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PRJNA195909:zebrafish embryo and larva development
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Results for junba+junbb
Z-value: 1.91
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Transcription factors associated with junba+junbb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| junba | dr11_v1_chr1_-_51734524_51734535 | 0.24 | 5.3e-01 | Click! |
| junbb | dr11_v1_chr3_-_7656059_7656059 | 0.15 | 7.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_40992409 Show fit | 1.87 |
ENSDART00000151419
|
transforming growth factor, alpha |
|
| chr25_-_23052707 Show fit | 1.54 |
ENSDART00000024633
|
dual specificity phosphatase 8a |
|
| chr21_-_4695583 Show fit | 1.49 |
ENSDART00000031425
|
zgc:55582 |
|
| chr17_+_25187226 Show fit | 1.47 |
ENSDART00000148431
|
CLN8, transmembrane ER and ERGIC protein |
|
| chr23_+_19590598 Show fit | 1.46 |
ENSDART00000170149
|
sarcolemma associated protein b |
|
| chr6_+_40992883 Show fit | 1.45 |
ENSDART00000076061
|
transforming growth factor, alpha |
|
| chr17_-_12385308 Show fit | 1.40 |
ENSDART00000080927
|
synaptosomal-associated protein, 25b |
|
| chr23_+_19590006 Show fit | 1.39 |
ENSDART00000021231
|
sarcolemma associated protein b |
|
| chr6_+_27667359 Show fit | 1.24 |
ENSDART00000159624
ENSDART00000049177 |
RAB6B, member RAS oncogene family a |
|
| chr10_-_34915886 Show fit | 1.24 |
ENSDART00000141201
ENSDART00000002166 |
cyclin A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of junba+junbb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.6 | GO:2000273 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273) |
| 0.1 | 2.8 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.2 | 2.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 1.8 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.0 | 1.7 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 1.6 | GO:0043065 | positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068) |
| 0.0 | 1.5 | GO:0006998 | nuclear envelope organization(GO:0006998) |
| 0.0 | 1.5 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 0.1 | 1.3 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.2 | 1.2 | GO:0010754 | negative regulation of cGMP-mediated signaling(GO:0010754) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0098794 | postsynapse(GO:0098794) |
| 0.0 | 2.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 2.0 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 1.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 1.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 1.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.3 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.4 | 1.2 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 1.2 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 2.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 2.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 2.2 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.2 | 1.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 1.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 1.4 | GO:0097001 | sphingolipid binding(GO:0046625) ceramide binding(GO:0097001) |
| 0.0 | 1.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 0.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |