ISMARA results: lhx6-1

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PRJNA195909:zebrafish embryo and larva development

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Results for lhx6-1

Z-value: 1.91

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Transcription factors associated with lhx6-1

Gene Symbol	Gene ID	Gene Info
lhx6-1 NCBI UniProt	ENSDARG00000052165	si_ch211-236k19.2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
si:ch211-236k19.2	dr11_v1_chr5_-_64900552_64900552	0.70	3.6e-02	Click!

Activity profile of lhx6-1 motif

Sorted Z-values of lhx6-1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_+_1023839 Show fit	4.03	ENSDART00000082526	zgc:111976 NCBI UniProt Show fit	zgc:111976
chr2_-_38284648 Show fit	4.02	ENSDART00000148281 ENSDART00000132621	si:ch211-14a17.7 NCBI UniProt Show fit	si:ch211-14a17.7
chr12_-_33354409 Show fit	4.00	ENSDART00000178515	slc16a3 NCBI UniProt Show fit	solute carrier family 16 (monocarboxylate transporter), member 3
chr6_+_28208973 Show fit	3.76	ENSDART00000171216 ENSDART00000171377 ENSDART00000167389 ENSDART00000166988	LSM2 (1 of many) NCBI UniProt Show fit	si:ch73-14h10.2
chr2_+_6255434 Show fit	3.73	ENSDART00000139429	zp3b NCBI UniProt Show fit	zona pellucida glycoprotein 3b
chr10_-_34915886 Show fit	3.63	ENSDART00000141201 ENSDART00000002166	ccna1 NCBI UniProt Show fit	cyclin A1
chr10_-_34916208 Show fit	3.19	ENSDART00000187371	ccna1 NCBI UniProt Show fit	cyclin A1
chr12_-_33357655 Show fit	3.14	ENSDART00000066233 ENSDART00000148165	slc16a3 NCBI UniProt Show fit	solute carrier family 16 (monocarboxylate transporter), member 3
chr13_-_35808904 Show fit	2.90	ENSDART00000171667	map3k4 NCBI UniProt Show fit	mitogen-activated protein kinase kinase kinase 4
chr24_-_9979342 Show fit	2.79	ENSDART00000138576 ENSDART00000191206	zgc:171977 NCBI UniProt Show fit	zgc:171977

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6-1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.9	GO:0007339	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1	7.2	GO:1904029	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1	7.1	GO:0015718	monocarboxylic acid transport(GO:0015718)
0.0	4.5	GO:0006486	protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
1.3	4.0	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.2	3.4	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.2	3.1	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	2.6	GO:0016579	protein deubiquitination(GO:0016579)
0.6	2.3	GO:1905038	regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2	2.3	GO:0090481	pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	6.8	GO:0097124	cyclin A2-CDK2 complex(GO:0097124)
0.0	4.7	GO:0031012	extracellular matrix(GO:0031012)
0.1	4.1	GO:0016592	mediator complex(GO:0016592)
0.0	3.2	GO:0030173	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.3	2.4	GO:0005674	transcription factor TFIIF complex(GO:0005674)
0.6	2.3	GO:0035339	SPOTS complex(GO:0035339)
0.1	2.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	2.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	2.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	1.9	GO:0035097	histone methyltransferase complex(GO:0035097)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.9	GO:0032190	acrosin binding(GO:0032190)
0.6	7.1	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	6.8	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7	4.6	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	4.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.8	4.0	GO:0042809	vitamin D receptor binding(GO:0042809)
0.3	3.2	GO:0005459	UDP-galactose transmembrane transporter activity(GO:0005459)
0.2	2.9	GO:0008199	ferric iron binding(GO:0008199)
0.1	2.9	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	2.8	GO:0019904	protein domain specific binding(GO:0019904)

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	6.8	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	3.4	PID PLK1 PATHWAY	PLK1 signaling events
0.1	2.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	1.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	1.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.6	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	1.6	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	1.3	PID ATR PATHWAY	ATR signaling pathway
0.1	1.2	PID EPO PATHWAY	EPO signaling pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.4	6.8	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5	4.6	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	2.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.7	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	1.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	1.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	1.3	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling

Showing 1 to 10 of 31 entries

Results for lhx6-1

Z-value: 1.91

Motif logo

Transcription factors associated with lhx6-1

Activity-expression correlation:

Activity profile of lhx6-1 motif

Sorted Z-values of lhx6-1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6-1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: