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PRJNA195909:zebrafish embryo and larva development
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Results for mafa+mafbb
Z-value: 1.90
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Transcription factors associated with mafa+mafbb
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000015890 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a) | |
| ENSDARG00000070542 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb | |
| ENSDARG00000099120 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mafa | dr11_v1_chr18_+_29402623_29402623 | 0.93 | 3.3e-04 | Click! |
| mafbb | dr11_v1_chr11_-_25384213_25384213 | 0.49 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_31277415 Show fit | 6.58 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr6_-_13783604 Show fit | 4.79 |
ENSDART00000149536
ENSDART00000041269 ENSDART00000150102 |
crystallin, beta A2a |
|
| chr5_-_67471375 Show fit | 4.62 |
ENSDART00000147009
|
si:dkey-251i10.2 |
|
| chr8_+_31435452 Show fit | 4.06 |
ENSDART00000145282
|
selenoprotein P |
|
| chr16_+_46294337 Show fit | 3.94 |
ENSDART00000040769
|
nuclear receptor subfamily 2, group F, member 5 |
|
| chr15_-_29388012 Show fit | 3.57 |
ENSDART00000115032
|
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b |
|
| chr2_-_24554416 Show fit | 3.52 |
ENSDART00000052061
|
calponin 2 |
|
| chr5_-_30615901 Show fit | 3.51 |
ENSDART00000147769
|
si:ch211-117m20.5 |
|
| chr19_+_7567763 Show fit | 3.44 |
ENSDART00000140411
|
S100 calcium binding protein A11 |
|
| chr18_+_22302635 Show fit | 3.44 |
ENSDART00000141051
|
capping protein regulator and myosin 1 linker 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafa+mafbb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.2 | 8.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 5.7 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.1 | 4.8 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.7 | 4.1 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.1 | 3.9 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.1 | 3.5 | GO:0043535 | regulation of blood vessel endothelial cell migration(GO:0043535) |
| 0.2 | 3.4 | GO:0030011 | maintenance of cell polarity(GO:0030011) |
| 0.8 | 3.2 | GO:0015840 | urea transport(GO:0015840) |
| 1.0 | 3.0 | GO:0006600 | creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.5 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 8.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 3.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 2.6 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.4 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 2.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 2.0 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 1.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 6.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.8 | 4.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 3.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
| 0.5 | 3.7 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 3.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 3.2 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 3.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 3.1 | GO:0072349 | modified amino acid transmembrane transporter activity(GO:0072349) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 3.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 2.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 2.3 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 2.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 2.3 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 2.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.3 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 0.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |