENSDART00000081325
dynein, light chain, LC8-type 1
chr16_+_14029283 0.41 ENSDART00000146165
ENSDART00000132075
RUN and SH3 domain containing 1
chr13_-_39830999 0.40 ENSDART00000115089
zgc:171482
chr4_+_63769987 0.40 ENSDART00000168878
zinc finger protein 1048
chr5_-_5147220 0.40 ENSDART00000187026
ENSDART00000162334
LIM homeobox transcription factor 1, beta a

Network of associatons between targets according to the STRING database.

First level regulatory network of mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 3.1 GO:0055130 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.7 3.7 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.5 2.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.5 2.8 GO:0035176 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.4 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.4 2.5 GO:0021885 forebrain cell migration(GO:0021885)
0.4 1.2 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 2.0 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.4 2.3 GO:0006953 acute-phase response(GO:0006953)
0.3 2.7 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 1.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.3 0.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.3 1.8 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.3 1.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.3 2.3 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.3 0.8 GO:0042941 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.3 1.0 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.3 1.6 GO:0055016 hypochord development(GO:0055016)
0.2 3.2 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 0.7 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 2.0 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.2 1.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.6 GO:1902893 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.2 1.2 GO:0021588 cerebellum formation(GO:0021588)
0.2 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.2 0.8 GO:0061010 gall bladder development(GO:0061010)
0.2 1.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.2 0.9 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2 0.5 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.2 2.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 1.4 GO:0070293 renal absorption(GO:0070293)
0.1 0.4 GO:0060907 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907)
0.1 5.0 GO:0030199 collagen fibril organization(GO:0030199)
0.1 6.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.8 GO:0001955 blood vessel maturation(GO:0001955) regulation of establishment of cell polarity(GO:2000114)
0.1 1.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.6 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 2.2 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 3.7 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 1.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.8 GO:0007398 ectoderm development(GO:0007398)
0.1 1.1 GO:0006735 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.7 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 1.0 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.2 GO:0071314 response to cocaine(GO:0042220) cellular response to alkaloid(GO:0071312) cellular response to cocaine(GO:0071314)
0.1 0.5 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.1 1.2 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.1 0.5 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.9 GO:0030878 thyroid gland development(GO:0030878)
0.1 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.9 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.2 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 1.8 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 2.4 GO:0030901 midbrain development(GO:0030901)
0.1 0.9 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.5 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 1.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 1.2 GO:0007631 feeding behavior(GO:0007631)
0.0 1.4 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.4 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.0 1.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.3 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 4.0 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.7 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.5 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 1.3 GO:1902749 regulation of cell cycle G2/M phase transition(GO:1902749)
0.0 2.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.3 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.6 GO:0010770 positive regulation of cell morphogenesis involved in differentiation(GO:0010770)
0.0 1.1 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.7 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 1.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 2.6 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.7 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0018199 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.0 0.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 1.4 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.8 GO:0021782 glial cell development(GO:0021782)
0.0 2.5 GO:0048793 pronephros development(GO:0048793)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.8 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.5 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0014823 response to activity(GO:0014823)
0.0 0.3 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0061702 inflammasome complex(GO:0061702)
0.9 3.6 GO:0005588 collagen type V trimer(GO:0005588)
0.4 2.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.3 4.2 GO:0005869 dynactin complex(GO:0005869)
0.2 2.2 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 6.9 GO:0005861 troponin complex(GO:0005861)
0.1 0.7 GO:0043034 costamere(GO:0043034)
0.1 1.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 3.5 GO:0046930 pore complex(GO:0046930)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 4.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.6 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.5 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 0.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 3.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0005771 multivesicular body(GO:0005771)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.1 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic cytoskeleton(GO:0099569)
0.0 4.1 GO:0030424 axon(GO:0030424)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 12.7 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0048030 disaccharide binding(GO:0048030)
0.8 3.1 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.6 1.8 GO:0031704 apelin receptor binding(GO:0031704)
0.5 2.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.5 2.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 1.2 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.3 2.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 3.2 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 3.7 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 1.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 1.9 GO:0015250 water channel activity(GO:0015250)
0.2 1.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 1.0 GO:0019809 spermidine binding(GO:0019809)
0.1 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.6 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1 1.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 1.2 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.1 0.9 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.1 2.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 2.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 2.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.6 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.2 GO:0016496 substance P receptor activity(GO:0016496)
0.1 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.1 GO:0030552 cAMP binding(GO:0030552)
0.1 0.9 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 2.7 GO:0005178 integrin binding(GO:0005178)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882) structural constituent of synapse(GO:0098918)
0.0 0.6 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 4.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.5 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 1.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.7 GO:0042562 hormone binding(GO:0042562)
0.0 2.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 5.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.0 1.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.8 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 1.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 3.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 5.2 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 0.8 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 2.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 3.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 2.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 2.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 2.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 1.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 5.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.1 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 0.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters