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PRJNA195909:zebrafish embryo and larva development

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Results for klf15+si:ch211-117k10.3

Z-value: 0.56

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Transcription factors associated with klf15+si:ch211-117k10.3

Gene Symbol Gene ID Gene Info
si_ch211-117k10.3
ENSDARG00000090914 si_ch211-117k10.3
klf15
ENSDARG00000091127 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf15dr11_v1_chr23_-_35195908_35195908-0.854.0e-03Click!
si:ch211-117k10.3dr11_v1_chr11_-_38510469_385104690.452.2e-01Click!

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_8314028 1.61 ENSDART00000102739
si:ch211-145c1.1
si:ch211-145c1.1
chr14_+_34495216 1.13 ENSDART00000147756
wnt8a
wingless-type MMTV integration site family, member 8a
chr5_-_30080332 0.89 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr18_-_26715655 0.89 ENSDART00000181497
malt3
MALT paracaspase 3
chr5_+_22067570 0.84 ENSDART00000045574
shisa2a
shisa family member 2a
chr7_+_1449999 0.81 ENSDART00000173864
si:cabz01101003.1
si:cabz01101003.1
chr19_-_46037835 0.74 ENSDART00000163815
nup153
nucleoporin 153
chr11_+_6010177 0.74 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr5_-_30074332 0.72 ENSDART00000147963
bco2a
beta-carotene oxygenase 2a
chr14_-_24111292 0.71 ENSDART00000186611
cpeb4a
cytoplasmic polyadenylation element binding protein 4a
chr6_-_29377092 0.70 ENSDART00000078665
tmem131
transmembrane protein 131
chr18_-_26715156 0.68 ENSDART00000142043
malt3
MALT paracaspase 3
chr3_+_35611625 0.59 ENSDART00000190995
traf7
TNF receptor-associated factor 7
chr8_-_52938439 0.57 ENSDART00000168185
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr10_+_44719697 0.55 ENSDART00000158087
scarb1
scavenger receptor class B, member 1
chr19_+_13994563 0.53 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr19_-_2707048 0.52 ENSDART00000166112
il6
interleukin 6 (interferon, beta 2)
chr22_-_20403194 0.51 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
chr6_-_53326421 0.50 ENSDART00000191740
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr10_-_25543227 0.49 ENSDART00000007778
grik1a
glutamate receptor, ionotropic, kainate 1a
chr2_+_44977889 0.48 ENSDART00000144024
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr6_+_46697710 0.45 ENSDART00000154969
tespa1
thymocyte expressed, positive selection associated 1
chr8_-_13722682 0.44 ENSDART00000142052
si:dkey-258f14.2
si:dkey-258f14.2
chr1_+_7414318 0.42 ENSDART00000127426
si:ch73-383l1.1
si:ch73-383l1.1
chr2_-_7246338 0.42 ENSDART00000186735
zgc:153115
zgc:153115
chr8_+_8947623 0.41 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr24_-_38110779 0.39 ENSDART00000147783
crp
c-reactive protein, pentraxin-related
chr10_+_1849874 0.39 ENSDART00000158897
ENSDART00000149956
apc
adenomatous polyposis coli
chr5_-_35264517 0.36 ENSDART00000114981
ptcd2
pentatricopeptide repeat domain 2
chr24_+_15020402 0.36 ENSDART00000148102
dok6
docking protein 6
chr16_+_7991274 0.36 ENSDART00000179704
ano10a
anoctamin 10a
chr7_-_55454406 0.35 ENSDART00000108646
piezo1
piezo-type mechanosensitive ion channel component 1
chr4_+_9057427 0.34 ENSDART00000113867
slc41a2b
solute carrier family 41 (magnesium transporter), member 2b
chr16_+_9713850 0.33 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr11_-_40504170 0.32 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr22_-_5918670 0.32 ENSDART00000141373
si:rp71-36a1.1
si:rp71-36a1.1
chr12_+_10443785 0.31 ENSDART00000029133
snu13b
SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5)
chr22_+_26703026 0.30 ENSDART00000158756
crebbpa
CREB binding protein a
chr4_+_55758103 0.30 ENSDART00000185964
CT583728.23

chr9_-_50000144 0.29 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha
chr23_+_36308717 0.29 ENSDART00000131711
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr2_+_24781026 0.29 ENSDART00000145692
pde4ca
phosphodiesterase 4C, cAMP-specific a
chr8_+_7740004 0.29 ENSDART00000170184
ENSDART00000187811
fgd1
FYVE, RhoGEF and PH domain containing 1
chr12_+_47448558 0.28 ENSDART00000185689
ENSDART00000105328
fmn2b
formin 2b
chr5_-_69621227 0.27 ENSDART00000178543
aldh2.2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr7_+_19552381 0.27 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr14_-_15154695 0.26 ENSDART00000160677
uvssa
UV-stimulated scaffold protein A
chr6_+_52918537 0.26 ENSDART00000174229
or137-1
odorant receptor, family H, subfamily 137, member 1
chr2_+_7192966 0.25 ENSDART00000142735
si:ch211-13f8.1
si:ch211-13f8.1
chr24_+_42131564 0.25 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr15_+_3125136 0.25 ENSDART00000130968
rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr18_+_3579829 0.25 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr12_-_14211293 0.23 ENSDART00000158399
avl9
AVL9 homolog (S. cerevisiase)
chr23_+_31245395 0.23 ENSDART00000053588
irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr12_-_15002563 0.23 ENSDART00000108852
ENSDART00000141909
pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
chr10_-_40333319 0.23 ENSDART00000150479
taar20a
trace amine associated receptor 20a
chr5_+_27525477 0.22 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr17_-_2721336 0.21 ENSDART00000109582
ENSDART00000192691
ENSDART00000189381
spata7
spermatogenesis associated 7
chr18_-_2727764 0.21 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr10_-_9115383 0.21 ENSDART00000139324
si:dkeyp-41f9.3
si:dkeyp-41f9.3
chr24_-_32582378 0.21 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr9_+_29323163 0.20 ENSDART00000184908
oxgr1b
oxoglutarate (alpha-ketoglutarate) receptor 1b
chr10_+_42678520 0.19 ENSDART00000182496
rhobtb2b
Rho-related BTB domain containing 2b
chr8_+_35356944 0.19 ENSDART00000143243
si:dkeyp-14d3.1
si:dkeyp-14d3.1
chr7_+_29167744 0.18 ENSDART00000076345
slc38a8b
solute carrier family 38, member 8b
chr17_-_4395373 0.18 ENSDART00000015923
klhl10a
kelch-like family member 10a
chr11_-_23322182 0.17 ENSDART00000111289
kiss1
KiSS-1 metastasis-suppressor
chr21_+_7188943 0.16 ENSDART00000172174
agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr7_+_23495986 0.16 ENSDART00000190739
ENSDART00000115299
ENSDART00000101423
ENSDART00000142401
zgc:109889
zgc:109889
chr10_+_39476600 0.16 ENSDART00000135756
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr18_+_32780450 0.15 ENSDART00000168399
olfcg7
olfactory receptor C family, g7
chr5_-_36916790 0.14 ENSDART00000143827
kptn
kaptin (actin binding protein)
chr11_-_19501439 0.13 ENSDART00000158328
ENSDART00000103983
slc2a9l1
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr20_+_35279968 0.13 ENSDART00000168216
ENSDART00000153332
fam49a
family with sequence similarity 49, member A
chr7_-_5711197 0.13 ENSDART00000134367
si:dkey-10h3.2
si:dkey-10h3.2
chr25_+_150570 0.12 ENSDART00000170892
adam10b
ADAM metallopeptidase domain 10b
chr14_-_23799345 0.12 ENSDART00000124144
ENSDART00000181179
ENSDART00000124401
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr21_+_15601100 0.12 ENSDART00000180558
ENSDART00000145454
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr16_-_12470034 0.12 ENSDART00000147483
ephb6
eph receptor B6
chr3_-_36690348 0.12 ENSDART00000192513
myh11b
myosin, heavy chain 11b, smooth muscle
chr4_-_11064073 0.11 ENSDART00000150760
si:dkey-21h14.8
si:dkey-21h14.8
chr7_+_13918349 0.11 ENSDART00000172772
ENSDART00000173384
si:cabz01059983.1
si:cabz01059983.1
chr20_-_7080427 0.11 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
si:ch211-121a2.2
chr4_+_65306260 0.11 ENSDART00000167558
si:dkey-14o6.8
si:dkey-14o6.8
chr8_-_53488832 0.11 ENSDART00000191801
chdh
choline dehydrogenase
chr22_+_12477996 0.10 ENSDART00000177704
CR847870.3

chr21_+_1143141 0.10 ENSDART00000178294
CABZ01086139.1

chr20_-_1560724 0.09 ENSDART00000179193
ENSDART00000092508
ENSDART00000133369
ptprk
protein tyrosine phosphatase, receptor type, K
chr22_-_6219674 0.08 ENSDART00000182582
si:ch211-274k16.2
si:ch211-274k16.2
chr9_-_39968820 0.08 ENSDART00000100311
IKZF2
si:zfos-1425h8.1
chr24_-_11467004 0.08 ENSDART00000144316
pxdc1b
PX domain containing 1b
chr23_-_40817792 0.08 ENSDART00000136343
si:dkeyp-27c8.1
si:dkeyp-27c8.1
chr15_-_18223769 0.08 ENSDART00000139966
or131-1
odorant receptor, family H, subfamily 131, member 1
chr25_-_34284144 0.08 ENSDART00000188109
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr14_+_48960078 0.08 ENSDART00000165514
mif
macrophage migration inhibitory factor
chr7_-_71331690 0.08 ENSDART00000149682
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr4_-_75505048 0.08 ENSDART00000163665
si:dkey-71l4.5
si:dkey-71l4.5
chr22_-_4872418 0.07 ENSDART00000132360
si:ch73-256j6.6
si:ch73-256j6.6
chr23_+_7518294 0.07 ENSDART00000081536
hck
HCK proto-oncogene, Src family tyrosine kinase
chr14_+_45596583 0.07 ENSDART00000110429
zgc:194285
zgc:194285
chr23_+_39331216 0.07 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1
chr3_+_52467879 0.06 ENSDART00000156039
adgre5a
adhesion G protein-coupled receptor E5a
chr22_-_17474583 0.06 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr10_-_24961310 0.05 ENSDART00000037303
si:ch211-214k5.3
si:ch211-214k5.3
chr18_+_46151505 0.05 ENSDART00000015034
ENSDART00000141287
blvrb
biliverdin reductase B
chr20_-_46053720 0.04 ENSDART00000136254
taar12h
trace amine associated receptor 12h
chr10_+_39476432 0.04 ENSDART00000190375
ENSDART00000183954
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr22_+_413349 0.04 ENSDART00000082453
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr16_-_12914288 0.04 ENSDART00000184221
cacng8b
calcium channel, voltage-dependent, gamma subunit 8b
chr2_-_23479714 0.04 ENSDART00000167291
si:ch211-14p21.3
si:ch211-14p21.3
chr6_-_43677125 0.04 ENSDART00000150128
foxp1b
forkhead box P1b
chr5_-_8636168 0.03 ENSDART00000134877
fyba
FYN binding protein a
chr7_-_71331499 0.03 ENSDART00000081245
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr21_-_3201027 0.03 ENSDART00000161256
zbtb7c
zinc finger and BTB domain containing 7C
chr12_-_16990896 0.03 ENSDART00000152402
ifit12
interferon-induced protein with tetratricopeptide repeats 12
chr22_-_18112374 0.03 ENSDART00000191154
ncanb
neurocan b
chr10_+_5645887 0.02 ENSDART00000171426
pdzph1
PDZ and pleckstrin homology domains 1
chr4_-_73572030 0.02 ENSDART00000121652
znf1015
zinc finger protein 1015
chr15_-_28618502 0.01 ENSDART00000086902
slc6a4a
solute carrier family 6 (neurotransmitter transporter), member 4a
chr21_+_41649336 0.00 ENSDART00000164694
ENSDART00000181539
ppp2r2bb
protein phosphatase 2, regulatory subunit B, beta b

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.2 0.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 1.6 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.7 GO:0002931 response to ischemia(GO:0002931)
0.1 0.4 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) Wnt signaling pathway involved in somitogenesis(GO:0090244) negative regulation of canonical Wnt signaling pathway involved in heart development(GO:1905067)
0.1 0.5 GO:0006953 acute-phase response(GO:0006953)
0.1 0.3 GO:0010481 ventriculo bulbo valve development(GO:0003173) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 0.5 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0071387 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0097499 protein localization to nonmotile primary cilium(GO:0097499)
0.0 0.7 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.3 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.2 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0097189 apoptotic body(GO:0097189)
0.1 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0035060 brahma complex(GO:0035060)
0.0 0.7 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK