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PRJNA195909:zebrafish embryo and larva development
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Results for maza+mazb
Z-value: 4.32
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Transcription factors associated with maza+mazb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:ch211-166g5.4 | dr11_v1_chr12_-_3778848_3778848 | -0.69 | 4.2e-02 | Click! |
| maza | dr11_v1_chr3_-_21118969_21118969 | -0.56 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_44183451 Show fit | 8.83 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr2_-_44183613 Show fit | 8.77 |
ENSDART00000079596
|
cell adhesion molecule 3 |
|
| chr18_-_16123222 Show fit | 8.11 |
ENSDART00000061189
|
sarcospan (Kras oncogene-associated gene) |
|
| chr1_-_39943596 Show fit | 7.95 |
ENSDART00000149730
|
storkhead box 2a |
|
| chr21_+_26697536 Show fit | 6.53 |
ENSDART00000004109
|
guanine nucleotide binding protein (G protein), gamma 3 |
|
| chr10_-_44026369 Show fit | 6.50 |
ENSDART00000185456
|
crystallin, beta B1 |
|
| chr19_-_5254699 Show fit | 6.11 |
ENSDART00000081951
|
syntaxin 1B |
|
| chr14_-_9522364 Show fit | 5.75 |
ENSDART00000054689
|
atonal bHLH transcription factor 8 |
|
| chr3_-_61162750 Show fit | 5.58 |
ENSDART00000055064
|
parvalbumin 8 |
|
| chr7_+_36552725 Show fit | 5.25 |
ENSDART00000173682
|
chromodomain helicase DNA binding protein 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of maza+mazb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.6 | GO:0032616 | interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656) |
| 0.0 | 7.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 7.5 | GO:0021854 | hypothalamus development(GO:0021854) |
| 2.4 | 7.1 | GO:0006601 | creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601) |
| 0.1 | 6.5 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.2 | 6.3 | GO:0050654 | chondroitin sulfate proteoglycan metabolic process(GO:0050654) |
| 0.5 | 6.2 | GO:0050936 | xanthophore differentiation(GO:0050936) |
| 1.2 | 6.1 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 1.9 | 5.7 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.9 | 5.7 | GO:0035332 | positive regulation of hippo signaling(GO:0035332) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 47.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 11.8 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 9.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 9.0 | GO:0005764 | lysosome(GO:0005764) |
| 0.4 | 8.1 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.3 | 7.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.4 | 6.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.4 | 6.5 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.3 | 6.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 5.6 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 24.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 11.5 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 10.7 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 1.2 | 8.6 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.3 | 8.6 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.2 | 8.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 7.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 7.1 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.3 | 6.5 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 6.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 2.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 1.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 7.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 6.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.4 | 5.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.5 | 5.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 3.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 3.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 2.6 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.3 | 2.1 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 2.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |