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PRJNA195909:zebrafish embryo and larva development
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Results for lef1
Z-value: 2.48
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Transcription factors associated with lef1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| lef1 | dr11_v1_chr1_+_49814942_49814942 | -0.88 | 1.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23913943 Show fit | 6.09 |
ENSDART00000175404
ENSDART00000129525 |
apolipoprotein A-IV b, tandem duplicate 1 |
|
| chr16_-_45917322 Show fit | 5.51 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr16_-_45910050 Show fit | 5.09 |
ENSDART00000133213
|
antifreeze protein type IV |
|
| chr23_-_10175898 Show fit | 4.96 |
ENSDART00000146185
|
keratin 5 |
|
| chr18_-_23875370 Show fit | 4.30 |
ENSDART00000130163
|
nuclear receptor subfamily 2, group F, member 2 |
|
| chr15_-_3736149 Show fit | 3.89 |
ENSDART00000182986
|
lysophosphatidic acid receptor 6a |
|
| chr25_+_34576067 Show fit | 3.84 |
ENSDART00000157519
|
transient receptor potential cation channel, subfamily M, member 1b |
|
| chr9_-_33877476 Show fit | 3.77 |
ENSDART00000150035
ENSDART00000088441 ENSDART00000183210 |
si:ch73-147f11.1 |
|
| chr24_-_37568359 Show fit | 3.77 |
ENSDART00000056286
|
H1 histone family, member 0 |
|
| chr1_+_17376922 Show fit | 3.73 |
ENSDART00000145068
|
FAT atypical cadherin 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of lef1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.4 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.1 | 9.8 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.0 | 9.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.9 | 8.8 | GO:0060843 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.2 | 8.0 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.2 | 6.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 6.2 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.5 | 6.0 | GO:0003209 | cardiac atrium morphogenesis(GO:0003209) |
| 1.0 | 5.2 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.2 | 4.8 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 9.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 7.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 5.7 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 5.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 5.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 5.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.5 | 5.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 3.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.7 | GO:0016342 | catenin complex(GO:0016342) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 50.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 23.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.3 | 10.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.6 | 8.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.5 | 7.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 6.3 | GO:0008289 | lipid binding(GO:0008289) |
| 0.0 | 5.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 5.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.5 | 5.2 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.7 | 5.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 2.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 2.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.0 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 1.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 1.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 3.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.8 | 3.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.5 | 3.8 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 3.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 2.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 2.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 2.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 2.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 2.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |