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PRJNA195909:zebrafish embryo and larva development
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Results for mafb+mafba+nrl
Z-value: 1.80
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Transcription factors associated with mafb+mafba+nrl
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017121 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba | |
| ENSDARG00000076520 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b) | |
| ENSDARG00000100466 | neural retina leucine zipper |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nrl | dr11_v1_chr20_+_661037_661037 | 0.73 | 2.7e-02 | Click! |
| mafba | dr11_v1_chr23_-_3408777_3408777 | 0.47 | 2.0e-01 | Click! |
| mafb | dr11_v1_chr25_+_36674715_36674715 | -0.22 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_22318511 Show fit | 2.10 |
ENSDART00000129295
|
crystallin, gamma M2d2 |
|
| chr9_-_22232902 Show fit | 1.70 |
ENSDART00000101845
|
crystallin, gamma M2d5 |
|
| chr3_-_61185746 Show fit | 1.64 |
ENSDART00000028219
|
parvalbumin 4 |
|
| chr1_+_44439661 Show fit | 1.53 |
ENSDART00000100309
|
crystallin, beta B1, like 2 |
|
| chr3_-_61203203 Show fit | 1.32 |
ENSDART00000171787
|
parvalbumin 1 |
|
| chr19_-_5345930 Show fit | 1.30 |
ENSDART00000066620
ENSDART00000151398 |
keratin type 1 c19e |
|
| chr6_-_60147517 Show fit | 1.24 |
ENSDART00000083453
|
solute carrier family 32 (GABA vesicular transporter), member 1 |
|
| chr21_+_40106448 Show fit | 1.18 |
ENSDART00000100166
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
|
| chr21_+_41697552 Show fit | 1.14 |
ENSDART00000169511
|
protein phosphatase 2, regulatory subunit B, beta b |
|
| chr7_-_26087807 Show fit | 1.13 |
ENSDART00000052989
|
acetylcholinesterase |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafb+mafba+nrl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 1.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.3 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.2 | 1.2 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.3 | 1.1 | GO:1900619 | acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619) |
| 0.2 | 1.1 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.2 | 1.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 0.1 | 1.1 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.0 | 1.1 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 1.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 2.1 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 1.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.2 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 1.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.0 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 1.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 3.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 1.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.2 | 1.1 | GO:0004104 | cholinesterase activity(GO:0004104) |
| 0.1 | 1.1 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 1.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.2 | 0.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.9 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.2 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 1.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.1 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 0.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 0.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |