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PRJNA195909:zebrafish embryo and larva development

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Results for mafb+mafba+nrl

Z-value: 1.80

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Transcription factors associated with mafb+mafba+nrl

Gene Symbol Gene ID Gene Info
ENSDARG00000017121 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
ENSDARG00000076520 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b)
ENSDARG00000100466 neural retina leucine zipper

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nrldr11_v1_chr20_+_661037_6610370.732.7e-02Click!
mafbadr11_v1_chr23_-_3408777_34087770.472.0e-01Click!
mafbdr11_v1_chr25_+_36674715_36674715-0.225.6e-01Click!

Activity profile of mafb+mafba+nrl motif

Sorted Z-values of mafb+mafba+nrl motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22318511 2.10 ENSDART00000129295
crystallin, gamma M2d2
chr9_-_22232902 1.70 ENSDART00000101845
crystallin, gamma M2d5
chr3_-_61185746 1.64 ENSDART00000028219
parvalbumin 4
chr1_+_44439661 1.53 ENSDART00000100309
crystallin, beta B1, like 2
chr3_-_61203203 1.32 ENSDART00000171787
parvalbumin 1
chr19_-_5345930 1.30 ENSDART00000066620
ENSDART00000151398
keratin type 1 c19e
chr6_-_60147517 1.24 ENSDART00000083453
solute carrier family 32 (GABA vesicular transporter), member 1
chr21_+_40106448 1.18 ENSDART00000100166
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr21_+_41697552 1.14 ENSDART00000169511
protein phosphatase 2, regulatory subunit B, beta b
chr7_-_26087807 1.13 ENSDART00000052989
acetylcholinesterase
chr19_-_5254699 1.09 ENSDART00000081951
syntaxin 1B
chr5_-_71722257 1.08 ENSDART00000013404
adenylate kinase 1
chr21_+_21374277 1.05 ENSDART00000079431
reticulon 2b
chr9_-_22240052 1.03 ENSDART00000111109
crystallin, gamma M2d9
chr14_+_49135264 1.02 ENSDART00000084119
si:ch1073-44g3.1
chr3_-_55147731 1.01 ENSDART00000155871
ENSDART00000109016
ENSDART00000122904
hemoglobin alpha embryonic-3
chr8_+_6954984 0.98 ENSDART00000145610
si:ch211-255g12.6
chr9_-_22147567 0.98 ENSDART00000110941
crystallin, gamma M2d14
chr9_-_22069364 0.98 ENSDART00000101938
crystallin, gamma M2b
chr11_-_1291012 0.96 ENSDART00000158390
ATPase plasma membrane Ca2+ transporting 2
chr24_-_26283359 0.96 ENSDART00000128618
actinodin1
chr7_-_24699985 0.93 ENSDART00000052802
calbindin 2b
chr17_+_9310259 0.90 ENSDART00000186158
ENSDART00000190329
neuronal PAS domain protein 3
chr1_-_59287410 0.89 ENSDART00000158011
ENSDART00000170580
collagen, type V, alpha 3b
chr9_-_296169 0.87 ENSDART00000165228
kinesin family member 5A, a
chr1_-_44434707 0.87 ENSDART00000110148
crystallin, beta A1, like 2
chr3_-_50443607 0.86 ENSDART00000074036
recoverin a
chr24_-_41312459 0.85 ENSDART00000041349
crystallin, gamma N2
chr10_-_26744131 0.81 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr19_+_58954 0.78 ENSDART00000162379
collagen, type XIV, alpha 1b
chr8_-_14052349 0.77 ENSDART00000135811
ATPase plasma membrane Ca2+ transporting 3a
chr3_+_40809892 0.75 ENSDART00000190803
actin related protein 2/3 complex, subunit 1B
chr9_+_30890549 0.73 ENSDART00000101070
dachshund d
chr22_-_10459880 0.71 ENSDART00000064801
osteoglycin
chr15_+_28096152 0.69 ENSDART00000100293
ENSDART00000140092
crystallin, beta B1, like 3
chr19_-_5332784 0.68 ENSDART00000010373
keratin, type 1, gene 19d
chr9_-_44295071 0.68 ENSDART00000011837
neuronal differentiation 1
chr21_-_22189719 0.68 ENSDART00000126908
ENSDART00000128780
olfactory marker protein b
chr4_+_26496489 0.67 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr3_-_55121125 0.67 ENSDART00000125092
hemoglobin, alpha embryonic 1
chr14_+_33458294 0.67 ENSDART00000075278
ATPase Na+/K+ transporting subunit beta 4
chr23_+_44614056 0.67 ENSDART00000188379
enolase 3, (beta, muscle)
chr21_+_17880511 0.67 ENSDART00000080481
retinoid X receptor, alpha a
chr1_+_36437585 0.66 ENSDART00000189182
POU class 4 homeobox 2
chr23_-_7799184 0.65 ENSDART00000190946
ENSDART00000165427
myelin transcription factor 1b
chr19_+_37925616 0.64 ENSDART00000148348
neurexophilin 1
chr17_-_12385308 0.64 ENSDART00000080927
synaptosomal-associated protein, 25b
chr12_+_42574148 0.64 ENSDART00000157855
early B cell factor 3a
chr3_+_20156956 0.64 ENSDART00000125281
nerve growth factor receptor a (TNFR superfamily, member 16)
chr24_+_17256793 0.62 ENSDART00000066764
COMM domain containing 3
chr9_-_7539297 0.61 ENSDART00000081550
ENSDART00000081553
desmin a
chr10_+_1052591 0.61 ENSDART00000123405
unc-5 netrin receptor C
chr20_-_54462551 0.61 ENSDART00000171769
ENSDART00000169692
Enah/Vasp-like b
chr13_+_3954540 0.60 ENSDART00000092646
leucine rich repeat containing 73
chr25_+_19999623 0.60 ENSDART00000026401
zgc:194665
chr3_-_32818607 0.60 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr19_+_23982466 0.60 ENSDART00000080673
synaptotagmin XIa
chr25_+_25124684 0.59 ENSDART00000167542
lactate dehydrogenase A4
chr2_+_6963296 0.58 ENSDART00000147146
discoidin domain receptor tyrosine kinase 2b
chr19_+_56351 0.58 ENSDART00000168334
collagen, type XIV, alpha 1b
chr17_-_122680 0.58 ENSDART00000066430
actin, alpha, cardiac muscle 1b
chr21_-_23475361 0.57 ENSDART00000156658
ENSDART00000157454
neural cell adhesion molecule 1a
chr17_-_37214196 0.57 ENSDART00000128715
kinesin family member 3Cb
chr5_-_21030934 0.57 ENSDART00000133461
ENSDART00000098667
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr22_-_651719 0.57 ENSDART00000148692
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr6_+_4539953 0.57 ENSDART00000025031
POU class 4 homeobox 1
chr10_+_20113830 0.56 ENSDART00000139722
dematin actin binding protein
chr5_-_28915130 0.55 ENSDART00000078592
neural proliferation, differentiation and control, 1b
chr4_+_19534833 0.55 ENSDART00000140028
leucine rich repeat containing 4.1
chr5_-_51619742 0.55 ENSDART00000188537
orthopedia homeobox b
chr22_+_38192568 0.55 ENSDART00000126323
ceruloplasmin
chr1_-_21344478 0.55 ENSDART00000077805
glutamate receptor, ionotropic, AMPA 2a
chr14_-_30366196 0.54 ENSDART00000007022
platelet-derived growth factor receptor-like
chr2_-_44720551 0.54 ENSDART00000146380
MAP6 domain containing 1
chr3_+_32557615 0.54 ENSDART00000151608
paired box 10
chr11_-_45185792 0.53 ENSDART00000171328
si:dkey-93h22.7
chr6_+_41255485 0.52 ENSDART00000042683
ENSDART00000186013
Ca2+-dependent activator protein for secretion b
chr7_+_50766094 0.52 ENSDART00000165037
si:ch73-380l10.2
chr21_-_34658266 0.52 ENSDART00000023038
dachshund a
chr25_-_3503164 0.52 ENSDART00000191477
ENSDART00000186345
ENSDART00000180199
si:ch211-272n13.7
chr19_-_28788466 0.52 ENSDART00000151793
SRY (sex determining region Y)-box 4a
chr1_-_43915423 0.52 ENSDART00000181915
ENSDART00000113673
secretory calcium-binding phosphoprotein 5
chr18_+_22793465 0.52 ENSDART00000149685
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr20_-_40717900 0.51 ENSDART00000181663
connexin 43
chr4_-_21851473 0.51 ENSDART00000019748
lin-7 homolog A (C. elegans)
chr5_-_70625697 0.51 ENSDART00000179538
ENSDART00000190540

chr21_-_45588720 0.51 ENSDART00000186642
ENSDART00000189531

chr12_-_314899 0.51 ENSDART00000066579
6-pyruvoyltetrahydropterin synthase
chr9_+_21407987 0.51 ENSDART00000145627
gap junction protein, alpha 3
chr16_+_1254390 0.51 ENSDART00000092627
ADAMTS like 4
chr1_-_40914752 0.50 ENSDART00000113087
H6 family homeobox 1
chr14_+_904850 0.50 ENSDART00000161847
si:ch73-208h1.1
chr6_-_13188667 0.50 ENSDART00000191654
ADAM metallopeptidase domain 23a
chr21_-_43015383 0.50 ENSDART00000065097
dihydropyrimidinase-like 3
chr14_-_17068511 0.50 ENSDART00000163766
paired-like homeobox 2bb
chr23_-_11870962 0.49 ENSDART00000143481
si:dkey-178k16.1
chr13_-_27038407 0.49 ENSDART00000146712
coiled-coil domain containing 85A
chr13_-_28308138 0.49 ENSDART00000045351
ladybird homeobox 1a
chr14_-_25599002 0.48 ENSDART00000040955
solute carrier family 25, member 48
chr18_+_39487486 0.48 ENSDART00000126978
acyl-CoA dehydrogenase long chain
chr6_-_57938043 0.48 ENSDART00000171073
TOX high mobility group box family member 2
chr16_+_27345383 0.47 ENSDART00000078250
ENSDART00000162857
nuclear receptor subfamily 4, group A, member 3
chr22_+_17359346 0.47 ENSDART00000145434
G protein-coupled receptor 52
chr19_+_233143 0.47 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr4_+_8797197 0.47 ENSDART00000158671
sulfotransferase family 4A, member 1
chr9_-_42696408 0.47 ENSDART00000144744
collagen, type V, alpha 2a
chr2_-_26001173 0.46 ENSDART00000010615
claudin 11a
chr22_-_31517300 0.46 ENSDART00000164799
solute carrier family 6 (neurotransmitter transporter), member 6b
chr9_+_14023386 0.46 ENSDART00000140199
ENSDART00000124267
si:ch211-67e16.4
chr19_+_49721 0.46 ENSDART00000160489
collagen, type XIV, alpha 1b
chr2_-_21625493 0.46 ENSDART00000137169
zgc:55781
chr3_-_57737913 0.46 ENSDART00000113309
zgc:112492
chr17_+_27140806 0.45 ENSDART00000044378
ribosomal protein S6 kinase a, polypeptide 1
chr13_+_3954715 0.45 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
leucine rich repeat containing 73
chr10_+_38775408 0.45 ENSDART00000125045
Down syndrome cell adhesion molecule a
chr24_+_24461558 0.45 ENSDART00000182424
basic helix-loop-helix family, member e22
chr20_+_48803248 0.45 ENSDART00000164006
NK2 homeobox 4b
chr13_+_24755049 0.44 ENSDART00000134102
collagen, type XVII, alpha 1b
chr13_-_25284379 0.44 ENSDART00000124167
vinculin a
chr7_+_39166460 0.44 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
midkine a
chr2_+_47754049 0.44 ENSDART00000098061
ENSDART00000074929
ENSDART00000074924
ENSDART00000149135
muscleblind-like splicing regulator 1
chr3_-_58455289 0.44 ENSDART00000052179
cerebellar degeneration-related protein 2a
chr5_-_33259079 0.44 ENSDART00000132223
interferon induced transmembrane protein 1
chr10_-_320153 0.43 ENSDART00000161493
v-akt murine thymoma viral oncogene homolog 2, like
chr14_-_52542928 0.43 ENSDART00000075749
protein phosphatase 2, regulatory subunit B, beta a
chr7_+_72882446 0.43 ENSDART00000131113
ENSDART00000174223
adhesion G protein-coupled receptor L3
chr15_+_45640906 0.43 ENSDART00000149361
ENSDART00000149079
S-antigen; retina and pineal gland (arrestin) b
chr5_-_65319387 0.42 ENSDART00000164649
collagen, type XXVII, alpha 1b
chr10_+_20108557 0.41 ENSDART00000142708
dematin actin binding protein
chr6_+_58543336 0.41 ENSDART00000157018
stathmin-like 3
chr25_+_33201727 0.41 ENSDART00000181051
ENSDART00000192378
zgc:171719
chr17_-_12336987 0.41 ENSDART00000172001
synaptosomal-associated protein, 25b
chr8_-_4596662 0.40 ENSDART00000138199
septin 5a
chr23_+_2669 0.40 ENSDART00000011146
twist3
chr23_-_3409140 0.40 ENSDART00000002309
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
chr19_+_41464870 0.40 ENSDART00000102778
distal-less homeobox 6a
chr23_-_26077038 0.40 ENSDART00000126299
GDP dissociation inhibitor 1
chr9_+_25096500 0.40 ENSDART00000135074
ENSDART00000180436
ENSDART00000108629
leucine-rich repeats and calponin homology (CH) domain containing 1
chr25_-_23052707 0.40 ENSDART00000024633
dual specificity phosphatase 8a
chr19_-_19871211 0.40 ENSDART00000170980
even-skipped homeobox 1
chr5_-_64168415 0.40 ENSDART00000048395
cardiac myosin light chain-1
chr14_+_52369262 0.40 ENSDART00000169352
ENSDART00000157833
insulin-like growth factor binding protein 7
chr22_-_600016 0.39 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr4_-_19028861 0.39 ENSDART00000166374
si:dkey-31f5.11
chr1_+_7679328 0.39 ENSDART00000163488
ENSDART00000190070
engrailed homeobox 1b
chr14_-_2050057 0.39 ENSDART00000112875
protocadherin beta 15
chr17_-_43286903 0.39 ENSDART00000176637
si:dkey-1f12.3
chr15_-_2954443 0.39 ENSDART00000161053
zgc:153184
chr4_-_27350820 0.39 ENSDART00000145806
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr5_-_12525441 0.38 ENSDART00000177490
ENSDART00000164190
kinase suppressor of ras 2
chr20_+_6773790 0.38 ENSDART00000169966
insulin-like growth factor binding protein 3
chr13_-_25284716 0.38 ENSDART00000039828
vinculin a
chr4_-_149334 0.38 ENSDART00000163280
TANK-binding kinase 1
chr7_-_38612230 0.37 ENSDART00000173678
C1q and TNF related 4
chr2_+_6926100 0.37 ENSDART00000153289
nitric oxide synthase 1 (neuronal) adaptor protein b
chr20_+_51312883 0.37 ENSDART00000084186
transmembrane protein 151Ba
chr19_+_32947910 0.37 ENSDART00000052091
ATPase H+ transporting V1 subunit C1b
chr20_+_52389858 0.37 ENSDART00000185863
ENSDART00000166651
Rho GTPase activating protein 39
chr2_-_24444838 0.36 ENSDART00000147885
ENSDART00000164720
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1a
chr12_-_29624638 0.36 ENSDART00000126744
neuregulin 3b
chr14_-_44841503 0.36 ENSDART00000179114
si:dkey-109l4.6
chr8_-_23416362 0.36 ENSDART00000063005
G protein-coupled receptor 173
chr19_+_40641338 0.36 ENSDART00000146468
VPS50 EARP/GARPII complex subunit
chr18_+_22793743 0.35 ENSDART00000150106
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr7_-_29200090 0.35 ENSDART00000173973
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr2_-_16217344 0.35 ENSDART00000152031
Rho guanine nucleotide exchange factor (GEF) 4
chr21_-_1625976 0.35 ENSDART00000066621
vitelline membrane outer layer 1 homolog b
chr6_-_24358732 0.35 ENSDART00000159595
epoxide hydrolase 4
chr14_-_52521460 0.35 ENSDART00000172110
G protein-coupled receptor 151
chr13_-_35051897 0.35 ENSDART00000129559
BTB (POZ) domain containing 3b
chr17_-_22021213 0.35 ENSDART00000078843
zmp:0000001102
chr9_+_39027312 0.35 ENSDART00000192258
ENSDART00000164407
carbamoyl-phosphate synthase 1, mitochondrial
chr9_+_39027123 0.35 ENSDART00000004742
carbamoyl-phosphate synthase 1, mitochondrial
chr7_+_58686860 0.35 ENSDART00000052332
proenkephalin b
chr20_-_34801181 0.35 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr20_-_35578435 0.35 ENSDART00000142444
adhesion G protein-coupled receptor F6
chr2_-_49985351 0.35 ENSDART00000145888
chemokine (C-C motif) receptor 12a
chr15_+_46386261 0.34 ENSDART00000191793
immunoglobulin superfamily member 11
chr20_+_21268795 0.34 ENSDART00000090016
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr8_-_44224198 0.34 ENSDART00000132015
syntaxin 2b
chr7_-_35710263 0.34 ENSDART00000043857
iroquois homeobox 5a
chr14_-_1454045 0.34 ENSDART00000161460
phosphoethanolamine methyltransferase
chr18_-_50842155 0.34 ENSDART00000174139
si:cabz01113374.3
chr20_-_31905968 0.33 ENSDART00000142806
syntaxin binding protein 5a (tomosyn)
chr15_+_3125136 0.33 ENSDART00000130968
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_-_38477235 0.33 ENSDART00000084355
zgc:165481
chr12_-_11570 0.33 ENSDART00000186179
shisa family member 6
chr18_+_50687702 0.33 ENSDART00000159877
purinergic receptor P2Y1
chr5_-_28029558 0.33 ENSDART00000078649
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr18_-_977075 0.33 ENSDART00000032392
dihydrodiol dehydrogenase (dimeric), like
chr8_+_53464216 0.33 ENSDART00000169514
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr8_-_44223899 0.33 ENSDART00000143020
syntaxin 2b
chr25_+_5044780 0.33 ENSDART00000153980
parvin, beta
chr22_-_38543630 0.33 ENSDART00000172029
si:ch211-126j24.1
chr3_-_30118856 0.33 ENSDART00000109953
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr8_+_53423408 0.33 ENSDART00000164792
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr9_-_23217196 0.32 ENSDART00000083567
kinesin family member 5C
chr23_-_30764319 0.32 ENSDART00000075918
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr21_+_244503 0.32 ENSDART00000162889
StAR-related lipid transfer (START) domain containing 4
chr8_-_44223473 0.32 ENSDART00000098525
syntaxin 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of mafb+mafba+nrl

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.2 0.9 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.2 1.1 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.2 0.9 GO:1990535 neuron projection maintenance(GO:1990535)
0.2 0.6 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.2 0.6 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.2 0.6 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.2 0.7 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 1.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 1.1 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.2 0.6 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.1 0.7 GO:0097272 ammonia homeostasis(GO:0097272)
0.1 0.8 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.1 0.4 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.5 GO:0003161 cardiac conduction system development(GO:0003161)
0.1 0.5 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 0.5 GO:0006844 acyl carnitine transport(GO:0006844)
0.1 1.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.3 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.3 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.5 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.3 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.1 0.4 GO:0021742 abducens nucleus development(GO:0021742)
0.1 0.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.6 GO:0021767 mammillary body development(GO:0021767)
0.1 0.5 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.0 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 11.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 0.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.2 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.1 0.7 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.1 0.3 GO:0035376 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 0.9 GO:0007608 sensory perception of smell(GO:0007608)
0.1 0.2 GO:0015824 proline transport(GO:0015824)
0.1 0.2 GO:0015874 norepinephrine transport(GO:0015874)
0.1 1.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.1 0.3 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 0.2 GO:0000256 allantoin catabolic process(GO:0000256) purine nucleobase catabolic process(GO:0006145)
0.1 0.3 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.1 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.2 GO:0035992 tendon formation(GO:0035992)
0.1 0.3 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.1 0.6 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.2 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.3 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 0.3 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703) inhibitory postsynaptic potential(GO:0060080)
0.1 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.6 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 0.2 GO:1903792 negative regulation of anion transport(GO:1903792)
0.1 0.5 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.2 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.9 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.5 GO:0048899 anterior lateral line development(GO:0048899)
0.0 0.3 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0090075 relaxation of muscle(GO:0090075)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.2 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) neuron fate determination(GO:0048664) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.2 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.1 GO:1901006 ubiquinone-6 metabolic process(GO:1901004) ubiquinone-6 biosynthetic process(GO:1901006)
0.0 0.3 GO:0043584 nose development(GO:0043584)
0.0 0.3 GO:0090179 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.1 GO:0010312 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.0 1.0 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.2 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
0.0 0.7 GO:0042670 retinal cone cell differentiation(GO:0042670)
0.0 0.5 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.2 GO:0016038 absorption of visible light(GO:0016038)
0.0 0.8 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.4 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.1 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.4 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.3 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.0 0.5 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.4 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.2 GO:0072319 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.0 0.2 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0007405 neuroblast proliferation(GO:0007405)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 1.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.3 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0032655 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.0 0.3 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 1.0 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.2 GO:0043901 negative regulation of multi-organism process(GO:0043901)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.7 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.5 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 0.1 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600) regulation of glucose import(GO:0046324)
0.0 0.3 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.3 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.5 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.2 GO:0035094 response to nicotine(GO:0035094)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0044785 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.0 0.2 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.0 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.3 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.1 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.1 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.9 GO:0030282 bone mineralization(GO:0030282)
0.0 0.6 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.0 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0 0.2 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 1.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0046498 S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.0 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.2 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 1.0 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.4 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 0.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.0 0.1 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.5 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.4 GO:1990745 EARP complex(GO:1990745)
0.1 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 2.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.1 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 0.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0016586 RSC complex(GO:0016586)
0.0 1.0 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 2.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0044306 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.2 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.2 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.3 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.0 GO:0042383 sarcolemma(GO:0042383)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.2 1.1 GO:0004104 cholinesterase activity(GO:0004104)
0.2 0.9 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 0.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 11.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.5 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.1 0.3 GO:0046978 TAP1 binding(GO:0046978)
0.1 0.3 GO:0047325 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.1 0.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.5 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 1.2 GO:0015295 solute:proton symporter activity(GO:0015295)
0.1 0.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.6 GO:0005035 death receptor activity(GO:0005035)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.2 GO:0005329 dopamine transmembrane transporter activity(GO:0005329) dopamine:sodium symporter activity(GO:0005330) norepinephrine transmembrane transporter activity(GO:0005333) norepinephrine:sodium symporter activity(GO:0005334)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.6 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.6 GO:0005522 profilin binding(GO:0005522)
0.1 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.2 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.0 3.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.4 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.4 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.9 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.1 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.7 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.0 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0019957 chemokine binding(GO:0019956) C-C chemokine binding(GO:0019957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.9 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.5 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.1 0.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.2 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 1.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction